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dc.contributor.authorKaravelioğlu, Ergün
dc.contributor.authorGonül, Yücel
dc.contributor.authorKokulu, Serdar
dc.contributor.authorHazman, Ömer
dc.contributor.authorBozkurt, Fatih
dc.contributor.authorKoçak, Ahmet
dc.contributor.authorEser, Olcay
dc.date.accessioned2019-10-17T10:31:47Z
dc.date.available2019-10-17T10:31:47Z
dc.date.issued2014en_US
dc.identifier.issn0360-3997
dc.identifier.issn1573-2576
dc.identifier.urihttps://doi.org/10.1007/s10753-014-9811-7
dc.identifier.urihttps://hdl.handle.net/20.500.12462/8124
dc.descriptionEser, Oktay (Balıkesir Author)en_US
dc.description.abstractWe investigated the anti-inflammatory and antiapoptotic effects of interleukin-18 binding protein (IL-18BP) on spinal cord ischemia/reperfusion (I/R) injury in rats. Twenty-one adult male rats were divided into three groups: sham, I/R, and I/R+IL-18BP. Proinflammatory cytokines were determined in rat blood samples by using ELISA, while apoptosis was immunohistochemically evaluated in spinal cord tissue using caspase 3. Both IL-18 and TNF-alpha were significantly decreased in the IL-18BP group compared to that in the sham group. The highest caspase 3 levels were observed in the I/R group, while the lowest levels were found in the sham group. The mean Tarlov score of the I/R group was significantly lower than that of the sham group. However, the mean Tarlov score of the IL-18BP group was significantly higher than that of the I/R group. The results of the current study demonstrate that IL-18BP plays both anti-inflammatory and antiapoptotic roles in spinal cord I/R injury.en_US
dc.language.isoengen_US
dc.publisherSprİngeren_US
dc.relation.isversionof10.1007/s10753-014-9811-7en_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectInterleukin-18 Binding Proteinen_US
dc.subjectSpinal Corden_US
dc.subjectİschemia-Reperfusionen_US
dc.subjectCytokinesen_US
dc.subjectCaspase 3en_US
dc.titleAnti-inflammatory and antiapoptotic effect of interleukine-18 binding protein on the spinal cord ischemia-reperfusion injuryen_US
dc.typearticleen_US
dc.relation.journalInflammatİonen_US
dc.contributor.departmentTıp Fakültesien_US
dc.contributor.authorID0000-0002-1669-0988en_US
dc.contributor.authorID0000-0002-6611-1032en_US
dc.contributor.authorID0000-0002-2702-6847en_US
dc.identifier.volume37en_US
dc.identifier.issue3en_US
dc.identifier.startpage917en_US
dc.identifier.endpage923en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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