• Oxidative stress in Arthrospira platensis by two organophosphate pesticides 

  Tunca, Hatice; Doğru, Ali; Köçkar, Feray; Kılıç, Hediye E.; Sevindik, Tuğba O. (Acad Brasileira de Ciencias, 2023)

  Although it is known that organophosphate insecticides are harmfull to aquatic ecosystems, oxidative damages caused by Dimethoate and Chlorpyrifos are not studied on Arthrospira platensis Gomont. In this study, various ...

• Phylogenetic analysis of ziziphora (lamiaceae) using nuclear (nrITS) and plastid (trnL-F) DNA: suggestions for new arrangements and status changes 

  Dündar, Ekrem; Tümen, Gülendam (Taylor and Francis Ltd., 2023)

  In this study, Ziziphora taxa grown in Turkey along with those grown in different parts of the world were analyzed with respect to morphological revision and molecular systematic analyses using nuclear ribosomal ITS (nrITS) ...

• Is phenytoin a safe agent for staple line recovery after gastric sleeve surgery in rats? 

  Çay, Ferhat; Duran, Ali; Tokay, Esra; Hacıoğlu, Nelin; Köçkar, Feray; Altun, Eren; Kanat, Burhan Hakan (Turkish Association of Trauma and Emergency Surgery, 2023)

  BACKGROUND: The most challenging and mortal complication of gastric sleeve surgery (SG) is staple line leakage. Although many agents have been used for increasing tissue healing on the stapler line, there is still no ...

• Characterization of lactoperoxidase (LPO) enzyme thin films for Volatile Organic Compound (VOC) sensing 

  Evyapan, Murat; Uzunoğlu, Serap Beyaztaş; Uzunoǧlu, Tayfun (Taylor and Francis Ltd., 2023)

  Spin-coated thin films of lactoperoxidase enzyme (LPO) were used on conjunction with the bio-composite (chitosan-gelatin), glutaraldehyde and cysteine as first-layers to characterize the interactions on the sensing ...

• Cu(II) coordination polymers containing dicyanamide and 2,2′-bipyridine: structural and antibacterial properties 

  Hopa, Çiğdem; Yavuz, Abdülkerim; Dikmen, Mehmet Emin; Güngör, Elif (Pleiades Publishing, 2023)

  From reaction mixture containing the same reagents, the two Cu(II) complexes, with dicyanamide (dca) bridges, [Cu(bpy)(dca)2] n (1) and [Cu(bpy)Cl(dca)] n·H2O (2) (bpy = 2,2′-bipyridine) were prepared. The complexes were ...

• Cytotoxic and anti-metastatic effects of Hypericum perforatum olive oil extract in colorectal cancer cells and human bone marrow derived stem cells 

  Yıldırım, Hatice; Daşkan, Burcu Efe (Taylor and Francis Ltd., 2023)

  This study is aimed to investigate the effects of Hypericum perforatum olive oil extract on the cytotoxic and metastatic properties of human colorectal cancer cells and human bone marrow-derived mesenchymal stem cells. In ...

• Regional expression differences of SERT and TSPAN8 in hippocampus, cerebellum and cortex of wild-type young, adult and middle-aged rats 

  Yıldırım, Hatice; Daşkan, Burcu Efe; Aksöz, Elif; Sen, Fazilet; Çelebi, Murat (Elsevier, 2023)

  Changes in gene expression with aging are associated with a decline in physical and cognitive abilities. Here, we investigated the changes in mRNA and protein expression of TSPAN8 and SERT in the different parts of the ...

• Inhibitory effect on acetylcholinesterase and toxicity analysis of some medicinal plants 

  Diken, Mehmet Emin; Kardaş, Begümhan Yılmaz (İzzet Kara, 2022)

  This study aimed to analyse the inhibition of different extracts of Rosmarinus officinalis, Pistacia terebinthus and Sideritis dichotoma on acetylcholinesterase enzyme of Drosophila melanogaster. Additionally, the ...

• The effects of mutations on pericentromeric localization of shugoshin 

  Kardaş, Begümhan Yılmaz; Doğan, Serap (Balıkesir Üniversitesi, 2022)

  Elucidating the effects of mutations on protein-protein interactions can be useful for detecting damaged biological functions like chromosome segregations, because cellular structure and functions are mainly built on ...

• The effects of the plant growth regulators on antioxidant enzymes 

  Doğan, Serap; Pektaş, İlknur; Diken, Mehmet Emin; Kardaş, Begümhan Yılmaz; Doğan, Mehmet; Kocatürk, Berker (Parlar Scientific Publications (P S P ), 2022)

  This study describes in vitro the effect of three plant growth regulators (PGRs) such as mepiquat chloride, beta-naphthoxyacetic acid and gibberellic acid on the human blood antioxidant enzyme activites of glucose-6-phosphate ...

