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dc.contributor.authorAvcı, Eyüp
dc.contributor.authorKırış, Tuncay
dc.contributor.authorÇelik, Aykan
dc.contributor.authorVarış, Eser
dc.contributor.authorEsin, Fatma Kayaaltı
dc.contributor.authorKöprülü, Diyar
dc.contributor.authorKadı, Hasan
dc.date.accessioned2019-06-10T13:31:45Z
dc.date.available2019-06-10T13:31:45Z
dc.date.issued2018en_US
dc.identifier.issn1471-2261
dc.identifier.urihttps://doi.org/10.1186/s12872-018-0970-6
dc.identifier.urihttps://hdl.handle.net/20.500.12462/5407
dc.descriptionAvcı, Eyüp (Balıkesir Author)en_US
dc.description.abstractBackgroundThe prognostic significance of changes in mean platelet volume (MPV) during hospitalization in ST segment elevation myocardial infarction (STEMI) patients underwent primary percutaneous coronary intervention (pPCI) has not been previously evaluated. The aim of this study was to determine the association of in-hospital changes in MPV and mortality in these patients.MethodsFour hundred eighty consecutive STEMI patients were enrolled in this retrospective study. The patients were grouped as survivors (n=370) or non-survivors (n=110). MPV at admission, and at 48-72h was evaluated. Change in MPV (MPV at 48-72h minus MPV on admission) was defined as MPV.ResultsAt follow-up, long-term mortality was 23%. The non-survivors had a high MPV than survivors (0.37 (-0.1-0.89) vs 0.79 (0.30-1.40) fL, p<0.001). A high MPV was an independent predictor of all cause mortality ((HR: 1.301 [1.070-1.582], p=0.008). Morever, for long-term mortality, the AUC of a multivariable model that included age, LVEF, Killip class, and history of stroke/TIA was 0.781 (95% CI:0.731-0.832, p<0.001). When MPV was added to a multivariable model, the AUC was 0.800 (95% CI: 0.750-0.848, z=2.256, difference p=0.0241, Fig. 1). Also, the addition of MPV to a multivariable model was associated with a significant net reclassification improvement estimated at 24.5% (p=0.027) and an integrated discrimination improvement of 0.014 (p=0.0198).ConclusionsRising MPV during hospitalization in STEMI patients treated with pPCI was associated with long-term mortality.en_US
dc.language.isoengen_US
dc.publisherBMCen_US
dc.relation.isversionof10.1186/s12872-018-0970-6en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectMean Platelet Volumeen_US
dc.subjectST Segment Elevation Myocardial Infarctionen_US
dc.subjectMortalityen_US
dc.titlePrognostic value of rising mean platelet volume during hospitalization in patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary interventionen_US
dc.typearticleen_US
dc.relation.journalBMC Cardiovascular Disordersen_US
dc.contributor.departmentTıp Fakültesien_US
dc.contributor.authorIDhttp://orcid.org/0000-0002-7790-8450en_US
dc.identifier.volume18en_US
dc.identifier.issue226en_US
dc.identifier.startpage1en_US
dc.identifier.endpage8en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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