Browsing by Author "Supuran, Claudiu T."
Now showing items 1-20 of 24
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4-Functionalized 1,3-diarylpyrazoles bearing benzenesulfonamide moiety as selective potent inhibitors of the tumor associated carbonic anhydrase isoforms IX and XII
Khloya, Poonam; Çelik, Gülşah; SitaRam; Vullo, Daniela; Supuran, Claudiu T.; Sharma, Pawan K. (Elsevier France-Editions Scientifiques Medicales Elsevie, 2014)A library of 4-functionalized 1,3-diarylpyrazoles (3a-3h, 5a-5g and 6a-6g) was designed, synthesized and evaluated against four human carbonic anhydrase (CA, EC 4.2.1.1) isozymes representing two cytosolic isozymes hCA I ... -
7-amino-3,4-dihydro-1h-quinolin-2-one, a compound similar to the substituted coumarins, inhibits alpha-carbonic anhydrases without hydrolysis of the lactam ring
Vullo, Daniela; Işık, Semra; Bozdağ, Murat; Carta, Fabrizio; Supuran, Claudiu T. (Taylor & Francis Ltd, 2015)7-Amino-3,4-dihydro-1H-quinolin-2-one, a compound structurally similar to coumarins, recently discovered class of inhibitors of the alpha-carbonic anhydrases (CAs, EC 4.2.1.1) was investigated for its interaction with all ... -
Benzenesulfonamide bearing 1,2,4-triazole scaffolds as potent inhibitors of tumor associated carbonic anhydrase isoforms hCA IX and hCA XII
SitaRam; Çelik, Gülşah; Khloya, Poonam; Vullo, Daniela; Supuran, Claudiu T.; Sharma, Pawan K. (Pergamon-Elsevier Science Ltd, 2014)Three series of novel heterocyclic compounds (3a-3g, 4a-4g and 5a-5g) containing benzenesulfonamide moiety and incorporating a 1,2,4-triazole ring, have been synthesized and investigated as inhibitors against four isomers ... -
Carbonic anhydrase activators: Activation of the β-carbonic anhydrase Nce103 from the yeast Saccharomyces cerevisiae with amines and amino acids
Işık, Semra; Köçkar, Feray; Aydın, Meltem; Arslan, Oktay; Güler, Özen Özensoy; Innocenti, Alessio; Scozzafava, Andrea; Supuran, Claudiu T. (Pergamon-Elsevier Science Ltd, 2009)The protein encoded by the Nce103 gene of Saccharomyces cerevisiae, a beta-carbonic anhydrase (CA, EC 4.2.1.1) designated as scCA, was investigated for its activation with amines and amino acids. scCA was poorly activated ... -
Carbonic anhydrase inhibitors. Inhibition of red blood cell ostrich (Struthio camelus) carbonic anhydrase with a series of aromatic and heterocyclic sulfonamides
Özensoy, Özen; Arslan, Oktay; Işık, Semra; Arslan, Mikail; Scozzafava, Andrea; Supuran, Claudiu T. (Taylor & Francis Ltd, 2005)The purification of red blood cell carbonic anhydrase (CA, EC 4.2. 1. 1) from ostrich (scCA) blood is reported, as well as an inhibition study of this enzyme with a series of aromatic and heterocylic sulfonamides. The ... -
Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with anions
Işık, Semra; Köçkar, Feray; Arslan, Oktay; Güler, Özen Özensoy; Innocenti, Alessio; Supuran, Claudiu T. (Pergamon-Elsevier Science Ltd, 2008)The protein encoded by the Nce103 gene of Saccharomyces cerevisiae, a beta-carbonic anhydrase (CA, EC 4.2.1.1) designated as scCA, has been cloned, purified, characterized kinetically, and investigated for its inhibition ... -
Carbonic anhydrase inhibitors: Inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides
Özensoy, Özen; Puccetti, Luca; Fasolis, Giuseppe; Arslan, Oktay; Scozzafava, Andrea; Supuran, Claudiu T. (Pergamon-Elsevier Science Ltd, 2005)The inhibition of the two transmembrane, tumor-associated isozymes of carbonic anhydrase (CA, EC 4.2.1.1) of human origin, hCA IX and XII, with a library of aromatic and heteroaromatic sulfonamides has been investigated. ... -
Carbonic anhydrase inhibitors: Inhibition of the β-class enzyme from the yeast Saccharomyces cerevisiae with sulfonamides and sulfamates
Işık, Semra; Köçkar, Feray; Aydın, Meltem; Arslan, Oktay; Güler, Özen Özensoy; Innocenti, Alessio; Scozzafava, Andrea; Supuran, Claudiu T. (Pergamon-Elsevier Science Ltd, 2009)The protein encoded by the Nce103 gene of Saccharomyces cerevisiae, a beta-carbonic anhydrase ( CA, EC 4.2.1.1) designated as scCA, has been cloned, purified, characterized kinetically and investigated for its inhibition ... -
Carbonic anhydrase inhibitors: purification and inhibition studies of pigeon (Columba livia var. domestica) red blood cell carbonic anhydrase with sulfonamides
Özensoy, Özen; Arslan, Mikail; Supuran, Claudiu T. (Informa Healthcare, 2011)A carbonic anhydrase (CA, EC 4.2.1.1) from red blood cells of pigeons (Columba livia var. domestica), clCA, was purified to homogeneity. Its kinetic parameters for the CO(2) hydration reaction were measured. With a k(cat)/K(m) ... -
Carbonic anhydrase IX as prognostic marker for tumor progression and as a target for novel antitumor drugs
