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Molecular cloning and in silico analysis of human ADAMTS-3 (a disintegrin and metalloprotease with thrombospondin motifs) gene promoter

Alper, Meltem; Köçkar, Feray (Wiley-Blackwell, 2014)

Expression analysis of URG4 (upregulated gene 4) in osteoblast-like cells, Saos-2 and MG63

Köçkar, Feray; Tokay, Esra; Alper, Meltem (Wiley-Blackwell, 2011)

URG4 is a novel gene firstly found in uninfected liver cells stimu-lated by HBxAg (Hepatitis B virus encoded X antigen) and HCC(Hepatocellular Carcinoma) cells. It is associated with cellgrowth, growth factor-independent ...

Characterisation of the human URG-4 (Up-Regulated Gene 4) gene promoter

Köçkar, Feray; Tokay, Esra (Wiley-Blackwell, 2014)

SP1-mediated downregulation of ADAMTS3 gene expression in osteosarcoma models

Alper, Meltem; Aydemir, Ayşe Tugşen; Köçkar, Feray (Elsevier Science, 2018)

ADAMTS3 is a member of procollagen N-proteinase subfamily of ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) gene family. It has an important function in the procollagen maturation process. The ...

Tgf-beta upregulates tumor-associated carbonic anhydrase IX gene expression in Hep3B cells

Yıldırım, Hatice; Köçkar, Feray (Wiley, 2009)

Carbonic anhydrase IX (CAIX) is a membrane-associated carbonic anhydrase (CA) that is overexpressed in a variety of tumor types and associated with increased metastasis, giving a poor prognosis. Transcriptional regulation ...

SP1 is a transcriptional regulator of URG-4/URGCP gene in hepatocytes

Tokay, Esra; Köçkar, Feray (Springer, 2016)

URG-4/URGCP gene was implicated as an oncogene that contributes hepatocarcinogenesis regulated by Hepatitis-B-virus-encoded X antigen. However, the mechanism of transcriptional regulation of this gene remains largely ...

Upregulation of PSMD4 gene by hypoxia in prostate cancer cells

Türkoğlu, Sümeyye Aydoğan; Dayı, Gizem; Köçkar, Feray (Tubitak Scientific & Technical Research Council Turkey,, 2020)

Ubiquitin-proteasome pathways have a crucial role in tumor progression. PSMD4 (Rpn10, 26S proteasome non-ATPase subunit 4), which is a subunit of the regulatory particle, is a major ubiquitin (Ub) receptor of 26S proteasome. ...

USF1 suppresses expression of fibrillar type I, II, and III collagen and pNP adamts-3 in osteosarcoma cells

Alper, M.; Aydemir, T.; Köçkar, Feray (Pleiades Publishing Inc, 2021)

Collagens are the main components of human tissues. Various regulatory factors and cytokines may influence expression levels for collagen-encoding genes, and, therefore, contrubite to some collagenassociated pathologies. ...