Advanced Search

Show simple item record

dc.contributor.authorBytyqi-Damoni, Arlinda
dc.contributor.authorGenç, Hayriye
dc.contributor.authorBytyqi-Damoni, Arlinda
dc.contributor.authorZengin, Mustafa
dc.contributor.authorBeyaztaş, Serap
dc.contributor.authorGençer, Nahit
dc.contributor.authorArslan, Oktay
dc.date.accessioned2019-10-17T11:42:53Z
dc.date.available2019-10-17T11:42:53Z
dc.date.issued2012en_US
dc.identifier.issn1073-1199
dc.identifier.issn1532-4184
dc.identifier.urihttps://doi.org/10.3109/10731199.2012.678943
dc.identifier.urihttps://hdl.handle.net/20.500.12462/8707
dc.descriptionGençer, Nahit (Balikesir Author)en_US
dc.description.abstractCarbazole substituted imines (2a-I) were prepared from N-methyl-3-amino carbazole with different aldehydes. The imines compounds undergo (2 + 2) cycloaddition reactions with in situ ketenes to produce beta-lactam compounds (3a-I). The beta-lactam compounds were tested as inhibitors of the xanthine oxidase (XO) purified from bovine milk. The results show that these compounds exhibit inhibitory effects on XO at low concentrations with IC50 values ranging from 21.65 to 58.04 mu M. The most effective compound for XO was 4-(4-chlorophenyl)-1-(9-ethyl-9H-carbazol-3-yl)-3-phenylazetidin-2-one with IC50 of 21.65 mu M. The lactams investigated here showed effective XO inhibitory effects, in the same range as the clinically used allopurinol.en_US
dc.description.sponsorshipSakarya BAP-2010 - 02-04 - 012en_US
dc.language.isoengen_US
dc.publisherInforma Healthcareen_US
dc.relation.isversionof10.3109/10731199.2012.678943en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectXanthine Oxidaseen_US
dc.subjectInhibitionen_US
dc.subjectPurificationen_US
dc.subjectBeta-Lactam Compoundsen_US
dc.titleIn vitro effect of novel beta-lactam compounds on xanthine oxidase enzyme activityen_US
dc.typearticleen_US
dc.relation.journalArtificial Cells Blood Substitutes and Biotechnologyen_US
dc.contributor.departmentFen Edebiyat Fakültesien_US
dc.contributor.authorID0000-0001-7092-8857en_US
dc.identifier.volume40en_US
dc.identifier.issue6en_US
dc.identifier.startpage369en_US
dc.identifier.endpage377en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record