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dc.contributor.authorHişmioğulları, Şahver Ege
dc.contributor.authorSunay, Fatma Bahar
dc.contributor.authorPaksoy, Serpil
dc.contributor.authorAkşit, Hasan
dc.date.accessioned2019-10-17T07:44:28Z
dc.date.available2019-10-17T07:44:28Z
dc.date.issued2014en_US
dc.identifier.issn0035-1555
dc.identifier.issn2258-0646
dc.identifier.urihttps://hdl.handle.net/20.500.12462/7691
dc.descriptionHişmioğulları, Şahver Ege (Balıkesir Author)en_US
dc.description.abstractCurcumin, a polyphenolic compound of turmeric has been reported to reduce non-alcoholic steatohepatitis (NASH) and oxidative stress in rats. The aim of the present study was to examine the protective effect of curcumin (CUR) on carbon tetrachloride (CCl4) - induced NASH and to evaluate the detailed mechanisms by which CUR exerts its protective action. Thirty male Wistar-Albino rats weighing 250-300 g were randomly divided into three groups: Administrations of oral olive oil (control), CCl4 (0.5 mg/kg in olive oil s.c.) every other day for 3 weeks, and CCl4 (0.5 mg/kg in olive oil s.c. every other day) plus CUR (200 mg/kg/d, orally in olive oil) every day for 3 weeks. The administration of CCl4 resulted in steatohepatitis and increased malondialdehyde (MDA) content of the liver. The administration of CUR decreased lipid deposition during histopathological examination and decreased MDA accumulation. These findings indicate that CUR may have a protective role during liver injury occurring with oxidative damages.en_US
dc.language.isoengen_US
dc.publisherEcole Nationale Veterinaire Toulouseen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLiver Fibrosisen_US
dc.subjectSteatohepatitisen_US
dc.subjectCurcuminen_US
dc.subjectCarbon Tetrachlorideen_US
dc.subjectAntioxidanten_US
dc.subjectHepatoprotectionen_US
dc.titleThe protective effect of curcumin on carbon tetrachloride induced liver damageen_US
dc.typearticleen_US
dc.relation.journalRevue De Medecine Veterinaireen_US
dc.contributor.departmentVeteriner Fakültesien_US
dc.identifier.volume165en_US
dc.identifier.issue7-8en_US
dc.identifier.startpage194en_US
dc.identifier.endpage200en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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