Now showing items 1-10 of 12
The determination of effect of some antibiotics on paraoxonase 2 (PON2) enzyme activities in human macrophages cell
The human paraoxonase (hPON) gene family includes threemembers: PON1, PON2, and PON3, located adjacent to eachother on the long arm of chromosome 7. The three hPONs shareapproximately 65% identity at the amino acid level ...
Site-directed mutagenesis of Asn67/IIe67 in human CAII and expression of mutant protein in E-coli
(Blackwell Publishing, 2006)
Comparison of hydratase, esterase activities and inhibition manner of mutant Asn67/Ile and Leu204/Ser of human CAII
(Blackwell Publishing, 2008)
Carbonic anhydrases (CAs; also known as carbonate dehydratases EC 184.108.40.206) are a family of enzymes which catalyze the reversible reaction from H2O and CO2 to HCO3 - ions. Carbonic anhydrases are ubiquitous metalloenzymes ...
Antidepressant and antipsychotic drugs differentially affect pon1 enzyme activity
(Taylor & Francis Ltd, 2015)
Human serum paraoxonase (PON1, EC 220.127.116.11.) is a high-density lipid (HDL)-associated, calcium-dependent enzyme. In this study, the effects of Haloperidol, Fluoxetine hydrochloride, Diazepam and Acepromazine drugs used for ...
Effects of some antibiotics on paraoxonase from human serum in vitro and from mouse serum and liver in vivo
(Pharmaceutical Soc Japan, 2006)
Paraoxonase (PON1, EC 18.104.22.168) is an esterase protein which plays multifunctional role in metabolism. Therefore, in this study the effects of commonly used antibiotics, namely sodium ampicillin, ciprofloxacin, rifamycin ...
Mutation of active site residues Asn67 to Ile, Gln92 to Val and Leu204 to Ser in human carbonic anhydrase ii: influences on the catalytic activity and affinity for inhibitors
(Pergamon-Elsevier Science Ltd, 2012)
Site-directed mutagenesis has been used to change three amino acid residues involved in the binding of inhibitors (Asn67Ile; Gln92Val and Leu204Ser) within the active site of human carbonic anhydrase (CA, EC 22.214.171.124) II ...
Novel purification strategy for human PON1 and inhibition of the activity by cephalosporin and aminoglikozide derived antibiotics
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2006)
Human serum paraoxonase (PON1, EC 126.96.36.199.) is a high-density lipid (HDL)-associated, calcium-dependent enzyme; its physiological substrates are not known. In this study, a new purification strategy for human PON1 enzyme ...
In vivo effects of curcumin on the paraoxonase, carbonic anhydrase, glucose-6-phosphate dehydrogenase and beta-glucosidase enzyme activities in dextran sulphate sodium-induced ulcerative colitis mice
(Taylor & Francis Ltd, 2016)
Increases in the risk of infections and malignancy due to immune suppressive therapies of inflammatory bowel diseases (IBDs) have led the researchers to focus on more nontoxic and acceptable natural products like curcumin. ...
In vivo effects of oral contraceptives on paraoxonase, catalase and carbonic anhydrase enzyme activities on mouse
(Pharmaceutical Soc Japan, 2007)
Many effects that oestrogens and progestrogens used in oral contraceptive (OC) have on enzyme physiology are of importance on homeostasis. This study was carried out in order to determine the in vivo effect of three oral ...
Mutation of phe91 to asn in human carbonic anhydrase ı unexpectedly enhanced both catalytic activity and affinity for sulfonamide inhibitors
(Pergamon-Elsevier Science Ltd, 2010)
Site-directed mutagenesis has been used to change one amino acid residue considered non essential (Phe91Asn) to catalysis in carbonic anhydrase (CA, EC 188.8.131.52) isozyme I (hCA I), but which is near the substrate binding ...