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dc.contributor.authorHopa, Ersin
dc.contributor.authorBaşaran, İsmet
dc.contributor.authorSinan, Selma
dc.contributor.authorTuran, Yusuf
dc.contributor.authorÇakır, Ümit
dc.date.accessioned2019-10-17T07:15:14Z
dc.date.available2019-10-17T07:15:14Z
dc.date.issued2014en_US
dc.identifier.issn1475-6366
dc.identifier.issn1475-6374
dc.identifier.urihttps://doi.org/10.3109/14756366.2013.845819
dc.identifier.urihttps://hdl.handle.net/20.500.12462/7563
dc.descriptionÇakır, Ümit (Balıkesir author)en_US
dc.description.abstractInhibitory effects of some synthesized dihydroxycoumarin compounds on purified G6PD were investigated. For this purpose, initially human erythrocyte G6PD was purified 7069-fold in a yield of 33.6% by using ammonium sulfate precipitation and affinity chromatography which includes 2',5'-ADP Sepharose 4B. The purified enzyme showed a single band on sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). Enzyme activity was determined spectrophotometrically according to Beutler method at 340 nm. 6,7-Dihydroxy-3-(2-methylphenyl)-2H-chromen-2-one (OPC), 6,7-dihydroxy-3-(3-methylphenyl)-2H-chromen-2-one (MPC) and 6,7-dihydroxy-3-(4-methylphenyl)-2H-chromen-2-one (PPC) were used as dihydroxycoumarin compounds. This study has demonstrated that G6PD activity is very highly sensitive to study coumarin derivatives.en_US
dc.description.sponsorshipScientific Research Council of Balikesir Universityen_US
dc.language.isoengen_US
dc.publisherTaylor & Francıs Ltden_US
dc.relation.isversionof10.3109/14756366.2013.845819en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCoumarin Derivativesen_US
dc.subjectGlucose-6-Phosphate Dehydrogenaseen_US
dc.subjectİn Vitro İnhibitionen_US
dc.titleIn vitro inhibition effects of some coumarin derivatives on human erythrocytes glucose-6-phosphate dehydrogenase activitiesen_US
dc.typearticleen_US
dc.relation.journalJournal of Enzyme Inhibition and Medicinal Chemistryen_US
dc.contributor.departmentFen Edebiyat Fakültesien_US
dc.contributor.authorID0000-0001-7641-8938en_US
dc.identifier.volume29en_US
dc.identifier.issue5en_US
dc.identifier.startpage728en_US
dc.identifier.endpage732en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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