Browsing by Author "Avcıkurt, Ayla Solmaz"
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AGR2 gene expression in glioblastoma: A novel molecular potential target for diagnosis and treatment
Adilay, Hüseyin Utku; Evran, Şevket; Katar, Salim; Özdemir, Ahmet; Kayhan, Ahmet; Avcıkurt, Ayla Solmaz; Günaldı, Ömür; Güçlü, Bülent; Tanrıverdi, Osman (Turkish Neurosurgical Society, 2023)AIM: To assess anterior gradient protein 2 (AGR2) gene expression in patients with human glioblastoma (GBM) in comparison to levels in healthy brain tissues. MATERIAL and METHODS: We evaluated the expression levels of AGR2 ... -
Anjiogenezis etkili faktörlerin karbonik anhidraz IX Gen ekspresyonuna etkilerinin belirlenmesi
Avcıkurt, Ayla Solmaz (Balıkesir Üniversitesi Fen Bilimleri Enstitüsü, 2014)Karbonik Anhidraz IX katı tümörlü hücrelerde ifadesi olan Karbonik Anhidraz ailesinin bir üyesidir. CAIX'un ekspresyonu bir çok kanser türünde hastalık süreci ile ilişkilidir. Kanser ile ilişkili olan CAIX geninin ... -
Antidepressant and antipsychotic drugs differentially affect pon1 enzyme activity
Avcıkurt, Ayla Solmaz; Sinan, Selma; Köçkar, Feray (Taylor & Francis Ltd, 2015)Human serum paraoxonase (PON1, EC 3.1.8.1.) is a high-density lipid (HDL)-associated, calcium-dependent enzyme. In this study, the effects of Haloperidol, Fluoxetine hydrochloride, Diazepam and Acepromazine drugs used for ... -
Astım hastalığında IL-18 gen polimirfiziminin araştırılması
Ocak, Nil (Balıkesir Üniversitesi Fen Bilimleri Enstitüsü, 2018)Genetik ve çevresel faktörlerin etkisi ile oluşan astım, solunum yollarında obstrüksiyon ile giden bir hastalıktır. Doğuştan ve edinilmiş bağışıklık sisteminin önemli düzenleyicisi olan IL-18, insanda kromozom 11q22.2-2-q22.3 ... -
Bazı ilaçların paraoksonaz izoenzimleri (PON1 ve PON2) üzerine etkilerinin belirlenmesi
Avcıkurt, Ayla Solmaz (Balıkesir Üniversitesi Fen Bilimleri Enstitüsü, 2009)Bu çalışmanın amacı, bazı ilaçların, fizyolojik ve pato-fizyolojik durumlarda önemleri belirlenmiş PON1 ve PON2 enzimleri üzerinde in vitro etkilerinin belirlenmesidir. Çalışma, günümüzde kullanımı artan antidepresan ve ... -
The determination of effect of some antibiotics on paraoxonase 2 (PON2) enzyme activities in human macrophages cell
Avcıkurt, Ayla Solmaz; Köçkar, Feray; Sinan, Selma (Wiley-Blackwell, 2015)The human paraoxonase (hPON) gene family includes threemembers: PON1, PON2, and PON3, located adjacent to eachother on the long arm of chromosome 7. The three hPONs shareapproximately 65% identity at the amino acid level ... -
Discoid meniscus: High levels of apoptotic and autophagic genes
Atik, Aziz; Avcıkurt, Ayla Solmaz; Sargın, Serdar (Wolters Kluwer Medknow Publications, 2021)Background: How the meniscus adapts to the morphological changes in the lateral tibiofemoral compartment, in terms of gene expression, was the reason to establish this present study. Objective: This study aimed to determine ... -
Effect of certain non-steroidal anti-inflammatory drugs on the paraoxonase 2 (pon2) in human monocytic cell line u937
Avcıkurt, Ayla Solmaz; Korkut, Oğuzhan (Taylor & Francis Ltd, 2018)The paraoxonase gene family in humans consists of three members as PON1, PON2 and PON3. PON2 can be expressed in several tissues; however, it is not released from the cells in those tissues. PON2 is also expressed in ... -
Effects of epidermal growth factor (egf) on caıx and caxıı expression ın mg-63 cells
Avcıkurt, Ayla Solmaz; Köçkar, Feray (Wiley-Blackwell, 2015)Carbonic anhydrases catalyse the reversible reaction from H2Oand CO2to HCO3-ions. Carbonic Anhydrase IX and CarbonicAnhydrase XII are member of the carbonic anhydrase family.Carbonic Anhydrase IX and Carbonic Anhydrase XII ... -
Effects of oral antidiabetic metformin on hepatocellular cancer cells
