Browsing by Author "Şimşek, Nejdet"
Now showing items 1-13 of 13
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Ameliorative effect of selenium in cisplatin-induced testicular damage in rats
Şimşek, Nejdet; Koç, Akif; Karadeniz, Ali; Yıldırım, Mehmet Erol; Çelik, Hüseyin Tuğrul; Sarı, Erhan; Kara, Adem (Elsevier GMBH, 2016)In this study, we investigated the protective effect of selenium (Se) on cisplatin (Cis) induced testicular damage using histopathological, immunohistochemical and biochemical approaches. Twenty-one male Wistar rats were ... -
Cabazitaxel causes a dose-dependent central nervous system toxicity in rats
Karavelioglu, Ergün; Gönül, Yücel; Akşit, Hasan; Boyacı, Mehmet Gazi; Karademir, Mustafa; Şimşek, Nejdet; Güven, Mustafa; Dündar, Ekrem (Elsevier, 2016)Background: Chemotherapeutic agents may lead to serious neurological side effects, which in turn can deteriorate the quality of life and cause dose limiting. Direct toxic effect or metabolic derangement of chemotherapeutic ... -
Distribution and location of endocrine cells in the pancreas of the sparrowhawk, accipiter nisus
Bu çalışmada, atmaca pankreasının dorsal, ventral ve splenik loblarında bulunan endokrin hücrelerin dağılımı immun- histokimysal metotlarla belirlenmiştir. Pankreas dokusu anti-glukagon, anti-insulin, anti-gastrin ve ... -
Distribution and location of endocrine cells in the pancreas of the sparrowhawk, accipiter nisus
Kara, Adem; Tekiner, Deniz; Şimşek, Nejdet; Balkaya, Hülya; Özüdoğru, Zekeriya (Kafkas Üniv, 2014)The distribution and location of endocrine cells were determined in the dorsal, ventral, and splenic lobes of sparrowhawk pancreas using immunohistochemical methods. In this study, pancreatic tissues were stained with ... -
Enzyme histochemical, histometric and hematological features of peripheral blood cells in sparrowhawk accipiter nisus (Falconiformes: Accipitridae)
Şengül, Emin; Gelen, Volkan; Kara, Adem; Şimşek, Nejdet; Karadeniz, Abdülkadir; Balkaya, Hülya (Taylor & Francis Ltd, 2015)The aim of this study was to determine the enzyme-histochemical, histometric and hematological features of peripheral blood cells in the Sparrowhawk (Accipiter nisus). Therefore, blood samples obtained from the wings ... -
Immunohistochemical distribution of glucagon -, insulin -, somatostatin -, gastrin-, and serotonin-containing cells in the pancreas of the Van cat
Karaca, Turan; Kara, Adem; Şimşek, Nejdet; Uslu, Sema; Tekiner, Deniz; Yörük, Mecit (Scientific Technical Research Council Turkey-Tubitak, 2014)The regional distribution, relative frequency, and appearance of glucagon (A-cell)-, insulin (B-cell)-, somatostatin (D-cell)-, gastrin (G-cell)-, and serotonin (EC-cell)-secreting cells in the endocrine and exocrine ... -
Increased expression of matrix metalloproteinases in ligamentum flavum hypertrophy of the patients with lumbar spinal stenosis
Eser, Betül; Eser, Olcay; Şimşek, Nejdet; Bülbül, Erdoğan; Güven, Mustafa (Kamla-Raj Enterprises, 2016)This paper shows an investigation of the expressions of MMP-3,-13 and their polymorphisms in patients with lumbar spinal stenosis (LSS). Hypertrophied LF tissues and peripheral bloods were obtained from 50 patients with ... -
İnorganik ve organik bakır, çinko ve mangan eklenen diyetlerle beslenen yumurta tavuklarının ince bağırsak morfolojisi üzerine histokimyasal ve histometrik bir çalışma
Araştırmada, yumurta tavuğu rasyonlarında NRC (National Research Council) (1994) tarafından yumurta tavukları için önerilen düzeyde ve bu düzeyin %66'sı ile %33'ü oranlarında inorganik ve organik bakır (Cu), çinko (Zn) ve ... -
The melatonin attenuates alloxan ınduced post-diabetic testicular damage and oxidative effects in rats
Akman, Orhan; Şengül, Emin; Özkanlar, Seçkin; Can, Serpil; Koç, Akif; Karadeniz, Ali; Şimşek, Nejdet (Kafkas Univ, 2015)The aim of this study was to examine the protective effect of melatonin (MLT) on the alloxan-induced post-diabetic testicular damage in rats. Forty-eight Sprague Dawley male rats were divided into four groups (n = 12). ... -
Melatonin modulates the immune system response and inflammation in diabetic rats experimentally-induced by alloxan
Özkanlar, Seçkin; Kara, Adem; Şengül, Emin; Şimşek, Nejdet; Karademir,Ali; Kurt,N. (Georg Thıeme Verlag KG, 2016)Diabetes mellitus (DM) is a metabolic disease, which causes an increase in the proinflammatory cytokines tumor necrosis factor- (TNF-) and interleukin 1 (IL-1), and also proliferation of monocyte chemotactic protein. In ... -
The neuroprotective effects of 2-apb in rats with experimentally-induced severe acute pancreatitis
Karademir, Mustafa; Gönül, Yücel; Şimşek, Nejdet; Eser, Olcay (Comenius Univ, 2018)AIM: The objective of this study was to determine the neuroprotective effects of 2-aminoethyl diphenyl-borinate (2-APB) on the brains of rats with experimentally-induced severe acute pancreatitis. MATERIALS AND METHODS: ... -
Selenium protects cerebral cells by cisplatin induced neurotoxicity
Karavelioğlu, Ergün; Boyacı, Mehmet Gazi; Şimşek, Nejdet; Sönmez, Mehmet Akif; Koç, Rabia; Karademir, Mustafa; Güven, Mustafa; Eser, Olcay (Acta Cirurgica Brasileira, 2015)PURPOSE: To evaluate the central nervous system toxicity of cisplatin and neuroprotective effect of selenium. METHODS: Twenty-one male Wistar albino rats were divided into three groups: control (C), cisplatin (CS), cisplatin ... -
Ultra-structural changes and apoptotic activity in cerebellum of post-menopausal-diabetic rats: a histochemical and ultra-structural study
Kara, Adem; Ünal, Deniz; Şimşek, Nejdet; Yücel, Atakan; Yücel, Nermin; Selli, Jale (Informa Healthcare, 2014)Diabetes mellitus (DM) is one of the most common and chronic diseases, especially in postmenopausal periods. Neuro-degeneration occurs more frequently in post-menopausal diabetics. Therefore, we investigated ovariectomized ...
