Browsing by Author "Ergün, Adem"
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Antipsychotic agents screened as human carbonic anhydrase I and II inhibitors
Erzengin, Mahmut; Bilen, Çiğdem; Ergün, Adem; Gençer, Nahit (Informa Healthcare, 2014)The antipsychotic drugs currently used to treat schizophrenia can be divided into two distinct classes, typical and atypical antipsychotics. Many drug molecules are enzyme inhibitors that bind reversibly or irreversibly ... -
Bazı ilaçların koyun Paraoksonaz-1 üzerindeki etkilerinin araştırılması
Yüksel, Hatice; Ergün, Adem; Arslan, Mikail; Arslan, Oktay (2023)Paraoksonaz-1 (PON1, EC 3.1.8.1) birçok metabolik süreçlerde önemli rollere sahip bir metaloenzimdir. Bu çalışmada Karacabey Merinos koyunundan hidrofobik etkileşim tekniği ile PON1 (mPON1) saflaştırılmıştır. Saf enzim ... -
The effect of total anthocyanins extracted from sweet cherry cultivars on carbonic anhydrases and antioxidant activity
Sönmez, Fatih; Güneşli, Zuhal; Demir, Taki; Çıkrıkcı, Kübra; Ergün, Adem; Gencer, Nahit; Arslan, Oktay (Springer, 2022)Total anthocyanins were extracted from eleven sweet cherry cultivars grown in Sakarya, Turkey. In vitro inhibition effects of extracted total anthocyanins on purified carbonic anhydrase I and II were investigated by using ... -
Effects of four pesticides on broilers glutathione-s-transferase activity
Arslan, Mikail; Tak, Tuğba; Ergün, Adem; Gencer, Nahit; Arslan, Oktay (Parlar Scientific Publications (P S P), 2018)GST is the most important detoxifying enzyme of environmental pollutants, such as carcinogenic matters, heavy metals, some of drugs and pesticides. In this study, hydrophobic gel having a chemical structure of Sepharose ... -
Effects of some pesticides on purified human paraoxonase 1 activity, in vitro
Ergün, Adem (Parlar Scientific Publications (P S P ), 2022)Using pesticides in agriculture is a significant problem for the environment and humans. Human paraoxonase 1 (hPON1) is an antioxidant enzyme associated with HDLs in the blood that hydrolyses some pesticides like paraoxon. ... -
In vitro effects of estrogen and progesterone containing drugs on human erythrocyte carbonic anhydrase I and II isozymes in women smokers and nonsmokers
Taşkın, Mine İslimye; Bilen, Çiğdem; Ergün, Adem; Gencer, Nahit; İnceboz, Ümit (Elsevier Taiwan, 2015)Background: Carbonic anhydrases (CAs), a group of metalloenzymes, are involved in numerous physiological and pathological processes such as acid base balance, gluconeogenesis, lipogenesis, ureagenesis, electrolyte secretion ... -
In vitro effects of some anabolic compounds on erythrocyte carbonic anhydrase I and II
Gençer, Nahit; Ergün, Adem; Demir, Dudu (Informa Healthcare, 2012)The in vitro effects of the anabolic compounds, zeranol, 17 beta-estradiol, diethylstilbestrol (DES), and trenbolone, on the activity of purified human carbonic anhydrase I and II were evaluated. In vitro CA enzyme activity ... -
In vitro effects of some herbicides and fungicides on human erythrocyte carbonic anhydrase activity
Gençer, Nahit; Ergün, Adem; Demir, Dudu (Parlar Scientific Publications (P S P), 2012)The effects of Imazethapyr, 2,4-D dimethylamine salt, Glyphosate isopropylamine salt and Propamocarb HCl, which are commonly used in agricultural fields, have been investigated on human erythrocyte carbonic anhydrase ... -
In vitro inhibition effects on erythrocyte carbonic anhydrase I and II and structure-activity relationships of cumarylthiazole derivatives
Kurt, Belma Zengin; Sönmez, Fatih; Gökçe, Başak; Ergün, Adem; Gencer, Nahit; Demir, Taki; Arslan, Oktay; Küçükislamoğlu, Mustafa (Maik Nauka, 2016)Coumarin and heterocyclic compounds incorporating urea have clinical applications as antiepileptics, diuretics, and antiglaucoma agents due to their carbonic anhydrase inhibitory properties. We investigated inhibition of ... -
Makro halkalı tiyo-crown eterlerin sentezi ve karbonik anhidraz enzimi üzerinde inhibisyon etkilerinin araştırılması
Ergün, Adem (Balıkesir Üniversitesi Fen Bilimleri Enstitüsü, 2011)Bu çalışma iki aşamadan oluşmaktadır. İlk olarak, bazı makro halkalı tiyocrown eterlerin sentezleri gerçekleştirilmiştir. Daha sonra ise bu tiyocrown eterlerin, Arslan ve grubunun sentezlediği sepharose-4B-tirozin-p-am ... -
