• Hypoxic regulation of the klk4 gene in two different prostate cancer cells treated with TGF- β 

  Poyrazlı, Fatma; Okuyan, Derya; Türkoğlu, Sümeyye Aydoğan; Köçkar, Feray (Springer, 2024)

  The human kallikrein-related peptidase (KLK) family which consists of 15 members is associated with prostate cancer and other cancers. It has been reported that overexpression of KLK4 in prostate cancer correlates with ...

• Selagibenzophenone b and its derivatives: Selb-1, a dual topoisomerase I/II inhibitor identified through in vitro and in silico analyses 

  Dönmez, Serhat; Lapinskaite, Ringaile; Atalay, Hazal Nazlıcan; Tokay, Esra; Köçkar, Feray; Rycek, Lukas; Özbil, Mehmet; Tumer, Tuğba Boyuneğmez (American Chemical Society, 2024)

  The development of multitargeted drugs represents an innovative approach to cancer treatment, aiming to enhance drug effectiveness while minimizing side effects. Herein, we sought to elucidate the inhibitory effect of ...

• Terbium (III) and salicylamide doped nickel ferrite (NiFe2O4) nanoparticles synthesized from Olea europaea L. plant extracts via eco-friendly green synthesis approach and co-precipitation method 

  Kızılduman, Berna Koçer; Diken, Mehmet Emin; Doğan, Mehmet; Çoban, Mustafa Burak (Elsevier Ltd, 2024)

  An eco-friendly and cost-effective NiFe2O4 nanoparticles and its derivatives NiFe2O4:salicylamide, NiFe2O4:salicylamide:Tb3+ and NiFe2O4:salicylamide:Tb3+:Olea europaea L. extracts have been successfully synthesized using ...

• Changes in paraoxonase, β-glucosidase, and carbonic anhydrase enzymes related to age and scopolamine-induced memory impairment in rats 

  Yıldırım, Hatice; Aksöz, Elif; Daşkan, Burcu Efe; Şen, Fazilet; Çelebi, Murat (Multidisciplinary Digital Publishing Institute (MDPI), 2024)

  This study aimed to investigate the changes in Paraoxonase (PON), Carbonic Anhydrase (CA), and β-glucosidase levels of different aged rats and scopolamine-induced memory impairment rats. This study used young, adult, and ...

• In vitro and in silico analyses of cytoprotective, antigenotoxic and antimutagenic potential of Phlomis pungens var. Hirta extracts against oxidative damage 

  Korkmaz, Franziska Johanna Wild; Doğan, Serap; Kardaş, Begümhan Yılmaz; Diken, Mehmet Emin; Karasakal, Ömer Faruk; Acar, Mikail (Springer, 2024)

  Phlomis pungens var. hirta Velen has been used by local people for food and to treat diseases but there are limited number of investigations in literature about this plant and cyto/genotoxicity analyses have not been done ...

• In silico and in vitro determination of potential RSK inhibitors for colon cancer therapy 

  Mülhim, Ufuk; Tokay, Esra; Köçkar, Feray; Kalın, Sevil; Önder, F. Cömert (Wiley, 2024)

  The Ribosomal S6 kinase (RSK) family comprises four isoforms (RSK1/2/3/4), functioning as serine/threonine kinases. RSK plays a crucial role in various physiological processes like cell growth, proliferation, and migration. ...

• Effects of IL-6 and TNF-α cytokines on cell proliferation in androgen dependent/independent prostate cancer cell lines 

  Onat, Serhad; Türkoğlu, Sümeyye Aydoğan; Köçkar, Feray (Çanakkale Onsekiz Mart University, 2024)

  Abstract − Prostate cancer is the second most common types of cancer among men worldwide. Prostate cancer, caused by abnormal and uncontrolled growth of the cells that make up the prostate tissue, is second only to ...

• In-vitro apoptotic and metastatic effect of ibuprofen on hepatocellular carcinoma cells 

  Tokay, Esra; Köçkar, Feray (Wiley, 2024)

  Ibuprofen (2RS)­1 [4­(2­methylpropyl)phenyl] propionic acid is the first derivative of propionic acid developed in 1969 as an alternative to aspirin. In the literature, it has been determined that ibuprofen has a favorable ...

• In-vitro SMA model; SMN1 gene knockdown in SH-SY5Y cells 

  Tokay, Esra; Çapraz, Hasan; Köçkar, Feray (Wiley, 2024)

  Spinal muscular atrophy is an autosomal­recessive disorder characterized by degeneration of motor neurons in the spinal cord and caused by mutations in the survival motor neuron 1 gene, SMN1. The phenotype is extremely ...

• Antigenotoxic properties of different plant oils and the influence of olfactory bias 

  Kardaş, Begümhan Yılmaz (Sivas Cumhuriyet Üniversitesi, 2024)

  In this study, antigenotoxic effects and developmental toxicity of frankincense and blue anemone oils were aimed to be analysed and the olfactory bias was aimed to be checked to see the possibility of an interaction ...

