Temel Tıp Bilimleri-Makale Koleksiyonu: Recent submissions
Now showing items 41-60 of 284
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Investigation of the anticancer mechanism of monensin via apoptosis-related factors in SH-SY5Y neuroblastoma cells
(Wiley, 2023)Monensin is an ionophore antibiotic that inhibits the growth of cancer cells. The aim of this study was to investigate the apoptosis-mediated anticarcinogenic effects of monensin in SH-SY5Y neuroblastoma cells. The effects ... -
Modulation of melatonin receptors regulates reproductive physiology: The impact of agomelatine on the estrus cycle, gestation, offspring, and uterine contractions in rats
(Acad Sciences Czech Republic, 2023)Agomelatine is a pharmaceutical compound that functions as an agonist for melatonin receptors, with a particular affinity for the MT1 and MT2 receptor subtypes. Its mode of action is integral to the regulation of diverse ... -
A cross-cultural analysis for plastic waste perception of students from Romania and Turkey
(MDPI, 2023)The article brings to attention a cross cultural model related to the perception of students in relation to the current problem of plastic waste. To create the model, a questionnaire was applied online in two countries at ... -
Treadmill exercise improves behavioral and neurobiological alterations in restraint-stressed rats
(Springer Nature, 2023)Stress is a state that is known to impact an organism's physiological and psychological balance as well as the morphology and functionality of certain brain areas. In the present work, chronic restraint stress (CRS) model ... -
Development and validation of liquid chromatography/stable isotope-dilution tandem mass spectrometry method for measurement of dexamethasone, total cortisol and free cortisol in human plasma
(Dokuz Eylul Univ Inst Health Sciences, 2023)Background Cortisol plays a role in the regulation of metabolic homeostasis. Dexamethasone is a powerful synthetic glucocorticoid that acts as an anti-inflammatory and immunosuppressive agent. Plasma free cortisol, which ... -
Therapeutic potential of mesenchymal stem cell-derived conditioned medium for diabetes mellitus and related complications
(Wiley, 2023)Diabetes mellitus (DM) is one of the most life-threatening metabolic disorders, with 9% of the global prevalence, and it is estimated to be rising to 12.2% in 2045. Currently, there is no definitive treatment for DM. ... -
Protective effect of pomegranate juice on lead acetate-induced liver toxicity in male rats
(Pera Yayıncılık Hizmetleri, 2023)Objective: Lead has been reported to cause oxidative stress in liver tissues and cause histopathological changes. Studies have shown that pomegranate juice has antioxidant properties that prevent oxidative stress. In this ... -
Effects of monensin and rapamycin combination therapy on tumor growth and apoptosis in a xenograft mouse model of neuroblastoma
(MDPI, 2023)Neuroblastoma is the most common pediatric solid tumor originating from the neural crest. New treatment options are needed to improve treatment outcomes and the survival of patients with neuroblastoma. Monensin is an ... -
The relationship of circulating MOTS-c level with liver fibrosis and metabolic components in patients with metabolic dysfunction-associated fatty liver disease
(Verduci Publisher, 2023)OBJECTIVE: Mitochondrial open reading frame of the 12s ribosomal RNA type-c (MOTS-c) is a novel identified mitochondrial signal transmission peptide that plays an important role in glucose, amino acid and lipid metabolism. ... -
The frequency of thyroid dysfunction in patients with a diagnosis of depressive disorder
(Wolters Kluwer Medknow Publications, 2023)Objective: Thyroid dysfunctions are among the most common endocrine disorders in society. An increase or decrease in thyroid hormone levels may present with neurological and/or psychiatric symptoms. In this study, we aimed ... -
Evaluation of volumetric asymmetry of the dorsolateral prefrontal cortex and medial temporal lobe in Alzheimer's disease using the atlas-based method
(Lippincott Williams and Wilkins, 2023)Brain areas affected during neurodegenerative disease progression are considered anatomically connected to the first affected areas. The dorsolateral prefrontal cortex (DLPFC) has connections with the medial temporal lobe ... -
Investigation of the TLR4 and IRF3 signaling pathway-mediated effects of monensin in colorectal cancer cells
(Springer, 2023)Monensin is an ionophore antibiotic isolated from Streptomyces cinnamonensis with very strong antibacterial and antiparasitic effects. Although monensin is known to exhibit anticancer activity in different cancer types, ... -
Distribution of fungemia agents in five years and antifungal resistance
(Verduci Editore S.R.L., 2023)OBJECTIVE: Recent research has suggested that fungemia may demonstrate an epidemiologic shift in etiologic agents. This study focuses on the agents causing fungemia and antifungal resistance in a tertiary hospital. PATIENTS ... -
Comparison of clinical categories, blood biomarkers and cycle threshold value in COVID-19
(Bayrakol Medical Publisher, 2023)Aim: The aim of this study is to investigate whether the viral load of SARS-CoV-2 is an important factor in predicting disease severity and its relationship with clinical and biochemical parameters.Material and Methods: ... -
Measuring radon concentration and investigation of it's effects on lung cancer
(Elsevier, 2023)The second most significant etiological factor contributing to the development of lung cancer, following tobacco smoking, is the presence of radon gas. Hence, the assessment of indoor radon levels within residential ... -
Measurement of soil radon concentration in Balikesir and examination of its effects on health
(Elsevier, 2023)Most of the natural radiation originates from radon, approximately 55%. This radiation occurs because of the radioactive decay of natural uranium found in rocks, soil and water. Because radon is in gaseous form, it ... -
Effects of the recurrent and different doses of ketamine exposure on anxiety-like behaviors and locomotor activity in juvenile rats
(Bentham Science Publ Ltd, 2022)Background: Ketamine is a widely used anesthetic agent. Although the potential adverse effects of ketamine use in juvenile age are uncertain, certain studies reported that children exposed to recurrent anesthesia could ... -
Firmicutes/Bacteroidetes Ratio in the Gut Microbiota and IL-10, IL-6, IL-8, TLR2, TLR4, TLR5 Gene Expressions in Type 2 Diabetes
(Clin Lab Publ, 2022)Background: The aim of this study was to determine the Firmicutes/Bacteroidetes ratio in the gut microbiota and IL-1β, IL-6, IL-8, TLR2, TLR4 and TLR5 gene expression levels in the blood of adult type 2 diabetes (T2D) ... -
Kan kültürlerinden izole edilen candida türlerinin araştırılması
(2021)Amaç: Candida türleri, mortalitesi yüksek ciddi klinik tablolara neden olabilmektedir. Geniş spektrumlu antibiyotiklerin kullanımı, immünsupresyon, invaziv tıbbi işlemler ve yoğun bakım ünitelerinde yatış süresinin ... -
Effect of metaclopramide on urinary bladder smooth muscle contraction-relaxation mechanism
(2022)Objectives: Metoclopramide, a dopamine receptor antagonist, a benzamide, is a commonly used antiemetic drug in many diseases with nausea and vomiting. The aim of this study is to examine the effects of metoclopramide, which ...
