Regenerative methods in osteoarthritis
Özet
Osteoarthritis (OA) is the most common type of arthritis that can
affect all joint structures. The primary goals of osteoarthritis
treatment are to alleviate pain, reduce functional limitations, and
improve quality of life. Despite its high prevalence, treatment
options for osteoarthritis are limited, with most therapeutic approaches focusing on symptom management. Tissue engineering
and regenerative strategies based on biomaterials, cells, and other
bioactive molecules have emerged as viable options for osteoarthritis cartilage repair. Platelet-rich plasma (PRP) and mesenchymal stem cells (MSCs) are the most commonly used
regenerative therapies today to protect, restore, or increase the
function of damaged tissues. Despite promising results, there is
conflicting evidence regarding the efficacy of regenerative therapies, and their efficacy remains unknown. The data suggest that
more research and standardization are required for the use of
these therapies in osteoarthritis. This article provides an overview
of the application of MSCs and PRP applications.