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dc.contributor.authorAksöz, Elif
dc.contributor.authorGöçmez, Semil Sevcen
dc.contributor.authorDemirtaş, Tuğçe
dc.contributor.authorUtkan, Tijen
dc.date.accessioned2019-10-17T07:14:39Z
dc.date.available2019-10-17T07:14:39Z
dc.date.issued2015en_US
dc.identifier.issn0924-977X
dc.identifier.issn1873-7862
dc.identifier.urihttps://doi.org/10.1016/S0924-977X(15)30442-9
dc.identifier.urihttps://hdl.handle.net/20.500.12462/7560
dc.descriptionAksöz, Elif (Balikesir Author)en_US
dc.description.abstractPurpose:Epidemiological, clinical and experimental data supporta link between type 2 diabetes mellitus and Alzheimer’s disease(AD). AD is a progressive neurodegenerative disorder of the brainthat is characterized by impairment of memory and cognitivefunction due to cholinergic nervous system dysfunction. Met-formin, the most commonly used drug for the treatment of type IIdiabetes, has been shown to induce hippocampal neurogenesis andto enhance spatial learning [1]. Scopolamine, a non-selective mus-carinic receptor antagonist, blocks cholinergic neurotransmissionand impairs behavioral function, including learning and memory.Therefore, scopolamine administration to animals is used as anexperimental model of the cognitive deterioration and memorydisturbances in AD. The aim of this study was to investigate theeffect of metformin on spatial learning and memory behavior inscopolamine-induced memory impairment in naive rats.en_US
dc.language.isoengen_US
dc.publisherElsevier Science BVen_US
dc.relation.isversionof10.1016/S0924-977X(15)30442-9en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleProtective effects of metformin in scopolamine-induced cognitive impairment in ratsen_US
dc.typeotheren_US
dc.relation.journalEuropean Neuropsychopharmacologyen_US
dc.contributor.departmentTıp Fakültesien_US
dc.contributor.authorID0000-0002-4827-804Xen_US
dc.identifier.volume25en_US
dc.identifier.startpage350en_US
dc.identifier.endpage351en_US
dc.relation.publicationcategoryDiğeren_US


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