| dc.contributor.author | Arslan, Oktay | |
| dc.date.accessioned | 2019-09-02T12:03:10Z | |
| dc.date.available | 2019-09-02T12:03:10Z | |
| dc.date.issued | 2001 | en_US |
| dc.identifier.issn | 0006-2979 | |
| dc.identifier.uri | https://doi.org/ 10.1023/A:1012365424900 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12462/6171 | |
| dc.description.abstract | Inhibitory effects of three new derivatives of 2-acetylamino-1,3,4-thiadiazole-5-sulfonamide on bovine carbonic anhydrase have been investigated. The new compounds are 2-(3-chloropropionylamino)-1,3,4-thiadiazole-5-sulfonamide, 2-(2,2-dichloroacetylamino)-1,3,4-thiadiazole-5-sulfonamide, and 2-(3-phenylpropionylamino)-1,3,4-thiadiazole-5-sulfonamide. The new compounds inhibit the esterase activity of carbonic anhydrase noncompetitively and have inhibition constants and I-50 values very similar to those for 2-acetylamino-1,3,4-thiadiazole-5-sulfonamide, the latter being clinically used in the treatment of glaucoma. | en_US |
| dc.language.iso | eng | en_US |
| dc.publisher | Maik Nauka/Interperiodica | en_US |
| dc.relation.isversionof | 10.1023/A:1012365424900 | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.subject | Inhibition | en_US |
| dc.subject | Bovine Carbonic Anhydrase | en_US |
| dc.subject | Sulfonamides | en_US |
| dc.title | Inhibition of bovine carbonic anhydrase by new sulfonamide compounds | en_US |
| dc.type | article | en_US |
| dc.relation.journal | Biochemistry-Moscow | en_US |
| dc.contributor.department | Fen Edebiyat Fakültesi | en_US |
| dc.identifier.volume | 66 | en_US |
| dc.identifier.issue | 9 | en_US |
| dc.identifier.startpage | 982 | en_US |
| dc.identifier.endpage | 983 | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
