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Evaluation of Azadirachtin on Arthrospira plantensis Gomont growth parameters and antioxidant enzymes
(EDP Sciences S A, 2020)
To understand the effects of contamination of insecticides onphototrophs, and to determine the responses of these organisms against these chemicals are extremely important in understanding how the ecosystem is affected. ...
Molecular cloning and biochemical characterization of a Tau class glutathione S-transferase from Pinus brutia Ten
(Springer Heidelberg, 2020)
Key message A new Tau class GST gene was cloned from Pinus brutia Ten. cDNA sequence was analysed for conserved sequences. Substrate specificity, optimum pH, and temperature values of the recombinant PbGST Tau enzyme were ...
Development and characterization of superparamagnetic nanomaterial to determine its potential application in removing the bitterness of table olives
(MYU, 2020)
The aim of this study is to develop stable superparamagnetic iron oxide nanoparticles (SPIONs) for the immobilization of beta-glucosidase. The goal is to figure out the possibility of applying immobilization techniques in ...
Synthesis and biological evaluation of 2,4,6-trinitroaniline derivatives as potent antitumor agents
(Springer Wien, 2020)
Nitro group-containing compounds are well known as effective anticancer drugs. The aim of the study is to synthesize a series of trinitroaniline derivatives to determine their potential antitumor activities on diverse ...
Cloning of the Ssap-NtrB prokaryotic gene into the eukaryotic expression vector pcDNA3.1 / V5 / His B vector
(Balıkesir Üniversitesi, 2020)
Suicide gene therapy has recently emerged as a method used in cancer treatments. These
therapies utilized enzymes that are expressed in the cell. In this study, Staphylococcus
saprophyticus supsp. saprophyticus Nitroreductase ...
Upregulation of PSMD4 gene by hypoxia in prostate cancer cells
(Tubitak Scientific & Technical Research Council Turkey,, 2020)
Ubiquitin-proteasome pathways have a crucial role in tumor progression. PSMD4 (Rpn10, 26S proteasome non-ATPase subunit 4), which is a subunit of the regulatory particle, is a major ubiquitin (Ub) receptor of 26S proteasome. ...
Carbonic anhydrase III is a new target of HIF1 alpha in prostate cancer model
(Elsevier, 2020)
Carbonic Anhydrase III (CAIII) belongs to a member of the alpha Carbonic Anhydrase (CA) family. Although some CA members are strongly up-regulated by HIF1-alpha, it is not known about the transcriptional regulation of CAIII ...
Prodrugs for nitroreductase-based cancer therapy-3: Antitumor activity of the novel dinitroaniline prodrugs/Ssap-NtrB enzyme suicide gene system: Synthesis, in vitro and in silico evaluation in prostate cancer
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2020)
Prodrugs for targeted tumor therapies have been extensively studied in recent years due to not only maximising therapeutic effects on tumor cells but also reducing or eliminating serious side effects on healthy cells. This ...
Prodrugs for nitroreductase based cancer therapy-4: Towards prostate cancer targeting: Synthesis of N-heterocyclic nitro prodrugs, Ssap-NtrB enzymatic activation and anticancer evaluation
(Academic Press Inc Elsevier Science, 2020)
In this study, various N-heterocyclic nitro prodrugs (NHN1-16) containing pyrimidine, triazine and piperazine rings were designed and synthesized. The final compounds were identified using FT-IR, H-1 NMR, C-13 NMR as well ...
TNF-alpha induces URG-4/URGCP gene expression in hepatoma cells through starvation dependent manner
(Springer/Plenum Publishers, 2020)
URG-4/URGCP is a gene that may be associated with the onset of tumorigenesis and cell cycle regulation. In the literature, there is no study about inflammatory cytokine-mediated URG-4/URGCP regulation. In this study, the ...