• Oxidative stress in Arthrospira platensis by two organophosphate pesticides 

  Tunca, Hatice; Doğru, Ali; Köçkar, Feray; Kılıç, Hediye E.; Sevindik, Tuğba O. (Acad Brasileira de Ciencias, 2023)

  Although it is known that organophosphate insecticides are harmfull to aquatic ecosystems, oxidative damages caused by Dimethoate and Chlorpyrifos are not studied on Arthrospira platensis Gomont. In this study, various ...

• Phylogenetic analysis of ziziphora (lamiaceae) using nuclear (nrITS) and plastid (trnL-F) DNA: suggestions for new arrangements and status changes 

  Dündar, Ekrem; Tümen, Gülendam (Taylor and Francis Ltd., 2023)

  In this study, Ziziphora taxa grown in Turkey along with those grown in different parts of the world were analyzed with respect to morphological revision and molecular systematic analyses using nuclear ribosomal ITS (nrITS) ...

• Is phenytoin a safe agent for staple line recovery after gastric sleeve surgery in rats? 

  Çay, Ferhat; Duran, Ali; Tokay, Esra; Hacıoğlu, Nelin; Köçkar, Feray; Altun, Eren; Kanat, Burhan Hakan (Turkish Association of Trauma and Emergency Surgery, 2023)

  BACKGROUND: The most challenging and mortal complication of gastric sleeve surgery (SG) is staple line leakage. Although many agents have been used for increasing tissue healing on the stapler line, there is still no ...

• Characterization of lactoperoxidase (LPO) enzyme thin films for Volatile Organic Compound (VOC) sensing 

  Evyapan, Murat; Uzunoğlu, Serap Beyaztaş; Uzunoǧlu, Tayfun (Taylor and Francis Ltd., 2023)

  Spin-coated thin films of lactoperoxidase enzyme (LPO) were used on conjunction with the bio-composite (chitosan-gelatin), glutaraldehyde and cysteine as first-layers to characterize the interactions on the sensing ...

• Cu(II) coordination polymers containing dicyanamide and 2,2′-bipyridine: structural and antibacterial properties 

  Hopa, Çiğdem; Yavuz, Abdülkerim; Dikmen, Mehmet Emin; Güngör, Elif (Pleiades Publishing, 2023)

  From reaction mixture containing the same reagents, the two Cu(II) complexes, with dicyanamide (dca) bridges, [Cu(bpy)(dca)2] n (1) and [Cu(bpy)Cl(dca)] n·H2O (2) (bpy = 2,2′-bipyridine) were prepared. The complexes were ...

• Cytotoxic and anti-metastatic effects of Hypericum perforatum olive oil extract in colorectal cancer cells and human bone marrow derived stem cells 

  Yıldırım, Hatice; Daşkan, Burcu Efe (Taylor and Francis Ltd., 2023)

  This study is aimed to investigate the effects of Hypericum perforatum olive oil extract on the cytotoxic and metastatic properties of human colorectal cancer cells and human bone marrow-derived mesenchymal stem cells. In ...

• Regional expression differences of SERT and TSPAN8 in hippocampus, cerebellum and cortex of wild-type young, adult and middle-aged rats 

  Yıldırım, Hatice; Daşkan, Burcu Efe; Aksöz, Elif; Sen, Fazilet; Çelebi, Murat (Elsevier, 2023)

  Changes in gene expression with aging are associated with a decline in physical and cognitive abilities. Here, we investigated the changes in mRNA and protein expression of TSPAN8 and SERT in the different parts of the ...

• Inhibitory effect on acetylcholinesterase and toxicity analysis of some medicinal plants 

  Diken, Mehmet Emin; Kardaş, Begümhan Yılmaz (İzzet Kara, 2022)

  This study aimed to analyse the inhibition of different extracts of Rosmarinus officinalis, Pistacia terebinthus and Sideritis dichotoma on acetylcholinesterase enzyme of Drosophila melanogaster. Additionally, the ...

• The effects of mutations on pericentromeric localization of shugoshin 

  Kardaş, Begümhan Yılmaz; Doğan, Serap (Balıkesir Üniversitesi, 2022)

  Elucidating the effects of mutations on protein-protein interactions can be useful for detecting damaged biological functions like chromosome segregations, because cellular structure and functions are mainly built on ...

• The effects of the plant growth regulators on antioxidant enzymes 

  Doğan, Serap; Pektaş, İlknur; Diken, Mehmet Emin; Kardaş, Begümhan Yılmaz; Doğan, Mehmet; Kocatürk, Berker (Parlar Scientific Publications (P S P ), 2022)

  This study describes in vitro the effect of three plant growth regulators (PGRs) such as mepiquat chloride, beta-naphthoxyacetic acid and gibberellic acid on the human blood antioxidant enzyme activites of glucose-6-phosphate ...

Daha Fazla