Özensoy, Özen; Supuran, Claudiu T. (2007)Metaloenzim karbonik anhidrazın [CA, EC 4.2.1.1] izoenzimi IX -CA IX- hipokside yüksek düzeyde ifade edilen genlerden birisidir. CA IX özellikle hipoksik tümör dokularında bulunup gastrointestinal yoldaki düşük düzeydeki ... -
Carbonic anhydrase IX as prognostic marker for tumor progression and as a target for novel antitumor drugs
Özensoy, Özen; Supuran, Claudiu T. (Turkish Biochem Soc, 2007)One of the genes highly upregulated by hypoxia is that encoding isozyme IX of the metalloenzyme carbonic anhydrase [ CA, EC 4.2.1.1], CA IX. CA IX is a high activity tumor- associated membrane enzyme predominantly found ... -
Cloning, characterization and anion inhibition study of a beta-class carbonic anhydrase from the caries producing pathogen streptococcus mutans
Dedeoğlu, Nurcan; De Luca, Viviana; Işık, Semra; Yıldırım, Hatice; Köçkar, Feray; Capasso, Clemente; Supuran, Claudiu T. (Pergamon-Elsevier Science Ltd, 2015)The oral pathogenic bacterium involved in human dental caries formation Streptococcus mutans, encodes for two carbonic anhydrase (CA, EC 4.2.1.1) one belonging to the alpha- and the other one to the beta-class. This last ... -
Corrigendum to "An evaluation of cytosolic erythrocyte carbonic anhydrase and catalase in carcinoma patients: An elevation of carbonic anhydrase activity" [Clin. Biochem. 39 (2006) 804-809] (DOI:10.1016/j.clinbiochem.2006.03.001)
Özensoy, Özen; Köçkar, Feray Tura; Arslan, Oktay; Işık, Semra; Supuran, Claudiu T.; Lyon, Malcolm (2007)ÖZET YOK -
DNA cloning, characterization, and inhibition studies of an alpha-carbonic anhydrase from the pathogenic bacterium vibrio cholerae
Del Prete, Sonia; Işık, Semra; Vullo, Daniela; De Luca, Viviana; Carginale, Vincenzo; Scozzafava, Andrea; Supuran, Claudiu T.; Capasso, Clemente (Amer Chemical Soc, 2012)We have cloned, purified, and characterized an alpha-carbonic anhydrase (CA, EC 4.2.1.1) from the human pathogenic bacterium Vibrio cholerae, VchCA. The new enzyme has significant catalytic activity, and an inhibition study ... -
Drug design studies of the novel antitumor targets carbonic anhydrase IX and XII
Güler, Özen Özensoy; De Simone, Giovanni; Supuran, Claudiu T. (Bentham Science Publ Ltd, 2010)The carbonic anhydrase (CA, EC 4.2.1.1) isozymes IX and XII are predominantly found in tumor cells and show a restricted expression in normal tissues. By efficiently hydrating carbon dioxide to protons and bicarbonate, ... -
An evaluation of cytosolic erythrocyte carbonic anhydrase and catalase in carcinoma patients: An elevation of carbonic anhydrase activity
Özensoy, Özen; Köçkar, Feray; Arslan, Oktay; Işık, Semra; Supuran, Claudiu T.; Lyon, Malcolm (Pergamon-Elsevier Science Ltd, 2006)Objectives: The antioxidant enzyme catalase and the CO2/HCO3- exchange enzyme carbonic anhydrase are both present in significant amounts in the cytosol of erythrocytes. The aim of the present study was to investigate whether ... -
Interaction of carbonic anhydrase isozymes I, II, and IX with some pyridine and phenol hydrazinecarbothioamide derivatives
Işık, Semra; Vullo, Daniela; Durdağı, Serdar; Ekinci, Deniz; Şentürk, Murat; Çetin, Ahmet; Şentürk, Esra; Supuran, Claudiu T. (Pergamon-Elsevier Science Ltd, 2015)A series of hydrazinecarbothioamide derivatives incorporating ethyl, phenyl, tolyl, benzyl, and allyl moieties were prepared and tested as possible inhibitors of three members of the pH regulatory enzyme family, carbonic ... -
Kinetic and docking studies of cytosolic/tumor-associated carbonic anhydrase isozymes I, II and IX with some hydroxylic compounds
Durdağı, Serdar; Korkmaz, Neslihan; Işık, Semra; Vullo, Daniela; Astley, Demet; Ekinci, Deniz; Salmas, Ramin E.; Şentürk, Murat; Supuran, Claudiu T. (Taylor & Francis Inc, 2016)A series of hydroxylic compounds (1-10, NK-154 and NK-168) have been assayed for the inhibition of three physiologically relevant carbonic anhydrase isozymes, the cytosolic isozymes I, II and tumor-associated isozyme IX. ... -
A new affinity gel for the purification of alpha-carbonic anhdrases
Şahin, Ayşegül; Işık, Semra; Arslan, Oktay; Supuran, Claudiu T.; Güler, Özen Özensoy (Taylor & Francis Ltd, 2015)The new affinity gel reported in this study was prepared using EUPERGIT C250L as a chromatographic bed material, to which etylenediamine spacer arms were attached to prevent steric hindrance between the matrix and ligand, ... -
Privileged scaffolds in medicinal chemistry: Studies on pyrazolo[1,5-a]pyrimidines on sulfonamide containing Carbonic Anhydrase inhibitors
Gümüş, Arzu; Bozdağ, Murat; Angeli, Andrea; Peat, Thomas S.; Carta, Fabrizio; Supuran, Claudiu T.; Selleri, Silvia (Pergamon-Elsevier Science Ltd, 2021)We report for the first time a small series of compounds endowed in vitro with inhibitory properties for the human (h) expressed Carbonic Anhydrase (CAs, E.C. 4.2.1.1) enzymes of physiological interest (i.e. I, II, VA, IX ...
