Browsing by Author "Karataş, Mert Olgun"
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Coumarin or benzoxazinone based novel carbonic anhydrase inhibitors: synthesis, molecular docking and anticonvulsant studies
Karataş, Mert Olgun; Uslu, Harun; Sarı, Suat; Alagöz, Mehmet Abdullah; Karakurt, Arzu; Alıcı, Bülent; Bilen, Çiğdem; Yavuz, Emre (Taylor & Francis Inc, 2016)Among many others, coumarin derivatives are known to show human carbonic anhydrase (hCA) inhibitory activity. Since hCA inhibition is one of the underlying mechanisms that account for the activities of some antiepileptic ... -
Functionalized imidazolium and benzimidazolium salts as paraoxonase 1 inhibitors: Synthesis, characterization and molecular docking studies
Karataş, Mert Olgun; Uslu, Harun; Alıcı, Bülent; Gökçe, Başak; Gencer, Nahit; Arslan, Oktay; Arslan, N. Burcu; Özdemir, Namık (Pergamon-Elsevier Science Ltd, 2016)Paraoxonase (PON) is a key enzyme in metabolism of living organisms and decreased activity of PON1 was acknowledged as a risk for atherosclerosis and organophosphate toxicity. The present study describes the synthesis, ... -
Hidroksi kumarin kuaterner amonyum tuzlarının sentezi ve karakterizasyonu
Karataş, Mert Olgun (Balıkesir Üniversitesi Fen Bilimleri Enstitüsü, 2011)Kumarin ( 2H-1-benzopiran-2-on ) bileşikleri birçok bitki hücresinde bulunmakta ve laboratuar ortamında sentezlenmektedir. Kumarin bileşikleri son yıllarda özellikle biyolojik aktivitelerinden dolayı ilgi ile çalışılmaktadır. ... -
In vitro inhibition effect of some coumarin compounds on purified human serum paraoxonase 1 (PON1)
Gökce, Başak; Gencer, Nahit; Arslan, Oktay; Karataş, Mert Olgun; Alıcı, Bülent (Taylor & Francis Inc, 2016)Human serum paraoxonase 1 (PON1; EC 3.1.8.1) is a high-density lipoprotein associated, calcium-dependent enzyme that hydrolyses aromatic esters, organophosphates and lactones and can protect the low-density lipoprotein ... -
Inhibition of paraoxonase 1 by coumarin-substituted N-heterocyclic carbene silver(I), ruthenium(II) and palladium(II) complexes
Karataş, Mert Olgun; Çalgın, Gamze; Alıcı, Bülent; Gökçe, Başak; Gençer, Nahit; Tok, Tuğba Taşkın; Arslan, Oktay; Kılıç-Cıkla, Işın (Wiley, 2019)We synthesized three coumarin-substituted benzimidazolium chlorides and their silver(I), ruthenium(II) and palladium(II) N-heterocyclic carbene (NHC) complexes. All compounds were characterized using appropriate spectroscopic ... -
New coumarin derivatives as carbonic anhydrase inhibitors
Karataş, Mert Olgun; Alıcı, Bülent; Çakır, Ümit; Çetinkaya, Engin; Demir, Dudu; Ergün, Adem; Gençer, Nahit; Arslan, Oktay (Taylor & Francis Ltd, 2014)In the current study, a series of 4-chloromethyl-7-hydroxy-coumarin derivatives containing imidazolium, benzimidazolium, bisbenzimidazolium and quaternary ammonium salts were synthesized, characterized and the inhibition ... -
Some coumarins and benzoxazinones as potent paraoxonase 1 inhibitors
Karataş, Mert Olgun; Uslu, Harun; Alıcı, Bülent; Gökçe, Başak; Gençer, Nahit; Arslan, Oktay (Taylor & Francis Inc, 2016)In this study, we aimed to investigate the effect of some coumarin and benzoxazinone derivatives on the activity of human PON1. Human serum paraoxonase 1 was purified from fresh human serum blood by two-step procedures ... -
Synthesis and carbonic anhydrase inhibitory properties of novel coumarin derivatives
Karataş, Mert Olgun; Alıcı, Bülent; Çakır, Ümit; Çetinkaya, Engin; Demir, Dudu; Ergün, Adem; Gençer, Nahit; Arslan, Oktay (Informa Healthcare, 2013)A newly series of water-soluble 1-alkyl-3-(4-methyl-7, 8-dihydroxy-2H-chromen-2-one) benzimidazolium chloride salts (3a-j) were synthesized and their inhibitory effects on the activity of purified human carbonic anhydrase ... -
Synthesis, characterization and tyrosinase inhibitory properties of benzimidazole derivatives
Karataş, Mert Olgun; Alıcı, Bülent; Çetinkaya, Engin; Bilen, Çiğdem; Gencer, Nahit; Arslan, Oktay (Maik Nauka/İnterperiodica/Springer, 2014)1-Alkylbenzimidazole and 1,3-dialkyl benzimidazolium salts were synthesized and characterized by the data of IR, H-1 NMR, C-13 NMR spectra and elemental analyses. These compounds were investigated as tyrosinase inhibitors. ... -
Water soluble coumarin quaternary ammonium chlorides: synthesis and biological evaluation
Karataş, Mert Olgun; Noma, Samir Abbas Ali; Gürses, Canbolat; Balcıoğlu, Sevgi; Ateş, Burhan; Alıcı, Bülent; Çakır, Ümit (Wiley V C H Verlag GMBH, 2020)In the present study, coumarin-bearing three pyridinium and three tetra-alkyl ammonium salts were synthesized. The compounds were fully characterized by(1)H- and(13)C-NMR, LC/MS and IR spectroscopic methods and elemental ...