• Kolon Kanserinde IL-6 Sitokinin Karbonik anhidraz III Gen İfadesi Üzerindeki Etkisinin İncelenmesi 

  Okuyan, Derya; Köçkar, Feray; Türkoğlu, Sümeyye Aydogan (2023)

  Yüksek IL-6 seviyeleri, birçok kanser türünde agresif tümör büyümesi ve tedaviye yanıt ile ilişkilidir. Dolaşımdaki IL-6 düzeyi yüksek olan hastalar genellikle kötü prognoz ve daha kısa sağkalım ile ilişkilendirilirken, ...

• Novel perylene diimide based antiproliferative chromophores 

  Özçil, Furkan; Karaman, Merve; Yıldırım, Hatice; Yükrük, Funda (2023)

  The primary objective of the work was to monitor the antiproliferative activity of two newly synthesized and described perylene diimides. The MTT test was used to investigate the antiproliferative effect against PC3 the ...

• Expression pattern of adamts-3 (A disintegrin and matrix metalloproteinase type,1 motif 3) in normal and cancer cell lines 

  Alper, Meltem; Aydemir, A. Tuğşen; Köçkar, Feray (2022)

  ADAMTS-3 is a procollagen N- proteinase whose main function is to cleave procollagen II, the principal collagen of the cartilage and bone. This maturation process provides accurate fibril conformation for tissues. Along ...

• Strigolactone analogs: Two new potential bioactiphores for glioblastoma 

  Antika, Gizem; Çınar, Zeynep Özlem; Hınıslıoğlu, Esma Seçen; Özbil, Mehmet; Tokay, Esra; Köçkar, Feray; Prandi, Cristina; Tümer, Tuğba Boyuneğmez (Amer Chemical Soc, 2022)

  Strigolactones (SLs), carotenoid-derived phytohormones, control the plant response and signaling pathways for stressful conditions. In addition, they impact numerous cellular processes in mammalians and present new scaffolds ...

• Antibacterial and antioxidant phenolic compounds loaded PCL biocomposites for active food packaging application 

  Diken, Mehmet Emin; Kızılduman, Berna Koçer; Doğan, Serap; Doğan, Mehmet (Wiley, 2022)

  Active food packages must not only act as a protective food barrier but also exhibit radical scavenging activity, antibacterial and controlled release properties that can have a positive effect on food quality, safety and ...

• Investigation of the effects of post-operative intraperitoneal, oral, and rectal phenytoin administration on colorectal anastomosis in rats 

  Duran, Ali; Çay, Ferhat; Hacıoğlu, Nelin; Tokay, Esra; Köçkar, Feray; Altun, Eren; Başbuğ, Murat; Şahin, Azad Gazi (Turkish Assoc Trauma Emergency Surgery, 2022)

  BACKGROUND: Anastomotic leakage is the most feared complication after colonic anastomosis. The purpose of the study is to determine the effects of phenytoin applied by different application routes, on the healing process ...

• Hypoxic regulation of ADAMTS-2 and-3 (a disintegrin and matrix metalloproteinase with thrombospondin motifs 2 and 3) procollagen N proteinases by HIF-1 alpha in endothelial cells 

  Altuntaş, Candan; Alper, Meltem; Keleş, Yasemin; Sav, Feyza Nur; Köçkar, Feray (Springer, 2023)

  ADAMTS-2 and ADAMTS-3, known as procollagen amino proteases (PNP), are primarily responsible for processing the amino ends of the fbrillar collagen precursors. ADAMTS-2 is a highly expressed gene in type I collagen-rich ...

• Cytoprotective, antimutagenic/antirecombinogenic and antibacterial properties of Lallemantia iberica extracts 

  Kardaş, Begümhan Yılmaz; Diken, Mehmet Emin; Bayhan, Hamza; Acar, Mikail; Doğan, Serap (Wiley, 2022)

  BACKGROUND: Plants have important chemical compounds to protect organisms from many mutagens but they may also have dangerous toxic substances that must be tested before use. Lallemantia iberica has been used by local ...

• Hipoksi ve kanser 

  Türkoğlu, Sümeyye Aydoğan; Poyrazlı, Fatma; Okuyan, Derya; Köçkar, Feray (Çanakkale Onsekiz Mart Üniversitesi Fen Bilimleri Enstitüsü, 2021)

  Dokudaki gerekli oksijen seviyesinin normal değerin altına düşmesi hipoksi olarak tanımlanır. Hipoksi katı tümörlerde sık karşılaşılan bir durumdur. Tümör hücreleri yeterli oksijen alamadığında hücre ölümüne gitmeden ...

• Prodrugs for nitroreductase based cancer therapy-5: Development of trinitroaniline Prodrugs/Ssap-NtrB combinations for liver cancer using intracellular and extracellular conditions 

  Hacıoğlu, Nelin; Güngör, Tuğba; Tokay, Esra; Gülhan, Ünzile Güven; Çelik, Ayhan; Ay, Mehmet; Köçkar, Feray (Wiley-V C H Verlag GMBH, 2021)

  In this study, a series of trinitroaniline derivatives (TNA1-8) were synthesized and investigated as potential antitumor agents for enzyme-prodrug therapy. Enzymatic efficiency of Ssap-NtrB on prodrug candidates was ...

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