• Hipoksi ve kanser 

  Türkoğlu, Sümeyye Aydoğan; Poyrazlı, Fatma; Okuyan, Derya; Köçkar, Feray (Çanakkale Onsekiz Mart Üniversitesi Fen Bilimleri Enstitüsü, 2021)

  Dokudaki gerekli oksijen seviyesinin normal değerin altına düşmesi hipoksi olarak tanımlanır. Hipoksi katı tümörlerde sık karşılaşılan bir durumdur. Tümör hücreleri yeterli oksijen alamadığında hücre ölümüne gitmeden ...

• CA XII expression study in HT 29 colon carcinoma cell line upon cytokine TNF-alpha and TGF-beta stimulations 

  Sağkan, Rahşan İlikçi; Köçkar, Feray; Şengül, Ali (Wiley-Blackwell, 2008)

  Introduction: Carbonic anhydrases (CA, EC 4.2.1.1) are a family of metalloenzymes catalyzing the hydration of CO2 to bicarbonate and a proton. a-Cas is involved in essential cellular functions such as pH regulation, ...

• CA XII expression in HT-29 colon carcinoma cells treated with TNF-alpha and TGF-beta 

  Sağkan, R. İliksi; Köçkar, Feray; Şengül, Ali (Wiley-Blackwell, 2008)

  Introduction: Carbonic anhydrases (CA, EC 4.2.1.1) are a family of metalloenzymes catalyzing the hydration of CO2 to bicarbonate and a proton. a-Cas are involved in essential cellular functions such as pH regulation, ...

• Treatment of the olive beta-glycosidase bound superparamagnetic nanoparticles onto green table olives 

  Karaağaç, Öznur; Savaş, Elif; Kaya, Mihrap Yaşar; Türkoğlu, Sümeyye Aydoğan; Köçkar, Hakan; Köçkar, Feray (Wiley-Blackwell, 2015)

  Treatment of oliveb-glucosidase bound superparamagnetic ironoxide nanoparticles (SPIONs) onto gren table olives were studied.The SPIONs were prepared by co-precipitation Fe+2and Fe+3ions in an ammonia solution at room ...

• Antioxidant properties of Edremit variety green olives (Olea europea L.) 

  Savaş, Elif; Kaya, Mihrap Yaşar; Köçkar, Feray (Wiley-Blackwell, 2015)

  In the past decade, there has been a renewed interest in studyinga wide variety of food sources that show beneficial effects onhuman health. Olea europea L. an important agricultural crop,not only because its economic ...

• Silencing of carbonic anhydrase 9 and tetraspanin-8 caused decrease at invasion capacity of human pancreatic carcinoma (PANC-1) cells 

  Karaman, Musa; Yıldırım, Hatice; Köçkar, Feray (Wiley-Blackwell, 2015)

  Carbonic anhydrases (CAs) (EC 4.2.1.1) are zinc-containing met-alloenzymes that catalyze the hydration of CO2molecule anddehydration of HCO3-ions. Carbonic anhydrase 9 is expressed inmany solid tumors and plays a significant ...

• The cytotoxicity of different pmma/hydroxyapatite nanocomposites 

  Yılmaz, Begümhan; Doğan, Serap (Wiley-Blackwell, 2015)

  Poly(methyl methacrylate) (PMMA) is a polymer that has beenused in dentistry and orthopedic applications for more than 50years. Nanohydroxyapatite is a well known biocompatible parti-cle and it has high compression resistance. ...

• Effects of epidermal growth factor (egf) on caıx and caxıı expression ın mg-63 cells 

  Avcıkurt, Ayla Solmaz; Köçkar, Feray (Wiley-Blackwell, 2015)

  Carbonic anhydrases catalyse the reversible reaction from H2Oand CO2to HCO3-ions. Carbonic Anhydrase IX and CarbonicAnhydrase XII are member of the carbonic anhydrase family.Carbonic Anhydrase IX and Carbonic Anhydrase XII ...

• Inhibition of monoamineoxidase a (Mao-a) by some herbal medicines 

  Güngör, Nuran; Doğan, Serap; Alan, Ümran; Yılmaz, Begümhan (Wiley-Blackwell, 2015)

  In this study, the inhibition effects ofHypericum perforatumL.,Ginkgo bilobaL., Lavandula angustifoliaMiller,Zingiber offici-naleRoscoe,Tilia tomentosaMoench.,Cinnamomum aromaticumJ. Graham, Menthae piperitaL.,Thymus ...

