Browsing by Author "Carta, Fabrizio"
Now showing items 1-3 of 3
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7-amino-3,4-dihydro-1h-quinolin-2-one, a compound similar to the substituted coumarins, inhibits alpha-carbonic anhydrases without hydrolysis of the lactam ring
Vullo, Daniela; Işık, Semra; Bozdağ, Murat; Carta, Fabrizio; Supuran, Claudiu T. (Taylor & Francis Ltd, 2015)7-Amino-3,4-dihydro-1H-quinolin-2-one, a compound structurally similar to coumarins, recently discovered class of inhibitors of the alpha-carbonic anhydrases (CAs, EC 4.2.1.1) was investigated for its interaction with all ... -
Privileged scaffolds in medicinal chemistry: Studies on pyrazolo[1,5-a]pyrimidines on sulfonamide containing Carbonic Anhydrase inhibitors
Gümüş, Arzu; Bozdağ, Murat; Angeli, Andrea; Peat, Thomas S.; Carta, Fabrizio; Supuran, Claudiu T.; Selleri, Silvia (Pergamon-Elsevier Science Ltd, 2021)We report for the first time a small series of compounds endowed in vitro with inhibitory properties for the human (h) expressed Carbonic Anhydrase (CAs, E.C. 4.2.1.1) enzymes of physiological interest (i.e. I, II, VA, IX ... -
Thiosemicarbazide-substituted coumarins as selective inhibitors of the tumor associated human carbonic anhydrases IX and XII
Gümüş, Arzu; Bozdağ, Murat; Akdemir, Atilla; Angeli, Andrea; Selleri, Silvia; Carta, Fabrizio; Supuran, Claudiu T. (MDPI, 2022)A novel series of thiosemicarbazide-substituted coumarins was synthesized and the inhibitory effects against four physiologically relevant carbonic anhydrase isoforms I, II, IX and XII showed selective activities on the ...
