Browsing by Author "Özensoy, Özen"
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Carbonic anhydrase from Cyprinus carpio
Özensoy, Özen; Arslan, Oktay; Işık, Semra (Elsevier GMBH, 2003)Carbonic anhydrase (CA) is the basic enzyme in the breathing function and catalyses the reversible hydration of CO2 to HCO3- and H+.A method is introduced to purify the carbonic anhydrase from erythrocytes of the carp ... -
Carbonic anhydrase inhibitors. Inhibition of red blood cell ostrich (Struthio camelus) carbonic anhydrase with a series of aromatic and heterocyclic sulfonamides
Özensoy, Özen; Arslan, Oktay; Işık, Semra; Arslan, Mikail; Scozzafava, Andrea; Supuran, Claudiu T. (Taylor & Francis Ltd, 2005)The purification of red blood cell carbonic anhydrase (CA, EC 4.2. 1. 1) from ostrich (scCA) blood is reported, as well as an inhibition study of this enzyme with a series of aromatic and heterocylic sulfonamides. The ... -
Carbonic anhydrase inhibitors: Inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides
Özensoy, Özen; Puccetti, Luca; Fasolis, Giuseppe; Arslan, Oktay; Scozzafava, Andrea; Supuran, Claudiu T. (Pergamon-Elsevier Science Ltd, 2005)The inhibition of the two transmembrane, tumor-associated isozymes of carbonic anhydrase (CA, EC 4.2.1.1) of human origin, hCA IX and XII, with a library of aromatic and heteroaromatic sulfonamides has been investigated. ... -
Carbonic anhydrase inhibitors: purification and inhibition studies of pigeon (Columba livia var. domestica) red blood cell carbonic anhydrase with sulfonamides
Özensoy, Özen; Arslan, Mikail; Supuran, Claudiu T. (Informa Healthcare, 2011)A carbonic anhydrase (CA, EC 4.2.1.1) from red blood cells of pigeons (Columba livia var. domestica), clCA, was purified to homogeneity. Its kinetic parameters for the CO(2) hydration reaction were measured. With a k(cat)/K(m) ... -
Carbonic anhydrase IX as prognostic marker for tumor progression and as a target for novel antitumor drugs
Özensoy, Özen; Supuran, Claudiu T. (2007)Metaloenzim karbonik anhidrazın [CA, EC 4.2.1.1] izoenzimi IX -CA IX- hipokside yüksek düzeyde ifade edilen genlerden birisidir. CA IX özellikle hipoksik tümör dokularında bulunup gastrointestinal yoldaki düşük düzeydeki ... -
Carbonic anhydrase IX as prognostic marker for tumor progression and as a target for novel antitumor drugs
Özensoy, Özen; Supuran, Claudiu T. (Turkish Biochem Soc, 2007)One of the genes highly upregulated by hypoxia is that encoding isozyme IX of the metalloenzyme carbonic anhydrase [ CA, EC 4.2.1.1], CA IX. CA IX is a high activity tumor- associated membrane enzyme predominantly found ... -
Corrigendum to "An evaluation of cytosolic erythrocyte carbonic anhydrase and catalase in carcinoma patients: An elevation of carbonic anhydrase activity" [Clin. Biochem. 39 (2006) 804-809] (DOI:10.1016/j.clinbiochem.2006.03.001)
Özensoy, Özen; Köçkar, Feray Tura; Arslan, Oktay; Işık, Semra; Supuran, Claudiu T.; Lyon, Malcolm (2007)ÖZET YOK -
Corrigendum to “An evaluation of cytosolic erythrocytecarbonic anhydrase and catalase in carcinoma patients:An elevation of carbonic anhydrase activity” [Clin. Biochem. 39 (2006) 804–809]
Özensoy, Özen; Köçkar, Feray; Arslan, Oktay; Işık, Semra; Supuran, Claudlu T.; Lyon, Malcolm (Pergamon-Elsevier Science Ltd, 2007)No Abstract -
Differential in vitro effects of some pesticides on carbonic anhydrase activities from some freshwater and seawater fish erythrocytes
Işık, Şahin; Köçkar, Feray; Özensoy, Özen; Arslan, Oktay (Parlar Scientific Publications (P S P), 2004)The purpose of this study was to investigate the in vitro effects of 4 commonly used pesticides: the fungicides Nuarimol(TM) [alpha-(2-chlorophenyl)-alpha-(4-fluorophenyl)-5-pyridinemethanol] and Fenarimol(TM) [alpha-(2- ... -
Differential in vitro inhibition effects of some antibiotics on tumor associated carbonic anhydrase isozymes of hCA-IX and hCA-XII
Özensoy, Özen; Arslan, Oktay; Köçkar, Feray (Informa Healthcare, 2008)Hypoxia is a common characteristic of locally advanced solid tumors that has been associated with diminished therapeutic response and malignant progression. Human carbonic anhydrase (hCA) hCA IX and XII isozymes are tumor ... -
Eritrositlerden karbonik anhidraz izoenzimlerinin saflaştırılması için yeni bir afinite jelinin sentezi ve uygulanması
