CA XII expression study in HT 29 colon carcinoma cell line upon cytokine TNF-alpha and TGF-beta stimulations
Özet
Introduction: Carbonic anhydrases (CA, EC 4.2.1.1) are a family of
metalloenzymes catalyzing the hydration of CO2 to bicarbonate and a
proton. a-Cas is involved in essential cellular functions such as pH regulation, respiration, gluconeogenesis, lipogenesis, ureagenesis, and
tumor progression. So far, 15 catalytically active carbonic anhydrase
isozymes are described in mammals. hCA XII is one of the transmembrane human carbonic anhydrase isoforms. hCA XII is present in
many normal tissues and over-expressed in some tumors
