Browsing by Author "Bulmuş, Özgür"

Asprosin, a novel therapeutic candidate for painful neuropathy: An experimental study in mice

Özcan, Sibel; Kelestemur, Muhammed Miraç; Hekim, Müğnevver Gizem; Bulmuş, Özgür; Bulut, Ferah; Bilgin, Batuhan; Canpolat, Sinan (Springer, 2022)

Recent studies indicate presence of a strong link between adipokines and neuropathic pain. However, the effects of asprosin, a novel adipokine, on neuropathic pain have not been studied in animal models. Mouse models were ...

Effect of agomelatine on intestinal smooth muscle contractility in rats

Kaçar, Emine; Şahintürk, Serdar; Yardımcı, Ahmet; Ülker, Nazife; Tan, Fatih; Bulmuş, Özgür; Ercan, Zübeyde (İnönü Üniversitesi Tıp Fakültesi, 2022)

Aim: The purpose of the present study was to investigate in vitro the effect of agomelatine, an analog of melatonin, on potassium chloride-stimulated contractions (KCl) in duodenum, jejunum, ileum, and colon in ...

The effect of irisin hormone on motor function in thorocal spinal cord injury model

Doğru, Meryem Sedef; Yılmaz, Seçil; Özdede, Mehmet Rıdvan; Bilek, Furkan; Bulmuş, Özgür; Ercan, Zübeyde (Wiley, 2023)

Özet bilgisi yok.

Effect of metaclopramide on urinary bladder smooth muscle contraction-relaxation mechanism

Ercan, Zübeyde; Zorlu, Gökhan; Bulmuş, Özgür; Serhatlıoğlu, İhsan; Yaşar, Abdullah; Kaçar, Emine (2022)

Objectives: Metoclopramide, a dopamine receptor antagonist, a benzamide, is a commonly used antiemetic drug in many diseases with nausea and vomiting. The aim of this study is to examine the effects of metoclopramide, which ...

Effects of coenzyme Q10, fullerene C60, and αlpha-lipoic acid on histomorphometric, antiapoptotic and ınsulin expression in pancreatic tissue of rats exposed to bisphenol A

Çeribaşı, Songül; Yüce, Abdurrauf; Bulmuş, Özgür (Prof.Dr. Mustafa İssi, 2024)

The aim of this study was to determine the morphometric changes in the pancreas, apoptosis related pancreatic damage, and differences in insulin expression in male rats exposed to low doses of BPA from early pubertal ...

The effects of irisin hormone on seminal vesicle fluid in male rats administered paroxetine

Bulmuş, Özgür; Bulmuş, Funda Gülcü; Serhatlıoğlu, İhsan; Canpolat, Sinan (Wiley, 2023)

It is known that antidepressants cause some negative effects in the reproductive system and especially in sperm parameters. It is stated that exercise is an effective factor on the transition to puberty, reproductive ...

Effects of ramelteon on myometrial contractions in rats

Çoban, Eda; Bulmuş, Özgür (Karger, 2021)

Meeting Abstract

Effects of treadmill exercise on sexual behavior and reproductive parameters in chronically stressed-male rats

Kelestimur, Haluk; Bulmuş, Özgür; Serhatlıoğlu, İhsan; Ercan, Zübeyde; Kaya, Şeyma Özer; Yardımcı, Ahmet; Ülker, Nazife; Kaçar, Emine; Canpolat, Sinan (Acad Sciences Czech Republic, 2021)

Exposure to chronic stress stimulates the hypothalamic-pituitary adrenal (HPA) axis and then simultaneously inhibits hypothalamic-pituitary-gonadal axis (HPG) axis activity. The inhibition formed by the HPA axis is the ...

Evaluating effects of black carrot extract on testicular carboxylesterase activity and oxidative stress parameters in rats exposed to bisphenol A

Özkaya, Ahmet; Şahin, Zafer; Şahin, Yunus; Bulmuş, Özgür; Uçkun, Miraç; Yoloğlu, Ertan (Adıyaman Üniversitesi, 2021)

We aimed to evaluate the effects of black carrot extract on testicular carboxylesterase (Ces)activity, malondialdehyde (MDA), glutathione S-transferases (GST) and reduced glutathione(GSH) in male rats exposed to bisphenol ...

