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Expression analysis of URG4 (upregulated gene 4) in osteoblast-like cells, Saos-2 and MG63
URG4 is a novel gene firstly found in uninfected liver cells stimu-lated by HBxAg (Hepatitis B virus encoded X antigen) and HCC(Hepatocellular Carcinoma) cells. It is associated with cellgrowth, growth factor-independent ...
Characterisation of the human URG-4 (Up-Regulated Gene 4) gene promoter
SP1-mediated downregulation of ADAMTS3 gene expression in osteosarcoma models
(Elsevier Science, 2018)
ADAMTS3 is a member of procollagen N-proteinase subfamily of ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) gene family. It has an important function in the procollagen maturation process. The ...
Tgf-beta upregulates tumor-associated carbonic anhydrase IX gene expression in Hep3B cells
Carbonic anhydrase IX (CAIX) is a membrane-associated carbonic anhydrase (CA) that is overexpressed in a variety of tumor types and associated with increased metastasis, giving a poor prognosis. Transcriptional regulation ...
SP1 is a transcriptional regulator of URG-4/URGCP gene in hepatocytes
URG-4/URGCP gene was implicated as an oncogene that contributes hepatocarcinogenesis regulated by Hepatitis-B-virus-encoded X antigen. However, the mechanism of transcriptional regulation of this gene remains largely ...
Upregulation of PSMD4 gene by hypoxia in prostate cancer cells
(Tubitak Scientific & Technical Research Council Turkey,, 2020)
Ubiquitin-proteasome pathways have a crucial role in tumor progression. PSMD4 (Rpn10, 26S proteasome non-ATPase subunit 4), which is a subunit of the regulatory particle, is a major ubiquitin (Ub) receptor of 26S proteasome. ...
USF1 suppresses expression of fibrillar type I, II, and III collagen and pNP adamts-3 in osteosarcoma cells
(Pleiades Publishing Inc, 2021)
Collagens are the main components of human tissues. Various regulatory factors and cytokines may influence expression levels for collagen-encoding genes, and, therefore, contrubite to some collagenassociated pathologies. ...