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dc.contributor.authorKoç, Emine Rabia
dc.contributor.authorGökçe, Emre Cemal
dc.contributor.authorSönmez, Mehmet Akif
dc.contributor.authorNamuslu, Mehmet
dc.contributor.authorGökçe, Aysun
dc.contributor.authorBodur, Abdurrahman Said
dc.date.accessioned2019-11-18T12:22:10Z
dc.date.available2019-11-18T12:22:10Z
dc.date.issued2015en_US
dc.identifier.issn1052-3057
dc.identifier.issn1532-8511
dc.identifier.urihttps://doi.org/10.1016/j.jstrokecerebrovasdis.2014.07.037
dc.identifier.urihttps://hdl.handle.net/20.500.12462/9877
dc.descriptionKoç, Emine Rabia (Balikesir Author)en_US
dc.description.abstractObjectives: The aim of this study is to investigate the potential effects of borax on ischemia/reperfusion injury of the rat spinal cord. Methods: Twenty-one Wistar albino rats were divided into 3 groups: sham (no ischemia/reperfusion), ischemia/reperfusion, and borax (ischemia/reperfusion + borax); each group was consist of 7 animals. Infrarenal aortic cross clamp was applied for 30 minutes to generate spinal cord ischemia. Animals were evaluated functionally with the Basso, Beattie, and Bresnahan scoring system and inclined-plane test. The spinal cord tissue samples were harvested to analyze tissue concentrations of nitric oxide, nitric oxide synthase activity, xanthine oxidase activity, total antioxidant capacity, and total oxidant status and to perform histopathological examination. Results: At the 72nd hour after ischemia, the borax group had significantly higher Basso, Beattie, and Bresnahan and inclined-plane scores than those of ischemia/reperfusion group. Histopathological examination of spinal cord tissues in borax group showed that treatment with borax significantly reduced the degree of spinal cord edema, inflammation, and tissue injury disclosed by light microscopy. Xanthine oxidase activity and total oxidant status levels of the ischemia/reperfusion group were significantly higher than those of the sham and borax groups (P >.05), and total antioxidant capacity levels of borax group were significantly higher than those of the ischemia/reperfusion group (P > .05). There was not a significantly difference between the sham and borax groups in terms of total antioxidant capacity levels (P > .05). The nitric oxide levels and nitric oxide synthase activity of all groups were similar (P >.05). Conclusions: Borax treatment seems to protect the spinal cord against injury in a rat ischemia/reperfusion model and improve neurological outcome.en_US
dc.description.sponsorshipTurgut Ozal University - P53011220 Gen_US
dc.language.isoengen_US
dc.publisherElsevier Science Bven_US
dc.relation.isversionof10.1016/j.jstrokecerebrovasdis.2014.07.037en_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectBoraxen_US
dc.subjectSpinal Corden_US
dc.subjectIschemiaen_US
dc.subjectReperfusion Injuryen_US
dc.subjectNeuroprotectionen_US
dc.subjectOxidative Stressen_US
dc.titleBorax partially prevents neurologic disability and oxidative stress in experimental spinal cord ischemia/reperfusion injuryen_US
dc.typearticleen_US
dc.relation.journalJournal of Stroke & Cerebrovascular Diseasesen_US
dc.contributor.departmentTıp Fakültesien_US
dc.identifier.volume24en_US
dc.identifier.issue1en_US
dc.identifier.startpage83en_US
dc.identifier.endpage90en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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