dc.contributor.author | Özensoy, Özen | |
dc.contributor.author | Arslan, Oktay | |
dc.contributor.author | Işık, Semra | |
dc.contributor.author | Arslan, Mikail | |
dc.contributor.author | Scozzafava, Andrea | |
dc.contributor.author | Supuran, Claudiu T. | |
dc.date.accessioned | 2019-10-17T08:04:34Z | |
dc.date.available | 2019-10-17T08:04:34Z | |
dc.date.issued | 2005 | en_US |
dc.identifier.issn | 1475-6366 | |
dc.identifier.issn | 1475-6374 | |
dc.identifier.uri | https://doi.org/ 10.1080/14756360500141960 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12462/7851 | |
dc.description | Özensoy, Özen (Balıkesir Author) | en_US |
dc.description.abstract | The purification of red blood cell carbonic anhydrase (CA, EC 4.2. 1. 1) from ostrich (scCA) blood is reported, as well as an inhibition study of this enzyme with a series of aromatic and heterocylic sulfonamides. The ostrich enzyme showed a high activity, comparable to that of the human isozyme II, with k(cat) of 1. 2 center dot 10(6) s(-1) and k(cat)/K-M of 1. 8 center dot 10(7)M(-1) s(-1), and an inhibition profile quite different from that of the human red blood cell cytosolic isozymes hCA I and II. scCA has generally a lower affinity for sulfonamide inhibitors as compared to hCA I and II. The only sulfonamide which behaved as a very potent inhibitor of this enzyme was ethoxzolamide (K-1 = 3.9 nM) whereas acetazolamide and sulfanilamide behaved as weaker inhibitors (inhibition constants in the range 303-570 nM). Several other aromatic and heterocyclic sulfonamides, mostly derivatives of sulfanilamide, homosulfanilamide, 4-aminoethylbenzenesulfonamide or 5-amino-1,3,4-thiadiazole-2-sulfonamide, showed good affinities for the ostrich enzyme, with K-1 values in the range 25 - 72 nM. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Taylor & Francis Ltd | en_US |
dc.relation.isversionof | 10.1080/14756360500141960 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Carbonic Anhydrase | en_US |
dc.subject | Sulfonamide | en_US |
dc.subject | Ostrich | en_US |
dc.subject | Inhibitor | en_US |
dc.subject | Enzyme İnhibition | en_US |
dc.title | Carbonic anhydrase inhibitors. Inhibition of red blood cell ostrich (Struthio camelus) carbonic anhydrase with a series of aromatic and heterocyclic sulfonamides | en_US |
dc.type | article | en_US |
dc.relation.journal | Journal of Enzyme Inhibition and Medicinal Chemistry | en_US |
dc.contributor.department | Fen Edebiyat Fakültesi | en_US |
dc.contributor.authorID | 0000-0001-5020-3322 | en_US |
dc.identifier.volume | 20 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.startpage | 383 | en_US |
dc.identifier.endpage | 387 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |