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dc.contributor.authorKara, Adem
dc.contributor.authorÜnal, Deniz
dc.contributor.authorŞimşek, Nejdet
dc.contributor.authorYücel, Atakan
dc.contributor.authorYücel, Nermin
dc.contributor.authorSelli, Jale
dc.date.accessioned2019-10-17T10:58:15Z
dc.date.available2019-10-17T10:58:15Z
dc.date.issued2014en_US
dc.identifier.issn0951-3590
dc.identifier.issn1473-0766
dc.identifier.urihttps://doi.org/ 10.3109/09513590.2013.864270
dc.identifier.urihttps://hdl.handle.net/20.500.12462/8346
dc.descriptionŞimşek, Nejdet (Balıkesir Author)en_US
dc.description.abstractDiabetes mellitus (DM) is one of the most common and chronic diseases, especially in postmenopausal periods. Neuro-degeneration occurs more frequently in post-menopausal diabetics. Therefore, we investigated ovariectomized rats cerebellar cortex response to the estradiol deficiency and hyperglycemia. For the ovariectomy, the rats were bilaterally ovariectomized, and then DM induced by a single dose of Alloxan monohydrate injection in ovariectomy or/and diabetic groups. During light and electron microscopic examination, degenerated Purkinje cells membrane, swollen organelles, degenerated mitochondria, edema formation and vacuolization were seen in the ovariectomy and ovariectomy-diabetic groups sections. In addition, increased apoptotic activity was observed in the ovariectomy and ovariectomy-diabetic groups compared to the control group. We demonstrated that estradiol and insulin deficiency can affect the cerebellar cortex, which support the hypothesis that the execution of neuronal damages in post-menopausal diabetics. Also, diabetes and menopause are major risks factors for many disorders including nervous system and the number of postmenopausal-diabetics are increasing world-wide.en_US
dc.language.isoengen_US
dc.publisherInforma Healthcareen_US
dc.relation.isversionof10.3109/09513590.2013.864270en_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectApoptosisen_US
dc.subjectCerebellumen_US
dc.subjectDiabetes Mellitusen_US
dc.subjectMenopauseen_US
dc.subjectOvariectomyen_US
dc.titleUltra-structural changes and apoptotic activity in cerebellum of post-menopausal-diabetic rats: a histochemical and ultra-structural studyen_US
dc.typearticleen_US
dc.relation.journalGynecological Endocrinologyen_US
dc.contributor.departmentTıp Fakültesien_US
dc.identifier.volume30en_US
dc.identifier.issue3en_US
dc.identifier.startpage226en_US
dc.identifier.endpage231en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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