Browsing by Author "Demir, Dudu"
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An alternative purification method for human serum paraoxonase 1 and its interactions with anabolic compounds
Demir, Dudu; Gencer, Nahit; Arslan, Oktay (Taylor & Francis Ltd, 2016)In this study, an alternative purification method for human paraoxonase 1 (hPON1) enzyme was developed using two-step procedures, namely, ammonium sulfate precipitation and Sepharose-4B-l-tyrosine-3-aminophenantrene ... -
Comparison of serum paraoxonase 1 (pon1) activities among different sheep breeds in Turkey
Arslan, Mikail; Erzengin, Mahmut; Demir, Dudu (Medwell Online, 2011)Paraoxonase 1 (PON1, EC 3.1.8.1) is a calcium dependent mammalian enzyme that is synthesized primarily in the liver and is secreted into the serum where it is associated with High Density Lipoproteins (HDLs) and has a ... -
Evaluation of new chalcone derivatives as polyphenol oxidase inhibitors
Sönmez, Fatih; Sevmezler, Sedat; Atahan, Alparslan; Ceylan, Mustafa; Demir, Dudu; Gençer, Nahit; Arslan, Oktay; Küçükislamoğlu, Mustafa (Pergamon-Elsevier Science Ltd, 2011)A newly series of 4-(phenylurenyl) chalcone (4a-j) and 4'-(phenylurenyl/thiourenyl)chalcone (9a-l) derivatives were synthesized and their inhibitory effects on the diphenolase activity of banana tyrosinase were evaluated. ... -
Farklı sıcaklıklarda etilen glikol metil eter türevlerinin fiziksel özellikleri
Demir, Dudu (Balıkesir Üniversitesi Fen Bilimleri Enstitüsü, 2007)Bu çalışmada, 293.15K - 333.15K sıcaklık aralığında, atmosferik basınçta (Pegdme 250 + etanol/1-propanol/2-propanol/1-bütanol) ve (Pegmme 350 + etanol/1-propanol/2-propanol/1-bütanol/metanol) ikili karışımları için kırma ... -
In vitro effects of some anabolic compounds on erythrocyte carbonic anhydrase I and II
Gençer, Nahit; Ergün, Adem; Demir, Dudu (Informa Healthcare, 2012)The in vitro effects of the anabolic compounds, zeranol, 17 beta-estradiol, diethylstilbestrol (DES), and trenbolone, on the activity of purified human carbonic anhydrase I and II were evaluated. In vitro CA enzyme activity ... -
In vitro effects of some herbicides and fungicides on human erythrocyte carbonic anhydrase activity
Gençer, Nahit; Ergün, Adem; Demir, Dudu (Parlar Scientific Publications (P S P), 2012)The effects of Imazethapyr, 2,4-D dimethylamine salt, Glyphosate isopropylamine salt and Propamocarb HCl, which are commonly used in agricultural fields, have been investigated on human erythrocyte carbonic anhydrase ... -
In vitro inhibition effect of some chalcones on erythrocyte carbonic anhydrase i and II
Gençer, Nahit; Bilen, Çiğdem; Demir, Dudu; Atahan, Alparslan; Ceylan, Mustafa; Küçükislamoğlu, Mustafa (Informa Healthcare, 2013)In this study, 4'-(phenylurenyl/thiourenyl) chalcones (14-25) were prepared from 4'-(phenylurenyl/thiourenyl)acetophenones and benzaldehyde derivatives by Claisen-Schmidt condensation. In vitro inhibition effects of chalcone ... -
In vitro inhibition of polyphenol oxidase by some new diarylureas
Demir, Dudu; Gençer, Nahit; Arslan, Oktay; Genç, Hayriye; Zengin, Mustafa (Informa Healthcare, 2012)A new series of N,N'-diarylureas (1-9) was synthesized. These compounds were investigated as inhibitors of polyphenol oxidase (PPO) which had been purified from banana by an affinity gel comprised of Sepharose 4B-L-tyros ... -
New coumarin derivatives as carbonic anhydrase inhibitors
Karataş, Mert Olgun; Alıcı, Bülent; Çakır, Ümit; Çetinkaya, Engin; Demir, Dudu; Ergün, Adem; Gençer, Nahit; Arslan, Oktay (Taylor & Francis Ltd, 2014)In the current study, a series of 4-chloromethyl-7-hydroxy-coumarin derivatives containing imidazolium, benzimidazolium, bisbenzimidazolium and quaternary ammonium salts were synthesized, characterized and the inhibition ... -
New saccharin derivatives as tyrosinase inhibitors
Gençer, Nahit; Demir, Dudu; Sönmez, Fatih; Küçükislamoğlu, Mustafa (Pergamon-Elsevier Science Ltd, 2012)A newly series of 6-(phenylurenyl/thiourenyl) saccharin (6a-y) derivatives were synthesized and their inhibitory effects on the diphenolase activity of banana tyrosinase were evaluated. A 70-fold purification of the enzyme ... -
Novel purification strategy for paraoxonase enzyme
