| dc.contributor.author | Rifati-Nixha, Arleta | |
| dc.contributor.author | Arslan, Mustafa | |
| dc.contributor.author | Gencer, Nahit | |
| dc.contributor.author | Çıkrıkcı, Kübra | |
| dc.contributor.author | Gökçe, Başak | |
| dc.date.accessioned | 2021-02-03T08:43:05Z | |
| dc.date.available | 2021-02-03T08:43:05Z | |
| dc.date.issued | 2019 | en_US |
| dc.identifier.issn | 1095-6670 | |
| dc.identifier.issn | 1099-0461 | |
| dc.identifier.uri | https://doi.org/10.1002/jbt.22306 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12462/11040 | |
| dc.description | Gencer, Nahit (Balikesir Author) | en_US |
| dc.description.abstract | The synthesis of carbazole containing pyridopyrimidine-substituted sulfonamide derivatives (3a-i) and their inhibitory effects on human carbonic anhydrase (hCA) I and II were studied. Spectral data and elemental analysis confirmed the structures of the compounds synthesized. The results show that all the synthesized compounds inhibited the CA I and II activities. Among them, 3a was found to be the most active (K-i: 14 mu M) for hCA I and 3f (K-i: 126 mu M) for hCA II. | en_US |
| dc.description.sponsorship | Sakarya Universitesi 2016-02-04-018
Balikesir University 2017/166 | en_US |
| dc.language.iso | eng | en_US |
| dc.publisher | Wiley | en_US |
| dc.relation.isversionof | 10.1002/jbt.22306 | en_US |
| dc.rights | info:eu-repo/semantics/embargoedAccess | en_US |
| dc.subject | Carbazole | en_US |
| dc.subject | Carbonic Anhydrase | en_US |
| dc.subject | Pyridopyrimidine | en_US |
| dc.subject | Sulfonamide | en_US |
| dc.title | Synthesis of carbazole bearing pyridopyrimidine-substituted sulfonamide derivatives and studies their carbonic anhydrase enzyme activity | en_US |
| dc.type | article | en_US |
| dc.relation.journal | Journal of Biochemical and Molecular Toxicology | en_US |
| dc.contributor.department | Fen Edebiyat Fakültesi | en_US |
| dc.contributor.authorID | 0000-0001-7092-8857 | en_US |
| dc.identifier.volume | 33 | en_US |
| dc.identifier.issue | 6 | en_US |
| dc.identifier.startpage | 1 | en_US |
| dc.identifier.endpage | 6 | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
