Browsing by Author "Işık, Semra"
Now showing items 1-20 of 31
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7-amino-3,4-dihydro-1h-quinolin-2-one, a compound similar to the substituted coumarins, inhibits alpha-carbonic anhydrases without hydrolysis of the lactam ring
Vullo, Daniela; Işık, Semra; Bozdağ, Murat; Carta, Fabrizio; Supuran, Claudiu T. (Taylor & Francis Ltd, 2015)7-Amino-3,4-dihydro-1H-quinolin-2-one, a compound structurally similar to coumarins, recently discovered class of inhibitors of the alpha-carbonic anhydrases (CAs, EC 4.2.1.1) was investigated for its interaction with all ... -
Anion inhibition studies of the α-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae
Vullo, Daniela; Işık, Semra; Del Prete, Sonia; De Luca, Viviana; Carginale, Vincenzo; Scozzafava, Andrea; Supuran, Claudiu; Capasso, Clemente (Pergamon - Elsevier Ltd, 2013)An alpha-carbonic anhydrase (CA, EC 4.2.1.1) has been recently cloned and characterized in the human pathogenic bacterium Vibrio cholerae, denominated VchCA (Del Prete et al. J. Med. Chem. 2012, 55, 10742). This enzyme ... -
Carbonic anhydrase activators: Activation of the β-carbonic anhydrase Nce103 from the yeast Saccharomyces cerevisiae with amines and amino acids
Işık, Semra; Köçkar, Feray; Aydın, Meltem; Arslan, Oktay; Güler, Özen Özensoy; Innocenti, Alessio; Scozzafava, Andrea; Supuran, Claudiu T. (Pergamon-Elsevier Science Ltd, 2009)The protein encoded by the Nce103 gene of Saccharomyces cerevisiae, a beta-carbonic anhydrase (CA, EC 4.2.1.1) designated as scCA, was investigated for its activation with amines and amino acids. scCA was poorly activated ... -
Carbonic anhydrase from Cyprinus carpio
Özensoy, Özen; Arslan, Oktay; Işık, Semra (Elsevier GMBH, 2003)Carbonic anhydrase (CA) is the basic enzyme in the breathing function and catalyses the reversible hydration of CO2 to HCO3- and H+.A method is introduced to purify the carbonic anhydrase from erythrocytes of the carp ... -
Carbonic anhydrase inhibitors. Inhibition of red blood cell ostrich (Struthio camelus) carbonic anhydrase with a series of aromatic and heterocyclic sulfonamides
Özensoy, Özen; Arslan, Oktay; Işık, Semra; Arslan, Mikail; Scozzafava, Andrea; Supuran, Claudiu T. (Taylor & Francis Ltd, 2005)The purification of red blood cell carbonic anhydrase (CA, EC 4.2. 1. 1) from ostrich (scCA) blood is reported, as well as an inhibition study of this enzyme with a series of aromatic and heterocylic sulfonamides. The ... -
Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with anions
Işık, Semra; Köçkar, Feray; Arslan, Oktay; Güler, Özen Özensoy; Innocenti, Alessio; Supuran, Claudiu T. (Pergamon-Elsevier Science Ltd, 2008)The protein encoded by the Nce103 gene of Saccharomyces cerevisiae, a beta-carbonic anhydrase (CA, EC 4.2.1.1) designated as scCA, has been cloned, purified, characterized kinetically, and investigated for its inhibition ... -
Carbonic anhydrase inhibitors: Inhibition of the β-class enzyme from the yeast Saccharomyces cerevisiae with sulfonamides and sulfamates
Işık, Semra; Köçkar, Feray; Aydın, Meltem; Arslan, Oktay; Güler, Özen Özensoy; Innocenti, Alessio; Scozzafava, Andrea; Supuran, Claudiu T. (Pergamon-Elsevier Science Ltd, 2009)The protein encoded by the Nce103 gene of Saccharomyces cerevisiae, a beta-carbonic anhydrase ( CA, EC 4.2.1.1) designated as scCA, has been cloned, purified, characterized kinetically and investigated for its inhibition ... -
Cloning, characterization and anion inhibition study of a beta-class carbonic anhydrase from the caries producing pathogen streptococcus mutans
Dedeoğlu, Nurcan; De Luca, Viviana; Işık, Semra; Yıldırım, Hatice; Köçkar, Feray; Capasso, Clemente; Supuran, Claudiu T. (Pergamon-Elsevier Science Ltd, 2015)The oral pathogenic bacterium involved in human dental caries formation Streptococcus mutans, encodes for two carbonic anhydrase (CA, EC 4.2.1.1) one belonging to the alpha- and the other one to the beta-class. This last ... -
Corrigendum to "An evaluation of cytosolic erythrocyte carbonic anhydrase and catalase in carcinoma patients: An elevation of carbonic anhydrase activity" [Clin. Biochem. 39 (2006) 804-809] (DOI:10.1016/j.clinbiochem.2006.03.001)
Özensoy, Özen; Köçkar, Feray Tura; Arslan, Oktay; Işık, Semra; Supuran, Claudiu T.; Lyon, Malcolm (2007)ÖZET YOK -
Corrigendum to “An evaluation of cytosolic erythrocytecarbonic anhydrase and catalase in carcinoma patients:An elevation of carbonic anhydrase activity” [Clin. Biochem. 39 (2006) 804–809]
Özensoy, Özen; Köçkar, Feray; Arslan, Oktay; Işık, Semra; Supuran, Claudlu T.; Lyon, Malcolm (Pergamon-Elsevier Science Ltd, 2007)No Abstract -
