Now showing items 1-10 of 15
Is thymoquinone promising anticancer agent in hepatoma cell line?
The biological activity ofNigella sativaseeds is mainly attributedto its essential oil component which is pre-dominantly (30–48%)thymoquinone (TQ). Therapeutic effect of TQ was exhibited inmany diseases including inflammation, ...
TGF-Beta upregulates URG-4/URGCP gene expression in Hepatoma cells
URG-4/URGCP has been found to contribute importantly tomultistep carcinogenesis. Over-expression of URG4/URGCPaccelerated tumor development in nude mice and also induced insome cancer cell types such as hepatocellular ...
Expression analysis of URG4 (upregulated gene 4) in osteoblast-like cells, Saos-2 and MG63
URG4 is a novel gene firstly found in uninfected liver cells stimu-lated by HBxAg (Hepatitis B virus encoded X antigen) and HCC(Hepatocellular Carcinoma) cells. It is associated with cellgrowth, growth factor-independent ...
Characterisation of the human URG-4 (Up-Regulated Gene 4) gene promoter
In silico and expression analysis of urg-4/urgcp gene in different cancer cells
(Nobel Science and Research Center, 2015)
Upregulated gene 4 (URG-4/URGCP) located in chromosome 7 (7p13), was originally suggested as one of the HBxAg upregulated genes in hepatoma cells and implicated in tumorogenesis process in different cells. In this study ...
SP1 is a transcriptional regulator of URG-4/URGCP gene in hepatocytes
URG-4/URGCP gene was implicated as an oncogene that contributes hepatocarcinogenesis regulated by Hepatitis-B-virus-encoded X antigen. However, the mechanism of transcriptional regulation of this gene remains largely ...
Prodrugs for nitroreductase based cancer therapy-1: metabolite profile, cell cytotoxicity and molecular modeling ınteractions of nitro benzamides with ssap-ntrb
(Bentham Science Publ Ltd, 2018)
Background: Directed Enzyme Prodrug Therapy (DEPT) as an alternative method against conventional cancer treatments, in which the non-toxic prodrug is converted to highly cytotoxic derivative, has attracted an ample attentions ...
Identification of intracellular pathways through which TGF-beta 1 upregulates URG-4/URGCP gene expression in hepatoma cells
(Pergamon-Elsevier Science Ltd,, 2016)
Aims: Up-regulated gene 4 (URG-4/URGCP) was strongly expressed in Hepatitis B infected liver and correlated with HBxAG (Hepatitis B x Antigen) protein and found to promote hepatocellular cancer. Transforming growth factor ...
Prodrugs for nitroreductase based cancer therapy-2: Novel amide/Ntr combinations targeting PC3 cancer cells
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2019)
The use of nitroreductases (NTR) that catalyze the reduction of nitro compounds by using NAD(P)H in GDEPT (Gene-directed enzyme prodrug therapy) studies which minimize toxicity at healthy cells and increases concentration ...
Synthesis and biological evaluation of 2,4,6-trinitroaniline derivatives as potent antitumor agents
(Springer Wien, 2020)
Nitro group-containing compounds are well known as effective anticancer drugs. The aim of the study is to synthesize a series of trinitroaniline derivatives to determine their potential antitumor activities on diverse ...