Browsing by Author "Vullo, Daniela"
Now showing items 1-8 of 8
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4-Functionalized 1,3-diarylpyrazoles bearing benzenesulfonamide moiety as selective potent inhibitors of the tumor associated carbonic anhydrase isoforms IX and XII
Khloya, Poonam; Çelik, Gülşah; SitaRam; Vullo, Daniela; Supuran, Claudiu T.; Sharma, Pawan K. (Elsevier France-Editions Scientifiques Medicales Elsevie, 2014)A library of 4-functionalized 1,3-diarylpyrazoles (3a-3h, 5a-5g and 6a-6g) was designed, synthesized and evaluated against four human carbonic anhydrase (CA, EC 4.2.1.1) isozymes representing two cytosolic isozymes hCA I ... -
7-amino-3,4-dihydro-1h-quinolin-2-one, a compound similar to the substituted coumarins, inhibits alpha-carbonic anhydrases without hydrolysis of the lactam ring
Vullo, Daniela; Işık, Semra; Bozdağ, Murat; Carta, Fabrizio; Supuran, Claudiu T. (Taylor & Francis Ltd, 2015)7-Amino-3,4-dihydro-1H-quinolin-2-one, a compound structurally similar to coumarins, recently discovered class of inhibitors of the alpha-carbonic anhydrases (CAs, EC 4.2.1.1) was investigated for its interaction with all ... -
Anion inhibition studies of the α-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae
Vullo, Daniela; Işık, Semra; Del Prete, Sonia; De Luca, Viviana; Carginale, Vincenzo; Scozzafava, Andrea; Supuran, Claudiu; Capasso, Clemente (Pergamon - Elsevier Ltd, 2013)An alpha-carbonic anhydrase (CA, EC 4.2.1.1) has been recently cloned and characterized in the human pathogenic bacterium Vibrio cholerae, denominated VchCA (Del Prete et al. J. Med. Chem. 2012, 55, 10742). This enzyme ... -
Benzenesulfonamide bearing 1,2,4-triazole scaffolds as potent inhibitors of tumor associated carbonic anhydrase isoforms hCA IX and hCA XII
SitaRam; Çelik, Gülşah; Khloya, Poonam; Vullo, Daniela; Supuran, Claudiu T.; Sharma, Pawan K. (Pergamon-Elsevier Science Ltd, 2014)Three series of novel heterocyclic compounds (3a-3g, 4a-4g and 5a-5g) containing benzenesulfonamide moiety and incorporating a 1,2,4-triazole ring, have been synthesized and investigated as inhibitors against four isomers ... -
DNA cloning, characterization, and inhibition studies of an alpha-carbonic anhydrase from the pathogenic bacterium vibrio cholerae
Del Prete, Sonia; Işık, Semra; Vullo, Daniela; De Luca, Viviana; Carginale, Vincenzo; Scozzafava, Andrea; Supuran, Claudiu T.; Capasso, Clemente (Amer Chemical Soc, 2012)We have cloned, purified, and characterized an alpha-carbonic anhydrase (CA, EC 4.2.1.1) from the human pathogenic bacterium Vibrio cholerae, VchCA. The new enzyme has significant catalytic activity, and an inhibition study ... -
Interaction of carbonic anhydrase isozymes I, II, and IX with some pyridine and phenol hydrazinecarbothioamide derivatives
Işık, Semra; Vullo, Daniela; Durdağı, Serdar; Ekinci, Deniz; Şentürk, Murat; Çetin, Ahmet; Şentürk, Esra; Supuran, Claudiu T. (Pergamon-Elsevier Science Ltd, 2015)A series of hydrazinecarbothioamide derivatives incorporating ethyl, phenyl, tolyl, benzyl, and allyl moieties were prepared and tested as possible inhibitors of three members of the pH regulatory enzyme family, carbonic ... -
Kinetic and docking studies of cytosolic/tumor-associated carbonic anhydrase isozymes I, II and IX with some hydroxylic compounds
Durdağı, Serdar; Korkmaz, Neslihan; Işık, Semra; Vullo, Daniela; Astley, Demet; Ekinci, Deniz; Salmas, Ramin E.; Şentürk, Murat; Supuran, Claudiu T. (Taylor & Francis Inc, 2016)A series of hydroxylic compounds (1-10, NK-154 and NK-168) have been assayed for the inhibition of three physiologically relevant carbonic anhydrase isozymes, the cytosolic isozymes I, II and tumor-associated isozyme IX. ... -
O-Benzenedisulfonimido-sulfonamides are potent inhibitors of the tumor-associated carbonic anhydrase isoforms CA IX and CA XII
Akdemir, Özlen Güzel; Akdemir, Atilla; Işık, Semra; Vullo, Daniela; Supuran, Claudiu (Pergamon - Elsevier Ltd, 2013)By using phthalimido-substituted aromatic sufonamides as lead molecules, a series of new sulfonamides incorporating ortho-benzenedisulfonimide moieties have been synthesized and tested against the human (h) cytosolic ...
