Age supplementation modulates il-6, il-10 and hsp27 response in healthy men: effect on the muscle strength
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Aged garlic extract (AGE) is a dietary supplement and is reported have numerous health benefits including protection against oxidative stress, inflammatory, and dyslipidemia. The purpose of this investigation was to test the effects of AGE on the serum levels of interleukin-6 (IL-6), interleukin-10 (IL-10), heat shock protein 27 (HSP27), testosterone, cortisol, total antioxidant status (TAS), total oxidant status (TOS) as well as exercise performance parameters. Sedentary healthy men (n-6) participated in this study. After baseline cycling performance and isokinetic muscle contraction testing, the subjects ingested AGE (5 ml) for 10 days. At the end of this period, venous blood samples were obtained in the morning prior to and 10 days after AGE supplementation, followed by another sample 10 days after the supplementation (wash out) period. The serum was analysed for IL-6, IL-10, HSP27, cortisol, testosterone, total antioxidant status (TAS), and total oxidant status (TOS). The serum samples were analysed and physical performance evaluated at the beginning of the study, end of AGE supplementation and at the end of the washout period. Cycling performance parameters were not affected by AGE supplementation, whereas isokinetic muscle strength properties improved in the post-supplementation period. AGE upregulated serum level of the IL-6, IL-10 and HSP27 response in the post-supplementation period. However, serum level of the cortisol, testosterone, total antioxidant status (TAS), total oxidant status (TOS) were not affected by AGE supplementation. Therefore, AGE supplementation enhanced isokinetic knee muscle work parameters and it may play a protective role against the oxidative stress and apoptosis by up regulating the levels of HSP27, IL-10 and IL-6.