Moleküler Biyoloji ve Genetik-Makale Koleksiyonu
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Prodrugs for nitroreductase based cancer therapy-5: Development of trinitroaniline Prodrugs/Ssap-NtrB combinations for liver cancer using intracellular and extracellular conditions
(Wiley-V C H Verlag GMBH, 2021)In this study, a series of trinitroaniline derivatives (TNA1-8) were synthesized and investigated as potential antitumor agents for enzyme-prodrug therapy. Enzymatic efficiency of Ssap-NtrB on prodrug candidates was ... -
USF1 suppresses expression of fibrillar type I, II, and III collagen and pNP adamts-3 in osteosarcoma cells
(Pleiades Publishing Inc, 2021)Collagens are the main components of human tissues. Various regulatory factors and cytokines may influence expression levels for collagen-encoding genes, and, therefore, contrubite to some collagenassociated pathologies. ... -
Essential oil chemical composition, antimicrobial, anticancer, and antioxidant effects of Thymus convolutus Klokov in Turkey
(Walter De Gruyter GMBH, 2021)In this study, the chemical composition, antimicrobial, antioxidant, and anticancer effects of Thymus convolutus Klokov oil and its main compound camphor were investigated. The oil was isolated from T. convolutus using ... -
Immobilized xanthine oxidase with bio-composite using gas biosensor
(Parlar Scientific Publications (P S P), 2021)The paper describes the development of biosensor for gas detection using bio-composite-xanthine oxidase. The xanthine oxidase enzyme is immobilized by bio-composite including gelatine and chitosan. The high stability of ... -
Epidermal growth factor mediates up-regulation of URGCP oncogene in human hepatoma cancer cells
(Pleiades Publishing Inc, 2021)Hepatocellular Carcinoma (HCC) is the fourth leading cause of cancer-related death in the World. Epidermal Growth Factor Receptor (EGFR) pathway plays an important role in HCC tumorigenesis. In the tumor microenvironment ... -
Metal ion effects on Polyphenol Oxidase Covalently immobilized on a Bio-Composite
(C M B Assoc, 2021)Biosensors can be developed using different immobilization methods. Interest in immobilization methods have increased because biosensors have been important for science. Polyphenol oxidase (PPO) was used generally in ... -
Synthesis and characterization of poly(acrylic acid)/nanohydroxyapatite nanocomposite hydrogels and evaluation of its antibacterial, bio- and hemo-compatibility characteristics
(Taylor & Francis, 2021)PAA/nHAp was synthesized by solvent casting method and characterized by different techniques. nHAp was homogeneously dispersed in nano-sized in PAA matrix. The thermal properties and glass transition temperatures of ... -
Multidrug resistance gene expression response to cisplatin and 5FU treatment in hepatoma, prostate and colon cancer cells
(Balıkesir Üniversitesi, 2020)Variable expression of drug transporters at the plasma membrane of tumor cells contributed to drug resistance. The aim of the present study was to explore the expression levels of MRP2 and MRP3genes in Cisplatin and 5 ... -
Cloning of ADAMTS2 gene and colony formation effect of ADAMTS2 in Saos-2 cell line under normal and hypoxic conditions
(Adıyaman Üniversitesi, 2020)ADAMTS2 (a disintegrin and metalloproteinase with thrombospondin motifs 2), an N- propeptidase isoenzyme, is an enzyme involved in collagen biosynthesis by providing the amino ends of procollagen to be cut away. ADAMTS2 ... -
Cloning of the Ssap-NtrB prokaryotic gene into the eukaryotic expression vector pcDNA3.1 / V5 / His B vector
(Balıkesir Üniversitesi, 2020)Suicide gene therapy has recently emerged as a method used in cancer treatments. These therapies utilized enzymes that are expressed in the cell. In this study, Staphylococcus saprophyticus supsp. saprophyticus Nitroreductase ... -
Development and characterization of superparamagnetic nanomaterial to determine its potential application in removing the bitterness of table olives
(MYU, 2020)The aim of this study is to develop stable superparamagnetic iron oxide nanoparticles (SPIONs) for the immobilization of beta-glucosidase. The goal is to figure out the possibility of applying immobilization techniques in ... -
Preparing and optimizing a newly affinity gel for purification of carbonic anhydrase isoenzymes
(Parlar Scientific Publications (P S P), 2020)Human carbonic anhydrase isozymes have been purified from the hemolysate, directly by using the original affinity gel in chemical structure of Sepharose 4B-L-tyrosine- sulfathiazole. Different solution buffers were used ... -
Inhibitory effects of anticancer drugs on cytosolic carbonic anhydrase isozymes
(Parlar Scientific Publications (P S P), 2020)Anticancer drugs are widely used cancer treatment. Human carbonic anhydrase I and II were shown widely distribution with erythrocytes so it is important to understand how effect is anticancer drugs these isozymes. In this ... -
The chemical components, antioxidant and anticancer activities of ziziphus jujube extracts from Turkey
(Agrimedia GMBH, 2020)The bioactive components which are nutritionally and medically important of jujube fruit have been shown to vary with growing conditions. In this study, the cytotoxic effect of Ziziphus jujube fruit, which is in two different ... -
Immobilization xanthine oxidase on interdigitated electrode for biosensor investigation
(Parlar Scientific Publications (P S P), 2020)Biosensors can be developed using different biological materials and immobilization technologies. Interest in immobilization techniques has increased because they allow for the improvement of some stability characteristics ... -
Upregulation of PSMD4 gene by hypoxia in prostate cancer cells
(Tubitak Scientific & Technical Research Council Turkey,, 2020)Ubiquitin-proteasome pathways have a crucial role in tumor progression. PSMD4 (Rpn10, 26S proteasome non-ATPase subunit 4), which is a subunit of the regulatory particle, is a major ubiquitin (Ub) receptor of 26S proteasome. ... -
Inhibition effect of some chemical on lactoperoxidase and covalently immobilized on a biocomposite for biosensor
(Parlar Scientific Publications (P S P), 2020)Lactoperoxidase was purified from bovine milk using ammonium sulfate precipitation and affinity chromatography. The greatest purification fold for lactoperoxidase has been obtained as 1302.65 folds with 24.95 % yields. The ... -
Prodrugs for nitroreductase-based cancer therapy-3: Antitumor activity of the novel dinitroaniline prodrugs/Ssap-NtrB enzyme suicide gene system: Synthesis, in vitro and in silico evaluation in prostate cancer
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2020)Prodrugs for targeted tumor therapies have been extensively studied in recent years due to not only maximising therapeutic effects on tumor cells but also reducing or eliminating serious side effects on healthy cells. This ... -
Molecular cloning and biochemical characterization of a Tau class glutathione S-transferase from Pinus brutia Ten
(Springer Heidelberg, 2020)Key message A new Tau class GST gene was cloned from Pinus brutia Ten. cDNA sequence was analysed for conserved sequences. Substrate specificity, optimum pH, and temperature values of the recombinant PbGST Tau enzyme were ... -
Evaluation of Azadirachtin on Arthrospira plantensis Gomont growth parameters and antioxidant enzymes
(EDP Sciences S A, 2020)To understand the effects of contamination of insecticides onphototrophs, and to determine the responses of these organisms against these chemicals are extremely important in understanding how the ecosystem is affected. ...
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