Browsing by Author "Güney, Gürhan"
Now showing items 1-15 of 15
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ADAMS-1 and ADAMS-9, novel markers in endometriosis
Hişmioğulları, Adnan Adil; Güney, Gürhan; Taşkın, Mine İslimye; Güngörmüş, Berna (Sage, 2021)Objectives: ADAMTS (A Disintegrin And Metalloproteinase with ThromboSpondin repeats) proteinases, which are released outside the cell (soluble) have very critical roles in damage and repair of extracellular matrix (ECM) ... -
Does the addition of metformin to carboplatin treatment decreases ovarian reserve damage associated with carboplatin usage?
Ayhan, Sevgi; Hançerlioğulları, Necati; Güney, Gürhan; Gözükücük, Murat; Çaydere, Muzaffer; Güney, Sergül Selvi; Tokmak, Aytekin; Üstün, Yusuf (BioMed Central Ltd, 2023)Background: We aimed to determine whether adding metformin to carboplatin treatment would reduce the damage to ovarian reserve associated with carboplatin use. Methods: We included 35 adult female non-pregnant albino Wistar ... -
Does the SARS-CoV-2 mRNA vaccine damage the ovarian reserve?
Yıldız, Elif; Timur, Burcu; Güney, Gürhan; Timur, Hakan (Lippincott Williams and Wilkins, 2023)To search whether or not the severe acute respiratory syndrome corona virus-2 (SARS-CoV-2) messenger ribonucleic acid (mRNA) vaccine affects the fertility of women at the 6th months by using AMH, which is an ovarian reserve ... -
Endotrophin as a novel marker in PCOS and its relation with other adipokines and metabolic parameters: a pilot study
Güney, Gürhan; Taşkın, Mine İslimye; Baykan, Özgür; Tezcan, Selin Gül; Sarıkaya, Serkan; Kaya, Cihan; Tolu, Ezgi (Sage Publications Ltd, 2021)Background: Polycystic ovary syndrome is known to be the most common hormonal disorder in women of reproductive age. Current evidence shows that regulatory proteins secreted from the adipose tissue called adipokines may ... -
Evaluation of serum telomerase activity in normal-weight young girls with polycystic ovary syndrome and its relation to metabolic parameters
Ünlü, Cemal; Güney, Gürhan; Ersak, Duygu Tuğrul; Kösem, Arzu; Tarlan, Nurten; Tokmak, Aytekin (Walter De Gruyter GMBH, 2023)Objectives: This study investigated the discriminative value of serum telomerase levels in polycystic ovary syndrome (PCOS) and its relation to metabolic parameters.Methods: Patients aged 16-23 years old who visited an ... -
Granzyme B levels and granzyme B polymorphisms in peripheral blood of patients with endometriosis: a preliminary study
Taşkın, Mine İslimye; Güney, Gürhan; Adalı, Ertan; Hişmioğulları, Adnan Adil; Dodurga, Yavuz; Elmas, Levent (Taylor and Francis Inc, 2020)The chronic course of endometriosis suggests that the immune system may play a role in its aetiology. There may be resistance to cell lysis, as well as an immune defect underlying endometriosis. Granzyme B is a serine ... -
Increase of circulating inflammatory molecules in preeclampsia, an update
Güney, Gürhan; Taşkın, Mine İslimye; Tokmak, Aytekin (John Libbey Eurotext Ltd, 2020)Special hormonal and immunological changes are required for normal pregnancy continuation. To escape from rejection by the maternal immune system, pregnancy needs an optimum environment with the integration and the balance ... -
Neutrophil gelatinase-associated lipocalin serum level: A potential noninvasive biomarker of endometriosis?
Güney, Gürhan; Taşkın, Mine İslimye; Lagana, Antonio Simone; Tolu, Ezgi; Aslan, Figen; Hişmioğulları, Adnan Adil; Kaya, Cihan (Lippincott Williams & Wilkins, 2023)Neutrophil gelatinase-associated lipocalin (NGAL, also known as lipocalin-2) is an acute-phase protein expressed in many tissues and plays a role in cell proliferation, regulation, and epithelial-mesenchymal transformation. ... -
The novel relationship between polycystic ovary syndrome and temporomandibular joint disorders
Yazıcı, Haşmet; Taşkın, Mine İslimye; Güney, Gürhan; Hişmioğulları, Adnan Adil; Arslan, Erhan; Tulacı, Kamil Gökçe (Elsevier, 2020)Introduction: Studies investigating the relationship between sex hormones, inflammatory mediators and joint disorders have reported that sex hormones affect the pathogenesis of joint disorders. We aimed to investigate ... -
Relationship between CIP2A and endometrium cancer
Aslan, Figen; Güney, Gürhan; Avcıkurt, Ayla Solmaz; Taşkın, Mine İslimye; Akgün, Gizem Akkaş (Coll Physicians & Surgeons Pakistan, 2020)Objective: To determine whether there is a relationship between endometrium cancer and the oncoprotein cancerous inhibitor of protein phosphatase 2A (CIP2A). Study Design: A descriptive study. Place and Duration of ... -
The relationship between furin and chronic inflammation in the progression of cervical intraepithelial neoplasia to cancer: A cross-sectional study
Afşar, Selim; Turan, Gülay; Güney, Gürhan; Şahin, Gözde; Talmaç, Merve Aldıkaçtıoğlu; Afşar, Çiğdem Usul (Multidisciplinary Digital Publishing Institute (MDPI), 2023)Objective: The current study aimed to delineate the relationship between furin and chronic inflammation while cervical intraepithelial neoplasia progresses to cancer. Study Design: This cross-sectional study included 81 ... -
The role of ERK-1 and ERK-2 gene polymorphisms in PCOS pathogenesis
Güney, Gürhan; Taşkın, Mine İslimye; Şener, Nazlı; Tolu, Ezgi; Dodurga, Yavuz; Elmas, Levent; Çetin, Orkun; Sarıgül, Cengiz (BMC, 2022)Background: Ovulation is regulated by extracellular signal-regulated kinase-1 (ERK-1) and ERK-2 signaling mechanisms, and ERK-1/2 kinases modulates the function of most of the LH-regulated genes. Defective ERK kinase ... -
The role of inflammatory markers hs-CRP, sialic acid, and IL-6 in the pathogenesis of preeclampsia and intrauterine growth restriction
Kara, Ayşe Ekin; Güney, Gürhan; Tokmak, Aytekin; Özakşit, Gülnur (John Libbey Eurotext LTD, 2019)Objective: The aim of our study was to evaluate serum high-sensitivity C-Reactive Protein (hs-CRP), sialic acid (SA), and interleukin-6 (IL-6) levels in pregnancies complicated with preeclampsia (PE) and intrauterine growth ... -
The role of serum ADAMTS-1 levels in hyperemesis gravidarum
Timur, Burcu; Güney, Gürhan (BMC, 2022)Background: We aimed to investigate the levels of ADAMTS-1, which is secreted from the extracellular matrix during trophoblastic invasion in hyperemesis gravidarum (HEG). Methods: In this cross-sectional study, we compared ... -
The sperm parameters and prediction of IUI success
Güney, Gürhan (Turgut Ozal Medical Center, 2020)Aim: We aimed to compare the different sperm motility parameters in pregnant and non-pregnant patients who underwent IUI in our tertiary center. Material and Methods: Total of 110 gonadotrophin plus IUI patients were ...
