CA XII expression in HT-29 colon carcinoma cells treated with TNF-alpha and TGF-beta
Abstract
Introduction: Carbonic anhydrases (CA, EC 4.2.1.1) are a family of
metalloenzymes catalyzing the hydration of CO2 to bicarbonate and a
proton. a-Cas are involved in essential cellular functions such as pH
regulation, respiration, gluconeogenesis, lipogenesis, ureagenesis, tumor
progression. So far, 15 catalytically active carbonic anhydrase isozymes
are described in mammals. hCA XII is one of the transmembrane
human carbonic anhydrase isoforms. hCA XII is present in many normal tissues and overexpressed in some tumors.