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dc.contributor.authorBaykan, Hayriye
dc.contributor.authorBaykan, Özgür
dc.contributor.authorEsen, Emre Cem
dc.contributor.authorKara, Hayrettin
dc.contributor.authorHişmioğulları, Adnan Adil
dc.contributor.authorKarlıdere, Tunay
dc.date.accessioned2019-06-21T07:46:02Z
dc.date.available2019-06-21T07:46:02Z
dc.date.issued2018en_US
dc.identifier.issn0101-6083
dc.identifier.issn1806-938X
dc.identifier.urihttps://doi.org/10.1590/0101-60830000000163
dc.identifier.urihttps://hdl.handle.net/20.500.12462/5522
dc.descriptionBaykan, Hayriye (Balikesir Author)en_US
dc.description.abstractBackground: Panic disorder has long been associated with the changes in various neurotransmitters, such as Neuropeptide-S (NPS). Objective: In this study we aimed to determine whether there is a relationship between blood NPS levels and panic disorder. Methods: Twenty nine patients with panic disorder and thirty two healthy control subjects who were age and gender matched were enrolled to the study. Blood samples were taken from participants and plasma NPS levels were quantified by using an ELISA kit. Results: In the study group, median NPS blood level was 16.7 pg/mL and in the control group it was 32.5 pg/mL. There was a statistically significant difference (p = 0.021). Using receiver operating characteristics (ROC) curve, sensitivity and specificity of NPS blood level, for diagnosing panic disorder was calculated, and it was found 79.3% and 56.25% respectively (AUC:0.672, 95% CI: 0.540-0.787). Discussion: Malfunction at the NPS modulatory system in the cortical areas (which is causing excitations in brain areas, such as amygdala and hypothalamus) does not only increase anxiety symptoms and risk of panic disorder but also causes panic disorder patients to have lower plasma NPS levels than the control group. Therefore it can be argued that such malfunction can be treated with a systemic treatment.en_US
dc.description.sponsorshipBalikesir University Scientific Research Projects Coordination Unit 71en_US
dc.language.isoengen_US
dc.publisherUniv Sao Pauloen_US
dc.relation.isversionof10.1590/0101-60830000000163en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectPanic Disorderen_US
dc.subjectNeuropeptide-Sen_US
dc.subjectAnxiety Disorderen_US
dc.titleRelationship between panic disorder and plasma neuropeptide-S levelen_US
dc.typearticleen_US
dc.relation.journalRevista de Psiquiatria Clinicaen_US
dc.contributor.departmentTıp Fakültesien_US
dc.identifier.volume45en_US
dc.identifier.issue4en_US
dc.identifier.startpage79en_US
dc.identifier.endpage81en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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