A new affinity gel for purifing polyphenol oxidase enzyme
Ergün, Adem; Arslan, Oktay (Wiley-Blackwell, 2016)Polyphenol oxidase (PPO) enzyme, sometimes called as phenoloxidase, catecholase, phenolase, catechol oxidase or tyrosinase, isconsidered to be an o-dipenol. PPO (EC 1.14.18.1), a multifunc-tional copper containing ... -
New coumarin derivatives as carbonic anhydrase inhibitors
Karataş, Mert Olgun; Alıcı, Bülent; Çakır, Ümit; Çetinkaya, Engin; Demir, Dudu; Ergün, Adem; Gençer, Nahit; Arslan, Oktay (Taylor & Francis Ltd, 2014)In the current study, a series of 4-chloromethyl-7-hydroxy-coumarin derivatives containing imidazolium, benzimidazolium, bisbenzimidazolium and quaternary ammonium salts were synthesized, characterized and the inhibition ... -
Polifenol oksidaz enziminin saflaştırılması ve bazı bileşiklerin bu enzim üzerindeki etkilerinin araştırılması
Ergün, Adem (Balıkesir Üniversitesi Fen Bilimleri Enstitüsü, 2016)Polifenol oksidaz enzimi, Sepharose 4B-L-tirozin-p-amino benzoik asit afinite kromotagrafisi jeli kullanılıp Musa sapientum var. Cavendishii (Muz) meyvesinden saflaştırılmıştır. Saflaştırdığımız enzimin aktivitesi üzerinde ... -
PON1 enzimi üzerine DT-15-Crown-5 taç eterinin etkisinin araştırılması
Ergün, Adem; Çiçek, Baki (Balıkesir Üniversitesi, 2020)İnsan serum paraoksonaz 1 (PON1, EC3.1.8.1) HDL'ye bağlı olan, aktif bölgesinde kalsiyum içeren, organofosfat ajanlarını ve sinir gazlarını hidroliz eden, LDL'nin oksidasyonu ile lipit peroksitlerin oluşumuna ve bakteri ... -
Synthesis and carbonic anhydrase inhibitory properties of new spiroindoline-substituted sulphonamide compounds
Güleç, Özcan; Arslan, Mustafa; Gencer, Nahit; Ergün, Adem; Bilen, Çiğdem; Arslan, Oktay (Taylor & Francis Ltd, 2017)New spiroindoline-substituted sulphonamide compounds were synthesised and their inhibitory effects on the activity of purified human carbonic anhydrase I and II were evaluated. Human carbonic anhydrase isoenzymes (hCA-I ... -
Synthesis and carbonic anhydrase inhibitory properties of novel coumarin derivatives
Karataş, Mert Olgun; Alıcı, Bülent; Çakır, Ümit; Çetinkaya, Engin; Demir, Dudu; Ergün, Adem; Gençer, Nahit; Arslan, Oktay (Informa Healthcare, 2013)A newly series of water-soluble 1-alkyl-3-(4-methyl-7, 8-dihydroxy-2H-chromen-2-one) benzimidazolium chloride salts (3a-j) were synthesized and their inhibitory effects on the activity of purified human carbonic anhydrase ... -
Synthesis and evaluation in vitro effects of some macrocyclic thiacrown ethers on erythrocyte carbonic anhydrase I and II
Çiçek, Baki; Ergün, Adem; Gençer, Nahit (Asian Journal of Chemistry, 2012)A new series of macrocyclic thiacrown ethers (A1-6) were synthesized. These compounds were investigated as erythrocyte carbonic anhydrase I and II, which had been purified by Sepharose-4B-L-tyrosine-sulfonamide affinity ... -
Synthesis and evaluation of n-heteroarylsubstituted triazolosulfonamides as carbonic anhydrase inhibitors
Balcı, Ahmet; Arslan, Mustafa; Nixha, Arleta Rifati; Bilen, Çiğdem; Ergün, Adem; Gencer, Nahit (Taylor & Francis Ltd, 2015)A new series of N-heteroarylsubstituted triazolosulfonamide compounds were synthesized and their inhibitory effects on the activity of purified human carbonic anhydrase (hCA) I and II were evaluated. Compounds (3 a-k) were ... -
Synthesis and evaluation of sulfonamide-bearing thiazole as carbonic anhydrase isoforms hCA I and hCA II
Kılıçaslan, Soner; Arslan, Mustafa; Rüya, Zeynep; Bilen, Ciğdem; Ergün, Adem; Gençer, Nahit; Arslan, Oktay (Taylor & Francis Inc, 2016)Sulfonamide-bearing thiazole compounds were synthesized and their inhibitory effects on the activity of purified human carbonic anhydrase I and II were evaluated. Human carbonic anhydrase isoenzymes (hCA-I and hCA-II) were ... -
Synthesis and investigation of carbonic anhydrase I and II activity of dihydrobenzo[h]quinazolin-2-yl thiourea compounds
Taşcı, Merve; Arslan, Mustafa; Çıkrıkcı, Kübra; Ergün, Adem; Gençer, Nahit; Arslan, Oktay (Springer, 2023)Thirteen novel compounds in a series of dihydrobenzo[h]quinazolin-2-yl thiourea compounds (7a–m) were synthesized and characterized using FT-IR, 1H, 13C NMR spectroscopy, and elemental analysis. Some inhibition parameters ...
