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dc.contributor.authorKurt, Belma Zengin
dc.contributor.authorSönmez, Fatih
dc.contributor.authorGökçe, Başak
dc.contributor.authorErgün, Adem
dc.contributor.authorGencer, Nahit
dc.contributor.authorDemir, Taki
dc.contributor.authorArslan, Oktay
dc.contributor.authorKüçükislamoğlu, Mustafa
dc.date.accessioned2019-10-10T12:09:40Z
dc.date.available2019-10-10T12:09:40Z
dc.date.issued2016en_US
dc.identifier.issn1068-1620
dc.identifier.issn1608-330X
dc.identifier.urihttps://doi.org/10.1134/S1068162016050046
dc.identifier.urihttps://hdl.handle.net/20.500.12462/6786
dc.descriptionErgun, Adem (Balikesir Author)en_US
dc.description.abstractCoumarin and heterocyclic compounds incorporating urea have clinical applications as antiepileptics, diuretics, and antiglaucoma agents due to their carbonic anhydrase inhibitory properties. We investigated inhibition of carbonic anhydrase I and II with a series of coumarylthiazole derivatives containing urea/thiourea groups. All the investigated compounds exhibited inhibitory activity on both hCA I and hCA II, with 1-(3-chlorophenyl)-3-(4-(2-oxo-2H-chromen-3-yl)thiazol-2-yl)urea being the strongest inhibitor. Structure-activity relationship study showed that most of urea derivatives were more inhibiting for hCA I and hCA II than thiourea derivatives. The electron-withdrawing groups at the phenyl ring increased the inhibitory activity compared to electron-donating groups.en_US
dc.description.sponsorshipSakarya University - 2012-02-04-035en_US
dc.language.isoengen_US
dc.publisherMaik Naukaen_US
dc.relation.isversionof10.1134/S1068162016050046en_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectCarbonic Anhydraseen_US
dc.subjectCoumarinen_US
dc.subjectInhibitoren_US
dc.subjectStructure-Activity Relationshipen_US
dc.titleIn vitro inhibition effects on erythrocyte carbonic anhydrase I and II and structure-activity relationships of cumarylthiazole derivativesen_US
dc.typearticleen_US
dc.relation.journalRussian Journal of Bioorganic Chemistryen_US
dc.contributor.departmentFen Edebiyat Fakültesien_US
dc.contributor.authorID0000-0002-3266-4579en_US
dc.contributor.authorID0000-0001-7092-8857en_US
dc.identifier.volume42en_US
dc.identifier.issue5en_US
dc.identifier.startpage506en_US
dc.identifier.endpage511en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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