| dc.contributor.author | Özkahraman, Bengi | |
| dc.contributor.author | Tamahkar, Emel | |
| dc.contributor.author | İdil, Neslihan | |
| dc.contributor.author | Suloğlu, Aysun Kılıç | |
| dc.contributor.author | Perçin, Işık | |
| dc.date.accessioned | 2021-03-05T06:51:40Z | |
| dc.date.available | 2021-03-05T06:51:40Z | |
| dc.date.issued | 2020 | en_US |
| dc.identifier.issn | 0272-4391 | |
| dc.identifier.issn | 1098-2299 | |
| dc.identifier.uri | https://doi.org/10.1002/ddr.2174 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12462/11139 | |
| dc.description | Hitit University Scientific and Technical Application and Research Center | en_US |
| dc.description.abstract | The development of chitosan-gelatin (CS-G) hydrogels embedded with ampicillin-loaded hyaluronic acid nanoparticles (HA-NPs) for wound dressing is proposed. It was aimed to provide controlled ampicillin delivery by incorporation of HA-NPs into biocompatible CS-G hydrogel structure. According to in vitro ampicillin release studies, 55% of ampicillin was released from CS-G/HA-NPs hydrogels after 5 days. Antibacterial performance of CS-G/HA-NPs hydrogels was proven with agar disc diffusion test. For cytotoxicity assay, fibroblast cell viability increased in CS-G/HA-NPs hydrogels compared with CS-G group after 24 hr incubation. Consequently, the potential ability of CS-G/HA-NPs hydrogels as a controlled drug delivery system has been verified. | en_US |
| dc.language.iso | eng | en_US |
| dc.publisher | Wiley | en_US |
| dc.relation.isversionof | 10.1002/ddr.2174 | en_US |
| dc.rights | info:eu-repo/semantics/embargoedAccess | en_US |
| dc.subject | Antibiotic Release | en_US |
| dc.subject | Chitosan-Gelatin Hydrogels | en_US |
| dc.subject | Hyaluronic Acid Nanoparticles Embedding | en_US |
| dc.title | Evaluation of hyaluronic acid nanoparticle embedded chitosan-gelatin hydrogels for antibiotic release | en_US |
| dc.type | article | en_US |
| dc.relation.journal | Drug Development Research | en_US |
| dc.contributor.department | Mühendislik Fakültesi | en_US |
| dc.contributor.authorID | 0000-0003-0914-1128 | en_US |
| dc.contributor.authorID | 0000-0002-5913-8333 | en_US |
| dc.contributor.authorID | 0000-0002-9453-4462 | en_US |
| dc.identifier.volume | Early Access: OCT 2020 | en_US |
| dc.identifier.startpage | 1 | en_US |
| dc.identifier.endpage | 10 | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
