Browsing by Author "Genç, Hayriye"
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Impact of carbazole p-lactam derivatives on paraoxonase-1 activity
Gökçe, Başak; Bytyqi-Damoni, Arlinda; Genç, Hayriye; Zengin, Mustafa; Gencer, Nahit; Arslan, Oktay (Parlar Scientific Publications, 2017)Paraoxonase 1 (PON1) is an antioxidant enzyme associated with high-density lipoproteins (HDL). PON1 has the ability to inhibit lipid peroxides and to hydrolyze a wide variety of substrates such as esters, thioesters, ... -
In vitro effect of novel beta-lactam compounds on xanthine oxidase enzyme activity
Bytyqi-Damoni, Arlinda; Genç, Hayriye; Bytyqi-Damoni, Arlinda; Zengin, Mustafa; Beyaztaş, Serap; Gençer, Nahit; Arslan, Oktay (Informa Healthcare, 2012)Carbazole substituted imines (2a-I) were prepared from N-methyl-3-amino carbazole with different aldehydes. The imines compounds undergo (2 + 2) cycloaddition reactions with in situ ketenes to produce beta-lactam compounds ... -
In vitro inhibition of polyphenol oxidase by some new diarylureas
Demir, Dudu; Gençer, Nahit; Arslan, Oktay; Genç, Hayriye; Zengin, Mustafa (Informa Healthcare, 2012)A new series of N,N'-diarylureas (1-9) was synthesized. These compounds were investigated as inhibitors of polyphenol oxidase (PPO) which had been purified from banana by an affinity gel comprised of Sepharose 4B-L-tyros ... -
Novel β-lactam compounds as activators for polyphenoloxidase
Bytyqi-Damoni, Arlinda; Genç, Hayriye; Zengin, Mustafa; Demir, Dudu; Gencer, Nahit; Arslan, Oktay (Wiley V C H Verlag GMBH, 2020)A copper-containing enzyme polyphenol oxidase (other name is tyrosinase) plays crucial role in melanin biosynthesis, as a compound responsible for human pigmentation. Non controlled loss of melanin can cause hypopigmentation ... -
Synthesis and biological evaluation of new 4-thiazolidinone derivatives as carbonic anhydrase inhibitors
Genç, Hayriye; Çeken, Büşra; Bilen, Çiğdem; Saçkes, Zübeyde; Gencer, Nahit; Arslan, Oktay (Bentham Science Publ Ltd, 2017)Background: The catalytically active site of CA enzyme is Zn (II) bound hydroxide ion part which acts as a strong nucleophile (at neutral pH) on the CO2 molecule bound in a hydrophobic pocket nearby. We designed a series ... -
Synthesis and tyrosinase inhibitory properties of novel isoquinoline urea/thiourea derivatives
Genç, Hayriye; Zengin, Mustafa; Yavuz, Emre; Arslan, Oktay; Gençer, Nahit (Informa Healthcare, 2014)A new series of isoquinoline urea/thiourea derivatives (1-11) were synthesized, and their inhibitory effects on tyrosinase were evaluated. Isoquinoline urea/thiourea derivatives were obtained as a result of the reaction ... -
Synthesis, biological activity and structure-activity relationship of novel diphenylurea derivatives containing tetrahydroquinoline as carbonic anhydrase I and II inhibitors
Atahan, Alparslan; Gencer, Nahit; Bilen, Çiğdem; Yavuz, Emre; Genç, Hayriye; Sönmez, Fatih; Zengin, Mustafa; Ceylan, Mustafa (Wiley-V C H Verlag GMBH, 2018)A series of novel tetrahydroquinoline derivatives containing urea moiety was synthesized and their invitro inhibitory effects on the human carbonic anhydrase isoenzymes (hCA-I and hCA-II) were evaluated by using the CO2 ...
