Advanced Search

Show simple item record

dc.contributor.authorYazıcı, Alper
dc.contributor.authorSarı, Esin
dc.contributor.authorAyhan, Erkan
dc.contributor.authorŞahin, Gözde
dc.contributor.authorTıskaoğlu, Nesime Setge
dc.contributor.authorGürbüzer, Taha
dc.contributor.authorKurt, Hüseyin
dc.contributor.authorErmiş, Sıtkı Samet
dc.date.accessioned2019-08-07T06:20:12Z
dc.date.available2019-08-07T06:20:12Z
dc.date.issued2018en_US
dc.identifier.issn1080-7683
dc.identifier.issn1557-7732
dc.identifier.urihttps://doi.org/10.1089/jop.2017.0064
dc.identifier.urihttps://hdl.handle.net/20.500.12462/5915
dc.descriptionŞahin, Gözde (Balikesir Author)en_US
dc.description.abstractPurpose: To evaluate the effects of acetylsalicylic acid (aspirin) on tear film parameters and dry eye disease. Methods: Fifty-seven patients using low-dose aspirin regularly for antiaggregant purposes as well as 49 controls, who required antiaggregant treatment but who had not yet started, were included in the study. Tear osmolarity, tear break-up time (TBUT), Schirmer and Oxford grading of ocular surface staining were performed on all patients and dry eye symptomatology was assessed using the ocular surface disease index questionnaire (OSDI). Results: The mean osmolarity was 302.11 +/- 16.22 mOsm/L in the aspirin group and 313.88 +/- 19.57 mOsm/L in the control group (P < 0.01). The mean Schirmer's score was 24.16 +/- 10.52 mm and 21.94 +/- 10.11 mm (P = 0.232), TBUT was 13.61 +/- 3.31 s and 10.39 +/- 4.46 s (P < 0.01), OSDI score was 5.15 +/- 5.98 and 16.94 +/- 14.17 (P < 0.01), and Oxford score was 0.12 +/- 0.33 and 0.12 +/- 0.44 in aspirin and control groups, respectively (P = 0.99). Dry eye diagnosis was lower in the aspirin group, but statistical significance was present only in TBUT and osmolarity-based dry eye diagnosis (P <= 0.01). In terms of symptom-based dry eye diagnosis with the threshold of OSDI >= 23, none of the aspirin group had dry eye diagnosis, whereas 32.6% of the control group had the diagnosis (P < 0.01). Conclusions: The use of low-dose aspirin might be great option for treatment of ocular surface inflammatory disease through increasing TBUT and decreasing tear osmolarity with a resultant symptomatic satisfaction.en_US
dc.language.isoengen_US
dc.publisherMary Ann Lieberten_US
dc.relation.isversionof10.1089/jop.2017.0064en_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectAspirinen_US
dc.subjectTear Osmolarityen_US
dc.subjectTBUTen_US
dc.subjectSchirmeren_US
dc.subjectOSDIen_US
dc.titleThe effect of low-dose aspirin on dry eye parameters and ocular surface disease index questionnaireen_US
dc.typearticleen_US
dc.relation.journalJournal of Ocular Pharmacology and Therapeuticsen_US
dc.contributor.departmentTıp Fakültesien_US
dc.identifier.volume34en_US
dc.identifier.issue3en_US
dc.identifier.startpage256en_US
dc.identifier.endpage259en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record