Değişik balık türlerinden elde edilen karbonik anhidraz enzimi üzerine bazı pestisitlerin etkilerinin araştırılması
Işık, Semra (Balıkesir Üniversitesi Fen Bilimleri Enstitüsü, 2002)Bu çalışmanın birinci bölümünde beş farklı tür balık(Cyprinus carpio, Barbus barbus, Salmo gairdnerü, Diplodus vulgaris ve Scorpaena porcus ) eritrositlerinden elde edilen karbonik anhidraz enzimi üzerine bazı pestisitlerin ... -
DNA cloning, characterization, and inhibition studies of an alpha-carbonic anhydrase from the pathogenic bacterium vibrio cholerae
Del Prete, Sonia; Işık, Semra; Vullo, Daniela; De Luca, Viviana; Carginale, Vincenzo; Scozzafava, Andrea; Supuran, Claudiu T.; Capasso, Clemente (Amer Chemical Soc, 2012)We have cloned, purified, and characterized an alpha-carbonic anhydrase (CA, EC 4.2.1.1) from the human pathogenic bacterium Vibrio cholerae, VchCA. The new enzyme has significant catalytic activity, and an inhibition study ... -
Effect of antithrombotic therapy on development of acute subdural hematoma after burr hole drainage of chronic subdural hematoma
Yüksel, Mehmet Onur; Çevik, Serdar; Erdogan, Barış; Tunçkale, Tamer; Katar, Salim; Işık, Semra; Çalışkan, Tezcan; Evran, Şevket (Turkish Neurosurgical Soc, 2020)AIM: To evaluate the relationship between the time from cessation of anticoagulant/antiplatelet medication to surgery and risk of postoperative acute subdural hematoma (ASDH) after burr hole drainage of chronic subdural ... -
An evaluation of cytosolic erythrocyte carbonic anhydrase and catalase in carcinoma patients: An elevation of carbonic anhydrase activity
Özensoy, Özen; Köçkar, Feray; Arslan, Oktay; Işık, Semra; Supuran, Claudiu T.; Lyon, Malcolm (Pergamon-Elsevier Science Ltd, 2006)Objectives: The antioxidant enzyme catalase and the CO2/HCO3- exchange enzyme carbonic anhydrase are both present in significant amounts in the cytosol of erythrocytes. The aim of the present study was to investigate whether ... -
Farklı koyun ırklarından karbonik anhidraz enziminin saflaştırılması ve bazı pestisitlerin enzim üzerine etkilerinin araştırılması
Yalçın, Yıldız (Balıkesir Üniversitesi Fen Bilimleri Enstitüsü, 2022)Bu çalışmada, canlıların yapısında son derece önemli fizyolojik role sahip karbonik anhidraz (CA, E.C.4.2.1.1) enziminin Dorset Down, Merinos, Kıvırcık koyun kan eritrositlerinden saflaştırılmıştır ve bazı pestisitlerin ... -
In vitro inhibition effect and structure-activity relationships of some saccharin derivatives on erythrocyte carbonic anhydrase I and II
Sönmez, Fatih; Bilen, Çiğdem; Sümersan, Sinem; Gençer, Nahit; Işık, Semra; Arslan, Oktay; Küçükislamoğlu, Mustafa (Taylor & Francis Ltd, 2014)In this study, in vitro inhibitory effects of some saccharin derivatives on purified carbonic anhydrase I and II were investigated using CO2 as a substrate. The results showed that all compounds inhibited the hCA I and hCA ... -
Interaction of carbonic anhydrase isozymes I, II, and IX with some pyridine and phenol hydrazinecarbothioamide derivatives
Işık, Semra; Vullo, Daniela; Durdağı, Serdar; Ekinci, Deniz; Şentürk, Murat; Çetin, Ahmet; Şentürk, Esra; Supuran, Claudiu T. (Pergamon-Elsevier Science Ltd, 2015)A series of hydrazinecarbothioamide derivatives incorporating ethyl, phenyl, tolyl, benzyl, and allyl moieties were prepared and tested as possible inhibitors of three members of the pH regulatory enzyme family, carbonic ... -
Karbonik anhidraz izoenzimlerinin saflaştırılması için yeni bir afinite jelinin sentezlenmesi
Ökemler, Gamze (Balıkesir Üniversitesi Fen Bilimleri Enstitüsü, 2016)Bu çalışmada, tüm canlılarda bulunan ve solunum sisteminin önemli enzimlerinden biri olan karbonik anhidraz enzimi insan eritrositlerinden saflaştırılmıştır. Proteinlerin saflaştırılmasında en kolay ve kullanışlı bir teknik ... -
Kinetic and docking studies of cytosolic/tumor-associated carbonic anhydrase isozymes I, II and IX with some hydroxylic compounds
Durdağı, Serdar; Korkmaz, Neslihan; Işık, Semra; Vullo, Daniela; Astley, Demet; Ekinci, Deniz; Salmas, Ramin E.; Şentürk, Murat; Supuran, Claudiu T. (Taylor & Francis Inc, 2016)A series of hydroxylic compounds (1-10, NK-154 and NK-168) have been assayed for the inhibition of three physiologically relevant carbonic anhydrase isozymes, the cytosolic isozymes I, II and tumor-associated isozyme IX. ... -
Koyun serum paraoksonaz enziminin bazı pestisitlere karşı ilgisinin araştırılması
Şipal, Beste (Balıkesir Üniversitesi Fen Bilimleri Enstitüsü, 2011)Bu çalışmada, detoksifikasyon ve antioksidan aktivitesi ile metabolizmada önemli fizyolojik fonksiyona sahip paraoksonaz (PON) enzimi Merinos ve Kıvırcık koyunu kan serumlarından saflaştırılmıştır. Saflaştırmada ...