• The determination of effect of some antibiotics on paraoxonase 2 (PON2) enzyme activities in human macrophages cell 

  Avcıkurt, Ayla Solmaz; Köçkar, Feray; Sinan, Selma (Wiley-Blackwell, 2015)

  The human paraoxonase (hPON) gene family includes threemembers: PON1, PON2, and PON3, located adjacent to eachother on the long arm of chromosome 7. The three hPONs shareapproximately 65% identity at the amino acid level ...

• TGF-Beta upregulates URG-4/URGCP gene expression in Hepatoma cells 

  Tokay, Esra; Köçkar, Feray (Wiley-Blackwell, 2015)

  URG-4/URGCP has been found to contribute importantly tomultistep carcinogenesis. Over-expression of URG4/URGCPaccelerated tumor development in nude mice and also induced insome cancer cell types such as hepatocellular ...

• Transcription of the PSMD4 gene is upregulated in hypoxia in prostate cancer cells 

  Türkoğlu, Sümeyye Aydoğan; Güler, Göknur; Köçkar, Feray (Wiley-Blackwell, 2015)

  ThePSMD4(Proteosome 26S non-ATPase subunit 4) gene islocated human chromosome 1. This gene encodes three proteins,namely S5A, antisecretory factor (ASF) and Angiocidin. S5a isthe polyubiquitin binding subunit of the 26S ...

• Transactivation of the human adamts-2 gene promoter through proinflammatory cytokine tnf-alpha in osteoblast-like cells 

  Alper, Murat; Aydemir, Tolunay; Köçkar, Feray (Wiley-blackwell, 2015)

  TNF-ais a proinflammatory cytokine produced by numerous celltypes, including macrophages, lymphocytes, fibroblasts and kerat-inocytes in response to inflammation, infection and other envi-ronmental stresses. TNF-ahas ...

• Genetic mechanism of oleocanthal biosynthesis in olive 

  Koçak, Metin; Dündar, Ekrem; Dağdelen, Ayhan (Wiley-Blackwell, 2016)

  Oleocanthal is an important secondary metabolite that has beenreported to be useful against important human diseases includingcancer. The aim of this study was to identify and characterize thekey biochemical and genetic ...

• Evaluation of the genotoxic potential of some nanocomposites by comet assay 

  Yılmaz, Begümhan; Doğan, Sedat; Kasımoğulları, Serap Çelikler (Wiley-Blackwell, 2016)

  Due to its similar nature to the bone, nanohydroxyapatite is abiocompatible particle and poly(methyl methacrylate) (PMMA)is a polymer that has been used in dentistry and orthopedicapplications for years. In this study, ...

• Bioinformatic analysis and molecular characterization of ethylene-responsive transcription factor RAP2-12 from olive 

  Dizmen, H.; Dündar, Ekrem (Wiley-Blackwell, 2016)

  Ethylene-responsive transcription factorRAP2-12is associatedwith ethylene-response, activation of hypoxic gene and hypoxiatolerance of plants. Under normal aerobic conditions it localizesto the plasma membrane but under ...

• Isolation and characterization of genetic elements related to periodicity and fruit detachment in olive 

  Dündar, Ekrem (Wiley-Blackwell, 2016)

  Periodicity and difficult fruit detachment in olive cause significantyield loss for olive growers. These features greatly differ fromcultivar to cultivar pointing the genetic factors’ roles with theseprocesses. The objective ...

• The effect of sodium perborate tetrahydrate some antioxidant enzyme activities 

  Alan, Ümran; Doğan, Serap; Doğan, Mehmet (Wiley-Blackwell, 2016)

  One of the boron compounds is sodium perborate tetrahydrate(NaBO3.4H2O), which the most widely used solid peroxygencompounds. It is used in safety bleach formulations, detergentsand tooth powders. As known these products ...

• Is thymoquinone promising anticancer agent in hepatoma cell line? 

  Karaman, Musa; Köçkar, İpek Ece; Tokay, Esra; Köçkar, Feray (Wiley-Blackwell, 2016)

  The biological activity ofNigella sativaseeds is mainly attributedto its essential oil component which is pre-dominantly (30–48%)thymoquinone (TQ). Therapeutic effect of TQ was exhibited inmany diseases including inflammation, ...

• Isolation and characterization of an olive splicing factor 3B subunit 1 

  Nurçin, M.; Dündar, Ekrem (Wiley-Blackwell, 2016)

  Splicing factor 3B subunit 1 (SF3B1) functions in the regulationof translation and gene expression. SF3B1 forms U2 smallnuclear ribonucleoprotein complex (U2 snRNP). Splicing factors3A and 3B binds pre-mRNA at the 50site ...

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