Demir, Dudu; Gençer, Nahit; Arslan, Oktay (Wiley-Blackwell, 2011)Human serum paraoxonase (PON1, EC 3.1.8.1.) is a high-den-sity lipid (HDL)-associated, calcium-dependent enzyme; its physi-ological substrates are not known. Paraoxonase bound to HDLis an important liver enzyme responsible ... -
Novel β-lactam compounds as activators for polyphenoloxidase
Bytyqi-Damoni, Arlinda; Genç, Hayriye; Zengin, Mustafa; Demir, Dudu; Gencer, Nahit; Arslan, Oktay (Wiley V C H Verlag GMBH, 2020)A copper-containing enzyme polyphenol oxidase (other name is tyrosinase) plays crucial role in melanin biosynthesis, as a compound responsible for human pigmentation. Non controlled loss of melanin can cause hypopigmentation ... -
Paraoxonase 1 phenotype and paraoxonase activity in asthmatic patients
Sarıoğlu, Nurhan; Hismioğulları, Adnan Adil; Gencer, Nahit; Erel, Fuat; Demir, Dudu (Iranian Scientific Society Medical Entomology, 2015)Oxidative stress is involved in the pathogenesis of asthma. Paraoxonase 1 (PON1) and arylesterase are esterase enzymes displaying antioxidant characteristics. PON1 activity varies widely among individuals and ethnic groups, ... -
Paraoxonase 1-bound magnetic nanoparticles: Preparation and characterizations
Köçkar, Feray; Beyaz, Seda; Sinan, Selma; Köçkar, Hakan; Demir, Dudu; Eryılmaz, Seda; Tanrısever, Taner; Arslan, Oktay (Amer Scientific Publishers, 2010)This is most probably the first time that covalently binding of Human serum paraoxonase 1 (PON1) to superparamagnetic magnetite nanoparticles via carbodiimide activation was investigated and presented in this study. PON1 ... -
Purification and characterization of paraoxonase 1 (pon1) from swiss black, holstein, and montofon bovines
Erzengin, Mahmut; Demir, Dudu; Arslan, Mikail; Sinan, Selma (Humana Press Inc, 2014)Paraoxonase 1 (PON1: EC 3.1.8.1) is a calcium-dependent enzyme associated with high-density lipoproteins (HDLs) and has a protective effect against oxidation of low-density lipoproteins (LDLs) in mammals. PON1 is the ... -
Purification and characterization of prophenoloxidase from Galleria mellonella L.
Demir, Dudu; Gençer, Nahit; Er, Aylin (Informa Healthcare, 2012)Prophenoloxidase (PPO) was purified from Galleria mellonella L. A 67-fold purification of the proenzyme with 352% yield was achieved by using a Sepharose 4B-L-tyrosine-p-amino benzoic acid affinity column. The purified ... -
Synthesis and carbonic anhydrase inhibitory properties of 1,3-dicarbonyl derivatives of methylaminobenzene-sulfonamide
Demirci, Tuna; Arslan, Mustafa; Bilen, Çiğdem; Demir, Dudu; Gençer, Nahit; Arslan, Oktay (Informa Healthcare, 2014)1,3-Dicarbonyl derivatives of methylaminobenzene-sulfonamide were synthesized and their inhibitory effects on the activity of purified human carbonic anhydrase (hCA) I and hCA II were evaluated. hCA I and hCA II from human ... -
Synthesis and carbonic anhydrase inhibitory properties of novel 1,4-dihydropyrimidinone substituted diarylureas
Çelik, Fatma; Arslan, Mustafa; Yavuz, Emre; Demir, Dudu; Gençer, Nahit (Taylor & Francis Ltd, 2014)A new series of 1,4-dihydropyrimidinone (DHPM) substituted diaryl urea and thiourea derivatives were synthesized and their inhibitory effects on the activity of purified human carbonic anhydrase (hCA) I and II were evaluated. ... -
Synthesis and carbonic anhydrase inhibitory properties of novel coumarin derivatives
Karataş, Mert Olgun; Alıcı, Bülent; Çakır, Ümit; Çetinkaya, Engin; Demir, Dudu; Ergün, Adem; Gençer, Nahit; Arslan, Oktay (Informa Healthcare, 2013)A newly series of water-soluble 1-alkyl-3-(4-methyl-7, 8-dihydroxy-2H-chromen-2-one) benzimidazolium chloride salts (3a-j) were synthesized and their inhibitory effects on the activity of purified human carbonic anhydrase ... -
Synthesis, structure-activity relationships and biological activity of new isatin derivatives as tyrosinase ınhibitors
Gençer, Nahit; Sönmez, Fatih; Demir, Dudu; Arslan, Oktay; Küçükislamoğlu, Mustafa (Bentham Science Publ Ltd, 2014)A newly series of isatin derivatives (6a-t) containing alkyl/aryl urea groups were synthesized and their inhibitory effects on the diphenolase activity of banana tyrosinase were evaluated. Tyrosinase was purified from ...
