Browsing by Author "Bozdağ, Murat"
Now showing items 1-5 of 5
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7-amino-3,4-dihydro-1h-quinolin-2-one, a compound similar to the substituted coumarins, inhibits alpha-carbonic anhydrases without hydrolysis of the lactam ring
Vullo, Daniela; Işık, Semra; Bozdağ, Murat; Carta, Fabrizio; Supuran, Claudiu T. (Taylor & Francis Ltd, 2015)7-Amino-3,4-dihydro-1H-quinolin-2-one, a compound structurally similar to coumarins, recently discovered class of inhibitors of the alpha-carbonic anhydrases (CAs, EC 4.2.1.1) was investigated for its interaction with all ... -
Nükleik asit tayinine yönelik elektrokimyasal genosensör dizaynı
Bozdağ, Murat (Balıkesir Üniversitesi Fen Bilimleri Enstitüsü, 2010)Günümüzde, LNA probların elektrokimyasal hibridizasyon analizi geliştirmesinde kullanımı giderek artmaktadır. RNA benzeri bir nükleik asit olan LNA, riboz şekerinin furanoz halkasının kimyasal olarak 2´oksijeni ile 4´ ... -
Privileged scaffolds in medicinal chemistry: Studies on pyrazolo[1,5-a]pyrimidines on sulfonamide containing Carbonic Anhydrase inhibitors
Gümüş, Arzu; Bozdağ, Murat; Angeli, Andrea; Peat, Thomas S.; Carta, Fabrizio; Supuran, Claudiu T.; Selleri, Silvia (Pergamon-Elsevier Science Ltd, 2021)We report for the first time a small series of compounds endowed in vitro with inhibitory properties for the human (h) expressed Carbonic Anhydrase (CAs, E.C. 4.2.1.1) enzymes of physiological interest (i.e. I, II, VA, IX ... -
Synthesis of a novel affinity gel for the purification of carbonic anhydrases
Bozdağ, Murat; Işık, Semra; Beyaztaş, Serap; Arslan, Oktay; Supuran, Claudiu T. (Taylor & Francis Ltd, 2015)A new affinity gel was synthesized for the purification of carbonic anhydrase (CA, EC 4.2.1.1) isozymes from erythrocytes. The gel was prepared on a Sepharose 4B matrix on which a spacer arm based on ethylenediamine was ... -
Thiosemicarbazide-substituted coumarins as selective inhibitors of the tumor associated human carbonic anhydrases IX and XII
Gümüş, Arzu; Bozdağ, Murat; Akdemir, Atilla; Angeli, Andrea; Selleri, Silvia; Carta, Fabrizio; Supuran, Claudiu T. (MDPI, 2022)A novel series of thiosemicarbazide-substituted coumarins was synthesized and the inhibitory effects against four physiologically relevant carbonic anhydrase isoforms I, II, IX and XII showed selective activities on the ...