Özensoy, Özen (Balıkesir Üniversitesi Fen Bilimleri Enstitüsü, 2002)Karbonik anhidraz (E.C 4.2.1.1), CO2 hidratasyon ve HCO3* dehidratasyon reaksiyonlarım katalizleyen, çinko İyonu içeren bir metaloenzimdir. Bu çalışmada, karbonik anhidraz (CA) izoenzimlerinin saflaştırılması için yeni bir ... -
An evaluation of cytosolic erythrocyte carbonic anhydrase and catalase in carcinoma patients: An elevation of carbonic anhydrase activity
Özensoy, Özen; Köçkar, Feray; Arslan, Oktay; Işık, Semra; Supuran, Claudiu T.; Lyon, Malcolm (Pergamon-Elsevier Science Ltd, 2006)Objectives: The antioxidant enzyme catalase and the CO2/HCO3- exchange enzyme carbonic anhydrase are both present in significant amounts in the cytosol of erythrocytes. The aim of the present study was to investigate whether ... -
In vitro inhibition effects of some new sulfonamide inhibitors on human carbonic anhydrase I and II
Çakır, Ümit; Uğraş, Halil İbrahim; Özensoy, Özen; Sinan, Selma; Arslan, Oktay (Taylor & Francis Ltd, 2004)A new series of aromatic and heterocyclic sulfonamides, including six new derivatives, 2-(3-cyclohexene-1-carbamido)-1,3,4-thiadiazole-5-sulfonamide (CCTS), 4-(3-cyclohexene-1-carbamido) methyl-benzenesulfonamide (CCBS), ... -
In vitro inhibition of cytosolic carbonic anhydrases I and II by some new dihydroxycoumarin compounds
Başaran, İsmet; Sinan, Selma; Çakır, Ümit; Bulut, Mustafa; Arslan, Oktay; Özensoy, Özen (Taylor & Francis Ltd, 2008)A new series of 6, 7-dihydroxy-3-(methylphenyl) chromenones, including three new derivatives, i.e. 6,7-dihydroxy-3-(2-methylphenyl)-2H-chromen-2-one (OPC); 6,7-dihydroxy-3-(3-methylphenyl)-2H-chromen-2-one (MPC); ... -
In vitro investigation of some plant growth regulators on antioxidant enzyme activities
Beyaztaş, Serap; Gençer, Nahit; Özensoy, Özen; Arslan, Oktay (Blackwell Publishing, 2006)yok -
Kanser ilişkili karbonik anhidraz IX ve XII izoenzimlerinin (CA-IX,CA-XII)ekspresyonu, saflaştırılması ve bazı bileşiklere karşı inhibisyon etkilerinin araştırılması
Özensoy, Özen (Balıkesir Üniversitesi Fen Bilimleri Enstitüsü, 2006)Çinko içeren karbonik anhidraz ailesi (CA, EC 4.2.1.1) karbondioksit ve bikarbonat iyonu arasındaki basit geri dönüşümlü fizyolojik reaksiyonu katalizler. Solunum, doku ve akciğerlerdeki CO2 / bikarbonat transportu, pH ve ... -
Mutation of active site residues Asn67 to Ile, Gln92 to Val and Leu204 to Ser in human carbonic anhydrase ii: influences on the catalytic activity and affinity for inhibitors
Türkoğlu, Sümeyye; Maresca, Alfonso; Alper, Meltem; Köçkar, Feray; Işık, Semra; Sinan, Selma; Özensoy, Özen; Arslan, Oktay (Pergamon-Elsevier Science Ltd, 2012)Site-directed mutagenesis has been used to change three amino acid residues involved in the binding of inhibitors (Asn67Ile; Gln92Val and Leu204Ser) within the active site of human carbonic anhydrase (CA, EC 4.2.1.1) II ... -
A new method for purification of carbonic anhydrase isozymes by affinity chromatography
Özensoy, Özen; Arslan, Oktay; Sinan, Selma Öznür (Maik Nauka/Interperiodica/Springer, 2004)A new affinity gel for purification of carbonic anhydrase isozymes was prepared using EUPERGIT(R) C-250L derivatized with p-aminobenzenesulfonamide, an inhibitor of carbonic anhydrase. The binding capacity of the affinity ... -
Purification of carbonic anhydrase from dog erythrocytes and investigation of in vitro inhibition by various compounds
Bayram, Turan; Arslan, Oktay; Uğras, Halil İbrahim; Çakır, Ümit; Özensoy, Özen (Taylor & Francis Ltd, 2007)The enzyme carbonic anhydrase ( E. C. 4.2.1.1) has a stimulatory effect on glaucoma, an eye disease that has a risk to dogs, which are models for the human eye disease, that is similar to that in humans. In this study, ... -
Purification of mulberry (Morus alba L.) polyphenol oxidase by affinity chromatography and investigation of its kinetic and electrophoretic properties
Arslan, Oktay; Erzengin, Mahmut; Sinan, Selma; Özensoy, Özen (Elsevier Science Bv, 2004)Polyphenol oxidase (PPO) was isolated from mulberry (Morus alba L.) fruit using a Sepharose 4B-L-tyrosine-p-amino benzoic acid affinity column. The purified enzyme was migrated as a single band on native and SDS-poliacrylamide ...