An evaluation of the effectiveness of melatonin and n-acetylcysteine in cerebral ischemia-reperfusion injury in adult rats

Aydın, Hilal; Bulmuş, Özgür; Korkut, Oğuzhan; Altun, Eren; Ulusal, Ali Engin (MDPI, 2023)

Background and Objectives: The purpose of this study was to apply histopathological and immunohistochemical methods to compare the protective efficacy of melatonin and N-acetylcysteine (NAC) application in rats with ...

Evaluation of the effects of systemic irisin application on guided bone regeneration in peri-implant bone defects

Bulmuş, Özgür; Dündar, Serkan; Bozoğlan, Alihan; Artas, Gökhan; Kirtay, Mustafa; Canpolat, Sinan (Lippincott Williams & Wilkins, 2022)

This study aimed to investigate the effects of systemic irisin hormone application on new bone formation in periimplant bone defects. After surgically creating peri-implant bone defects in the metaphyseal part of the ...

Evaluation of the effects of systemic irisin hormone application on osseointegration of titanium implants: An experimental study

Bulmuş, Özgür; Dündar, Serkan; Bozoğlan, Alihan; Canpolat, Sinan (Lippincott Williams & Wilkins, 2022)

This study aimed to conduct a biomechanical investigation of the effects of systemic irisin hormone application on the osseointegration of titanium implants in rat tibias. After surgical implementation of titanium implants ...

Expression of phoenixin-14 and nesfatin-1 in the hypothalamo-pituitary-gonadal axis in the phases of the estrous cycle

Ak, Tuba Parlak; Yaman, Mine; Bayrakdar, Ali; Bulmuş, Özgür (Churchill Livingstone, 2022)

Phoenixin-14 (PNX-14) and nucleobindin 2 (NUCB2)/nesfatin-1 are regulatory neuropeptides expressed in the hypothalamus. These neuropeptides can be effective in hormonal regulation of the hypothalamo–pituitary–gonadal (HPG) ...

Investigation the effect of ramelteon on urinary bladder smoth muscle contraction-relaxation mechanism

Serhatlıoğlu, İhsan; Hekim, Münevver Gizem; Zorlu, Gökhan; Bulmuş, Özgür; Yaşar, Abdullah; Kaçar, Emine (İnönü Üniversitesi Tıp Fakültesi, 2022)

Aim: A melatonin receptor agonist ramelteon is a drug that is also used in urinary tract infections. Melatonin is known to have an effect on smooth muscle contraction. In this study, we aimed to question whether ramelteon ...

Irisin ameliorates male sexual dysfunction in paroxetine-treated male rats

Canpolat, Sinan; Ülker, Nazife; Yardımcı, Ahmet; Tancan, Emre; Şahin, Elif; Yaman, Serap Özer; Bulmuş, Özgür; Alver, Ahmet; Özcan, Mete (Pergamon-Elsevier Science Ltd, 2021)

Sexual dysfunction is a common clinical condition due to different causes including the use of selective serotonin reuptake inhibitors (SSRI). Especially, SSRI paroxetine is known to cause numerous types of sexual dysfunction ...

Irisin improves high-fat diet-induced sexual dysfunction in obese male rats

Yardımcı, Ahmet; Ülker, Nazife; Bulmuş, Özgür; Şahin, Elif; Alver, Ahmet; Güngör, İbrahim Halil; Türk, Gaffari; Artas, Gökhan; Tektemur, Nalan Kaya (Karger, 2022)

Obesity is known to cause sexual dysfunction including erectile dysfunction and poor semen quality. Lifestyle modifications such as exercise have increasingly been more recognized to lower the likelihood of having sexual ...

Modulation of melatonin receptors regulates reproductive physiology: The impact of agomelatine on the estrus cycle, gestation, offspring, and uterine contractions in rats

Kaçar, Emine; Tan, Fatih; Şahintürk, Serdar; Zorlu, Gökhan; Serhatlıoğlu, İhsan; Bulmuş, Özgür; Ercan, Zübeyde; Keleştimur, Haluk (Acad Sciences Czech Republic, 2023)

Agomelatine is a pharmaceutical compound that functions as an agonist for melatonin receptors, with a particular affinity for the MT1 and MT2 receptor subtypes. Its mode of action is integral to the regulation of diverse ...