Avcıkurt, Ayla Solmaz; Altun, Eren (Cukurova Univ, 2018)Purpose: In this study, the effects of the oral antidiabetic metformin on cell proliferation on human hepatocellular carcinoma cell line (Hep3B) at 4 different doses and at 4 different time intervals were determined. ... -
Effects of vascular endothelial growth factor (VEGF) on CAIX expression in Hep3B cells
Avcıkurt, Ayla Solmaz; Köçkar, Feray; Yıldırım, Hatice (Wiley-Blackwell, 2012)Zinc containing carbonic anhydrase enzymes have important rolesin different physiological processes as gas exchange, ion transportand acid-base balance. Carbonic anhydrases catalyse the reversiblereaction from H2OandCO2to ... -
Hatmi çiçeği (Althaea officinalis L.)'nin prostat kanserinde hücre canlılığı, göçü ve apoptoz üzerine etkileri
Atalay, Mustafa Said (Balıkesir Üniversitesi Fen Bilimleri Enstitüsü, 2021)En sık görülen kanser türlerinden biri olan prostat kanseri, erkeklerde kansere bağlı ölümlerde ikinci sırada yer almaktadır. Bitkisel ilaçların kanser aktive edici enzimleri ve hormonları inhibe etmek, DNA onarım mekanizmasını ... -
HIV/AIDS awareness and attitudes of tour guides in Turkey
Avcıkurt, Cevdet; Köroğlu, Özlem; Köroğlu, Ahmet; Avcıkurt, Ayla Solmaz (Routledge Journals, 2011)The aim of this study was to ascertain Turkish tour guides' awareness and attitudes regarding HIV and AIDS. A sample of 516 tour guides registered in Turkey who verbally consented to participate in this study responded to ... -
Importance of MACC1 expression in breast cancer and its relationship with pathological prognostic markers
Söyleyici, Nevroz Alış; Aslan, Figen; Avcıkurt, Ayla Solmaz; Akgün, Gizem Akkaş (Wolters Kluwer Medknow Publications, 2020)Background: Metastasis associated colon cancer gene 1 (MACC1) is a gene that was first described as a c-Met transcription regulator causing the progression of colon cancer. In this study, protein and messenger RNA (mRNA) ... -
Q192R polymorphism in the PON1 gene and nasal polyp in a Turkish population
Avcıkurt, Ayla Solmaz; Gencer, Nahit; Yazıcı, Haşmet (Wiley, 2020)The pathogenesis of nasal polyps is not completely understood. Oxidative damage contributes to polyp formation in the nasal mucosa. The paraoxonase 1 (PON1) enzyme is an important liver enzyme with high antioxidant activity. ... -
Relationship between CIP2A and endometrium cancer
Aslan, Figen; Güney, Gürhan; Avcıkurt, Ayla Solmaz; Taşkın, Mine İslimye; Akgün, Gizem Akkaş (Coll Physicians & Surgeons Pakistan, 2020)Objective: To determine whether there is a relationship between endometrium cancer and the oncoprotein cancerous inhibitor of protein phosphatase 2A (CIP2A). Study Design: A descriptive study. Place and Duration of ... -
Role of AGR2 expression in specimens from pituitary adenoma tissue on tumor behavior
Doğanşen, Sema Çiftçi; Günaldı, Ömür; Avcıkurt, Ayla Solmaz; Çolluoğlu, Barış; Yılmaz, İlhan (Turkiye Klinikleri, 2020)Objective: To investigate the anterior gradient 2 (AGR2) mRNA expression, which performs various cellular functions such as cell migration, differentiation, and proliferation in tissue specimens from pituitary adenomas. ... -
Ubiquitin-specific protease 8 gene expression in sporadic pituitary adenomas
Hatipoğlu, Esra; Günaldı, Ömür; Erkan, Buruç; Avcıkurt, Ayla Solmaz; Mert, Meral; Niyazoğlu, Mutlu (Maghira & Maas Publications, 2022)OBJECTIVES: In sporadic pituitary adenomas, the role of Ubiquitin-specific protease 8 (USP8) is not clearly defined. Mutations in USP8 gene are known to influence formation of the corticotroph adenomas. However, it has not ... -
URG4 expression in invasive breast carcinoma and its relation to clinicopathological characteristics
Aslan, Figen; Avcıkurt, Ayla Solmaz (Springer Japan, 2019)BackgroundUpregulated gene 4 (URG4) is a recently described oncogene that upregulates cell proliferation. Its overexpression has been identified in many malignancies, and it is thought to be related to tumour progression, ...
