Now showing items 1-4 of 4
Prodrugs for nitroreductase based cancer therapy-2: Novel amide/Ntr combinations targeting PC3 cancer cells
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2019)
The use of nitroreductases (NTR) that catalyze the reduction of nitro compounds by using NAD(P)H in GDEPT (Gene-directed enzyme prodrug therapy) studies which minimize toxicity at healthy cells and increases concentration ...
Synthesis and biological evaluation of 2,4,6-trinitroaniline derivatives as potent antitumor agents
(Springer Wien, 2020)
Nitro group-containing compounds are well known as effective anticancer drugs. The aim of the study is to synthesize a series of trinitroaniline derivatives to determine their potential antitumor activities on diverse ...
Prodrugs for nitroreductase-based cancer therapy-3: Antitumor activity of the novel dinitroaniline prodrugs/Ssap-NtrB enzyme suicide gene system: Synthesis, in vitro and in silico evaluation in prostate cancer
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2020)
Prodrugs for targeted tumor therapies have been extensively studied in recent years due to not only maximising therapeutic effects on tumor cells but also reducing or eliminating serious side effects on healthy cells. This ...
Prodrugs for nitroreductase based cancer therapy-5: Development of trinitroaniline Prodrugs/Ssap-NtrB combinations for liver cancer using intracellular and extracellular conditions
(Wiley-V C H Verlag GMBH, 2021)
In this study, a series of trinitroaniline derivatives (TNA1-8) were synthesized and investigated as potential antitumor agents for enzyme-prodrug therapy. Enzymatic efficiency of Ssap-NtrB on prodrug candidates was ...