Browsing by Author "Bilen, Çiğdem"
Now showing items 1-20 of 23
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Alkalen fosfataz enziminin saflaştırılması ve bazı ilaçlara karşı afinitesinin araştırılması
Bilen, Çiğdem (Balıkesir Üniversitesi Fen Bilimleri Enstitüsü, 2015)Bu çalışmada, fosfat metabolizmasında önemli role sahip olan Alkalen Fosfatazın (ALP), sütte pastörizasyon belirteci olarak kullanılması gerekçesiyle sütte bulunan izoformu biyokimyasal yöntemlerle saflaştırılmış ve bazı ... -
Antipsychotic agents screened as human carbonic anhydrase I and II inhibitors
Erzengin, Mahmut; Bilen, Çiğdem; Ergün, Adem; Gençer, Nahit (Informa Healthcare, 2014)The antipsychotic drugs currently used to treat schizophrenia can be divided into two distinct classes, typical and atypical antipsychotics. Many drug molecules are enzyme inhibitors that bind reversibly or irreversibly ... -
Coumarin or benzoxazinone based novel carbonic anhydrase inhibitors: synthesis, molecular docking and anticonvulsant studies
Karataş, Mert Olgun; Uslu, Harun; Sarı, Suat; Alagöz, Mehmet Abdullah; Karakurt, Arzu; Alıcı, Bülent; Bilen, Çiğdem; Yavuz, Emre (Taylor & Francis Inc, 2016)Among many others, coumarin derivatives are known to show human carbonic anhydrase (hCA) inhibitory activity. Since hCA inhibition is one of the underlying mechanisms that account for the activities of some antiepileptic ... -
The effects of anti-epileptic drugs on human erythrocyte carbonic anhydrase I and II isozymes
Koç, Emine Rabia; Erken, Gülten; Bilen, Çiğdem; Sackes, Zübeyde; Gencer, Nahit (Taylor & Francis Ltd, 2014)Carbonic anhydrase (CA) is an enzyme which plays a role in various homeostatic mechanisms, such as acid-base balance and electrolyte secretion in a various tissues. This study was aimed at determining and comparing possible ... -
The effects of bronchodilator drugs and antibiotics used for respiratory infection on human erythrocyte carbonic anhydrase I and II isozymes
Sarıoğlu, Nurhan; Bilen, Çiğdem; Saçkes, Zübeyde; Gencer, Nahit (Taylor & Francis Ltd, 2015)Carbonic anhydrase (CA) is an enzyme which plays role/roles in various homeostatic mechanisms, such as the acid-base balance and electrolyte secretion in various tissues. This study aimed to determine and to compare possible ... -
The effects of ex vivo ozone treatment on erythrocyte carbonic anhydrase enzyme
Erken, Gülten; Erken, Haydar Ali; Bilen, Çiğdem; Gencer, Nahit (Wiley-Blackwell, 2015)AIM: Medical ozone generates beneficial effects by stimulating the endogenous antioxidant systems. Carbonic anhydrases (CAs, EC 4.2.1.1.) are metalloenzymes and play a significant role in acid-base regulation. The aim of ... -
Extraction and biological activity of total anthocyanins from sweet cherry cultivars as polyphenol oxidase inhibitors
Demir, Taki; Sönmez, Fatih; Bilen, Çiğdem; Gençer, Nahit (WFL Publisher Ltd., 2013)Total anthocyanins were extracted from six sweet cherry cultivars grown in Sakarya, Turkey, and their inhibitory effects on the diphenolase activity of banana polyphenol oxidase (PPO) were evaluated. The PPO was purified ... -
In vitro effects of estrogen and progesterone containing drugs on human erythrocyte carbonic anhydrase I and II isozymes in women smokers and nonsmokers
Taşkın, Mine İslimye; Bilen, Çiğdem; Ergün, Adem; Gencer, Nahit; İnceboz, Ümit (Elsevier Taiwan, 2015)Background: Carbonic anhydrases (CAs), a group of metalloenzymes, are involved in numerous physiological and pathological processes such as acid base balance, gluconeogenesis, lipogenesis, ureagenesis, electrolyte secretion ... -
In vitro inhibition effect and structure-activity relationships of some saccharin derivatives on erythrocyte carbonic anhydrase I and II
Sönmez, Fatih; Bilen, Çiğdem; Sümersan, Sinem; Gençer, Nahit; Işık, Semra; Arslan, Oktay; Küçükislamoğlu, Mustafa (Taylor & Francis Ltd, 2014)In this study, in vitro inhibitory effects of some saccharin derivatives on purified carbonic anhydrase I and II were investigated using CO2 as a substrate. The results showed that all compounds inhibited the hCA I and hCA ... -
In vitro inhibition effect of some chalcones on erythrocyte carbonic anhydrase i and II
Gençer, Nahit; Bilen, Çiğdem; Demir, Dudu; Atahan, Alparslan; Ceylan, Mustafa; Küçükislamoğlu, Mustafa (Informa Healthcare, 2013)In this study, 4'-(phenylurenyl/thiourenyl) chalcones (14-25) were prepared from 4'-(phenylurenyl/thiourenyl)acetophenones and benzaldehyde derivatives by Claisen-Schmidt condensation. In vitro inhibition effects of chalcone ... -
Inhibition of carbonic anhydrase I and II with total anthocyanins extracted from sweet cherry cultivars
Demir, Taki; Güneşli, Zuhal; Sönmez, Fatih; Bilen, Çiğdem; Yavuz, Emre; Gencer, Nahit (GH Asachi Technical Univ IASI, 2015)Total anthocyanins were extracted from six sweet cherry cultivars grown in Sakarya, Turkey. In vitro inhibition effects of the extracted total anthocyanins on purified carbonic anhydrase I and II were investigated using ... -
Investigation of heavy metal effects on immobilized paraoxanase by glutaraldehyde
Bilen, Çiğdem; Beyaztaş, Serap; Arslan, Oktay; Güler, Özen Özensoy (Informa Healthcare, 2013)Serum paraoxonase 1 (PON1) was purified from bovine serum using hydrophobic interaction chromotography on Sepharose 4B-coupled L-tyrosine 1-naphthylamine gel, and monitored by sodium dodecyl sulfate polyacrylamide gel ... -
Paraoksonaz enziminin glutaraldehit ile immobilizasyonu ve bazı ağır metallere karşı afinitesinin araştırılması
Bilen, Çiğdem (Balıkesir Üniversitesi Fen Bilimleri Enstitüsü, 2009)Bu çalışmada, ilk olarak sığır serum PON1 enzimini saflaştırmak amacıyla Sepharose 4B L-tirozin 1-naftilamin kimyasal yapısındaki hidrofobik etkileşim kromatografi jeli kullanılmış ve PON1 enzimi saflaştırılmıştır. SDS-PAGE ... -
Paraoxonase activity and phenotype distribution in patients with chronic obstructive pulmonary disease
Sarıoğlu, Nurhan; Bilen, Çiğdem; Çevik, Celalettin; Gencer, Nahit (AVES, 2020)Objective: Paraoxonase 1 (PON1) and arylesterase (ARE) enzymes have an important role in the prevention of oxidative stress which is related to the pathogenesis of chronic obstructive pulmonary disease (COPD). PON1 levels ... -
Synthesis and biological evaluation of new 4-thiazolidinone derivatives as carbonic anhydrase inhibitors
Genç, Hayriye; Çeken, Büşra; Bilen, Çiğdem; Saçkes, Zübeyde; Gencer, Nahit; Arslan, Oktay (Bentham Science Publ Ltd, 2017)Background: The catalytically active site of CA enzyme is Zn (II) bound hydroxide ion part which acts as a strong nucleophile (at neutral pH) on the CO2 molecule bound in a hydrophobic pocket nearby. We designed a series ... -
Synthesis and carbonic anhydrase inhibitory properties of 1,3-dicarbonyl derivatives of methylaminobenzene-sulfonamide
Demirci, Tuna; Arslan, Mustafa; Bilen, Çiğdem; Demir, Dudu; Gençer, Nahit; Arslan, Oktay (Informa Healthcare, 2014)1,3-Dicarbonyl derivatives of methylaminobenzene-sulfonamide were synthesized and their inhibitory effects on the activity of purified human carbonic anhydrase (hCA) I and hCA II were evaluated. hCA I and hCA II from human ... -
Synthesis and carbonic anhydrase inhibitory properties of new spiroindoline-substituted sulphonamide compounds
Güleç, Özcan; Arslan, Mustafa; Gencer, Nahit; Ergün, Adem; Bilen, Çiğdem; Arslan, Oktay (Taylor & Francis Ltd, 2017)New spiroindoline-substituted sulphonamide compounds were synthesised and their inhibitory effects on the activity of purified human carbonic anhydrase I and II were evaluated. Human carbonic anhydrase isoenzymes (hCA-I ... -
Synthesis and evaluation of n-heteroarylsubstituted triazolosulfonamides as carbonic anhydrase inhibitors
Balcı, Ahmet; Arslan, Mustafa; Nixha, Arleta Rifati; Bilen, Çiğdem; Ergün, Adem; Gencer, Nahit (Taylor & Francis Ltd, 2015)A new series of N-heteroarylsubstituted triazolosulfonamide compounds were synthesized and their inhibitory effects on the activity of purified human carbonic anhydrase (hCA) I and II were evaluated. Compounds (3 a-k) were ... -
Synthesis and evaluation of new phthalazine substituted beta-lactam derivatives as carbonic anhydrase inhibitors
Berber, Nurcan; Arslan, Mustafa; Bilen, Çiğdem; Saçkes, Zübeyde; Gencer, Nahit; Arslan, Oktay (Maik Nauka / Interperiodica / Springer, 2015)A new series of phthalazine substituted beta-lactam derivatives were synthesized and their inhibitory effects on the activity of purified human carbonic anhydrase (hCA I and II) were evaluated. 2H-Indazolo[2,1-b]phthalazine-trione ... -
Synthesis and in vitro inhibition effect of new pyrido[2,3-d] pyrimidine derivatives on erythrocyte carbonic anhydrase i and ii
Kuday, Hilal; Sönmez, Fatih; Bilen, Çiğdem; Yavuz, Emre; Gençer, Nahit; Küçükislamoğlu, Mustafa (Hindawi Publishing Corporation, 2014)In vitro inhibition effects of indolylchalcones and new pyrido[2,3-d] pyrimidine derivatives on purified human carbonic anhydrase I and II (hCA I and II) were investigated by using CO2 as a substrate. The results showed ...
